Nanomedicines: addressing the scientific and regulatory gap.

abstract：:Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type 5 17beta-HSD) reduces Delta(4)-androstene-3,17...

journal_title：Annals of the New York Academy of Sciences

authors： Penning TM,Byrns MC

更新日期：2009-02-01 00:00:00

abstract：:The success of embryonic implantation relies on an ideal cross-talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differen...

journal_title：Annals of the New York Academy of Sciences

authors： Aghajanova L

更新日期：2004-12-01 00:00:00

abstract：:The receptor that mediates the specific uptake and intracellular transport of dimeric immunoglobulin A (IgA dimer) in mucosal and glandular epithelia is identical with a transmembrane precursor of secreted secretory component. During transport, the IgA dimer receptor (membrane SC) is cleaved into two domains, a membra...

journal_title：Annals of the New York Academy of Sciences

authors： Kühn LC,Kraehenbuhl JP

更新日期：1983-06-30 00:00:00

abstract：:Smooth septate junctions (sSJs) are cell-cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ-sp...

journal_title：Annals of the New York Academy of Sciences

authors： Furuse M,Izumi Y

更新日期：2017-06-01 00:00:00

abstract：:In the present article we assessed exposure to polycyclic aromatic hydrocarbons (PAHs) in Italian asphalt workers (AW, n = 100), exposed to bitumen fumes and diesel exhausts, and in roadside construction workers (CW, n = 47), exposed to diesel exhausts, by means of environmental and biological monitoring. 1-hydroxypyr...

journal_title：Annals of the New York Academy of Sciences

authors： Campo L,Buratti M,Fustinoni S,Cirla PE,Martinotti I,Longhi O,Cavallo D,Foà V

更新日期：2006-09-01 00:00:00

abstract：:Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein...

journal_title：Annals of the New York Academy of Sciences

authors： Goodman DS

更新日期：1981-02-27 00:00:00

abstract：:The present paper reviews the major modes of action of estrogen on the molecular, cellular, tissue, and neurobehavioral levels of mammalian physiology, with an emphasis on the brain as an estrogen target tissue. We draw a distinction between receptor- and nonreceptor-mediated actions, as well as delineate the range of...

journal_title：Annals of the New York Academy of Sciences

authors： Scallet AC

更新日期：1999-01-01 00:00:00

abstract：:Three distinct anion exchangers are described that directly or indirectly mediate Cl- transport across the luminal membrane of the proximal tubule cell. Studies on the intact proximal tubule indicate that the Cl(-)-formate exchanger is a major mechanism for Cl- transport under physiologic conditions. As just discussed...

journal_title：Annals of the New York Academy of Sciences

authors： Aronson PS,Kuo SM

更新日期：1989-01-01 00:00:00

abstract：:Prolactin (PL) is a mammotropic neuropeptide produced by the pituitary and extrapituitary cells existing as several isoforms and belongs to the growth and lactogenic hormone family, which includes growth hormone and placental lactogens. The secretion of pituitary PL is under hypothalamic control. The cytokines IL-1, I...

journal_title：Annals of the New York Academy of Sciences

authors： Chikanza IC

更新日期：1999-06-22 00:00:00

abstract：:Mitochondrial dysfunction, due to either environmental or genetic factors, can result in excessive production of reactive oxygen species, triggering the apoptotic death of dopaminergic cells in Parkinson's disease. Mitochondrial free radical production is promoted by the inhibition of electron transport at any point d...

journal_title：Annals of the New York Academy of Sciences

authors： Fiskum G,Starkov A,Polster BM,Chinopoulos C

更新日期：2003-06-01 00:00:00

abstract：:Growing evidence from clinical and epidemiological studies points to a synchronized increase in the incidence of male reproductive problems, such as genital abnormalities, testicular cancer, reduced semen quality, and subfertility. Together these male reproductive problems may reflect the existence of one common entit...

journal_title：Annals of the New York Academy of Sciences

authors： Boisen KA,Main KM,Rajpert-De Meyts E,Skakkebaek NE

更新日期：2001-12-01 00:00:00

abstract：:To study the role of the LDL receptor pathway for the maintenance of alpha-tocopherol concentrations in tissues of intact animals, we have compared vitamin E levels in plasma and tissues of normal rabbits and WHHL rabbits. WHHL rabbits are deficient in LDL receptor activity. For WHHL rabbits, alpha-tocopherol plasma c...

journal_title：Annals of the New York Academy of Sciences

authors： Cohn W,Kuhn H

更新日期：1989-01-01 00:00:00

abstract：:The present study was aimed at finding neural correlates of aesthetic versus descriptive listening of the same musical cadences. Results showed that aesthetic listening generated greater right frontocentral negativities than did descriptive listening, indicating distinct cortical mechanisms for aesthetic versus descri...

journal_title：Annals of the New York Academy of Sciences

authors： Brattico E,Jacobsen T,De Baene W,Nakai N,Tervaniemi M

更新日期：2003-11-01 00:00:00

abstract：:The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

journal_title：Annals of the New York Academy of Sciences

authors： Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

更新日期：2005-12-01 00:00:00

abstract：:The song system of oscine birds has become a versatile model system that is used to study diverse problems in neurobiology. Because the song system is often studied with the intention of applying the results to mammalian systems, it is important to place song system brain nuclei in a broader context and to understand ...

journal_title：Annals of the New York Academy of Sciences

authors： Farries MA

更新日期：2004-06-01 00:00:00

abstract：:Alcohol suppresses reproduction in humans, monkeys, and small rodents by suppressing release of luteinizing hormone (LH). The major action is on the hypothalamus to decrease release of LH-releasing hormone (LHRH). The release of LHRH is controlled by nitric oxide (NO) as determined by in vivo and in vitro experiments....

journal_title：Annals of the New York Academy of Sciences

authors： Rettori V,McCann SM

更新日期：1998-05-01 00:00:00

abstract：:The extreme toxicity of organophosphorous-based compounds has been known since the late 1930s. Starting in the mid-1940s, many nations throughout the world have been producing large quantities of organophosphorous (OP) nerve agents. Huge stockpiles of nerve agents have since developed. There are reportedly more than 2...

journal_title：Annals of the New York Academy of Sciences

authors： LeJeune KE,Dravis BC,Yang F,Hetro AD,Doctor BP,Russell AJ

更新日期：1998-12-13 00:00:00

abstract：:Significant advances have recently been made in understanding the regulation of Ca(2+)-ATPase by phospholamban and in modeling their structures. However, these insights would be furthered by determining the 3-D structure of both proteins within the membrane, thus revealing the structural basis for their interaction. T...

journal_title：Annals of the New York Academy of Sciences

authors： Young HS,Reddy LG,Jones LR,Stokes DL

更新日期：1998-09-16 00:00:00

abstract：:To understand the molecular mechanism of endometrial differentiation we have initiated an analysis of the uteroglobin promoter. Uteroglobin is normally expressed in endometrial tissues under the control of ovarian hormones. In gene transfer experiments with the Ishikawa cell line, derived from a human endometrial aden...

journal_title：Annals of the New York Academy of Sciences

authors： Helftenbein G,Misseyanni A,Hagen G,Peter W,Slater EP,Wiehle RD,Suske G,Beato M

更新日期：1991-01-01 00:00:00

abstract：:We review here evidence that a large portion of the caudomedial telencephalon of songbirds, distinct from the song control circuit, is involved in the perceptual processing of birdsong. When songbirds hear song, a number of caudomedial pallial areas are activated, as revealed by expression of the activity-dependent ge...

journal_title：Annals of the New York Academy of Sciences

authors： Mello CV,Velho TA,Pinaud R

更新日期：2004-06-01 00:00:00

abstract：:Recent advances in the development of three different types of antiviral drugs, the nucleotide and non-nucleotide analogues acting as reverse transcriptase inhibitors (NRTIs) and the nonpeptidic viral protease inhibitors (PI), and their introduction in the management of patients with AIDS, either alone or in combinati...

journal_title：Annals of the New York Academy of Sciences

authors： Kino T,Chrousos GP

更新日期：2004-06-01 00:00:00

abstract：:Today, we see a growing concern for the quality of life of nonhuman animals and an accompanying call for viable means of assessing how well animals thrive. Past research focused on minimizing negatives such as stress, while more recent endeavors strive to promote positives such as happiness. But what is animal happine...

journal_title：Annals of the New York Academy of Sciences

authors： Webb LE,Veenhoven R,Harfeld JL,Jensen MB

更新日期：2019-02-01 00:00:00

abstract：:Despite a globally uniform increase in the concentrations of emitted greenhouse gases, radiatively forced surface warming can have significant spatial variations. These define warming patterns that depend on preexisting climate states and through atmospheric and oceanic dynamics can drive changes of the hydrological c...

journal_title：Annals of the New York Academy of Sciences

authors： Ma J,Zhou L,Foltz GR,Qu X,Ying J,Tokinaga H,Mechoso CR,Li J,Gu X

更新日期：2020-07-01 00:00:00

abstract：:It is well known that hemodynamic load is one of the most important determinants of cardiac structure and function. Circadian variations in blood pressure (BP) values are usually accompanied by consensual changes in peripheral resistance and/or cardiac output. In recent years, in hypertensive patients with left ventri...

journal_title：Annals of the New York Academy of Sciences

authors： Rizzoni D,Agabiti-Rosei E

更新日期：1996-08-15 00:00:00

abstract：:[(18) F]Fluorodeoxyglucose (FDG) is a tracer for glucose metabolism. Its distribution is not specific to cancer cells but is also observed in inflammatory tissue, including macrophages, capillaries, and fibroblasts. Rheumatoid arthritis (RA) is a systemic, chronic inflammation of the joints resulting in synovitis. The...

journal_title：Annals of the New York Academy of Sciences

authors： Kubota K,Ito K,Morooka M,Minamimoto R,Miyata Y,Yamashita H,Takahashi Y,Mimori A

更新日期：2011-06-01 00:00:00

abstract：:Autoimmune diseases include a diverse group of over 80 conditions. Sjögren's syndrome is the second most common autoimmune rheumatic disease, with an estimated prevalence in the United States of 2-4 million persons. There are prominent and consistent oral and dental findings in Sjögren's syndrome related to the autoim...

journal_title：Annals of the New York Academy of Sciences

authors： Fox PC

更新日期：2007-03-01 00:00:00

abstract：:Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organi...

journal_title：Annals of the New York Academy of Sciences

authors： Hertzman C

更新日期：1999-01-01 00:00:00

abstract：:The DNase activity and circulating DNA (cirDNA) concentration in blood plasma of healthy donors, patients with chronic prostatitis, and patients with prostate tumors were analyzed. The concentration of the cirDNA from plasma was determined by PicoGreen fluorescent assay. DNase activity in blood was measured using the ...

journal_title：Annals of the New York Academy of Sciences

authors： Cherepanova AV,Tamkovich SN,Bryzgunova OE,Vlassov VV,Laktionov PP

更新日期：2008-08-01 00:00:00

abstract：:The strategy of "manufacturing uncertainty" has been used with great success by polluters and manufacturers of dangerous products to oppose public health and environmental regulation. This strategy entails questioning the validity of scientific evidence on which the regulation is based. While this approach is most ide...

journal_title：Annals of the New York Academy of Sciences

authors： Michaels D

更新日期：2006-09-01 00:00:00

abstract：:Currently up to one-third of colorectal cancer patients present with locally advanced or metastatic disease that precludes a surgical cure. Performance limitations and low uptake of current screening tools have fueled research to develop minimally invasive approaches that can detect early-stage neoplasms. The observat...

journal_title：Annals of the New York Academy of Sciences

authors： Jubb AM,Quirke P,Oates AJ

更新日期：2003-03-01 00:00:00