Are male reproductive disorders a common entity? The testicular dysgenesis syndrome.

Abstract:

:Growing evidence from clinical and epidemiological studies points to a synchronized increase in the incidence of male reproductive problems, such as genital abnormalities, testicular cancer, reduced semen quality, and subfertility. Together these male reproductive problems may reflect the existence of one common entity, a testicular dysgenesis syndrome (TDS). Experimental and epidemiological studies suggest that TDS is a result of disruption of embryonal programming and gonadal development during fetal life. The recent rise in the prevalence of TDS may be causally linked to endocrine disrupters affecting genetically susceptible individuals. We recommend that future epidemiological studies on trends in male reproduction do not focus on one symptom only, but take all aspects of TDS into account. The potential impact of adverse environmental factors and the role of genetic polymorphisms involved in gonadal development requires further research.

journal_name

Ann N Y Acad Sci

authors

Boisen KA,Main KM,Rajpert-De Meyts E,Skakkebaek NE

doi

10.1111/j.1749-6632.2001.tb03990.x

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

90-9

eissn

0077-8923

issn

1749-6632

journal_volume

948

pub_type

杂志文章,评审
  • ACE inhibitor captopril reduces ecdysteroids and oviposition in moths.

    abstract::By using the selective ACE inhibitor captopril, we studied the effect of the angiotensin converting enzyme (ACE) on larval growth, metamorphosis, and reproduction in a lepidopteran species, the cotton leafworm, Spodoptera littoralis. Captopril was detrimental to adult formation and oviposition, and in female moths it ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1327.102

    authors: Vercruysse L,Gelman D,van de Velde S,Raes E,Hooghe B,Vermeirssen V,van Camp J,Smagghe G

    更新日期:2005-04-01 00:00:00

  • Therapeutic approaches to pulmonary hypertension in hemoglobinopathies: Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathy.

    abstract::New approaches to the treatment of pulmonary arterial hypertension (PH) have increased symptomatic relief and prolonged survival. PH is a common sequela of the hemoglobinopathies, but the use of standard oral treatment options is limited because of toxicity and poor effectiveness. Sildenafil citrate is a selective and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1345.070

    authors: Derchi G,Forni GL

    更新日期:2005-01-01 00:00:00

  • Human granulocytic ehrlichiosis in Italy: first report on two confirmed cases.

    abstract::We report here the two first cases of human ehrlichiosis described in Italy. One patient presented symptoms indicative of ehrlichiosis, such as fever, conjunctivitis, and increase of hepatic enzymes; HGE was confirmed by fourfold seroconversion for HGE antigen. The second patient, a forest worker, was affected by Lyme...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07387.x

    authors: Ruscio M,Cinco M

    更新日期:2003-06-01 00:00:00

  • The role of auditory feedback in birdsong.

    abstract::Young songbirds memorize a tutor song and use the memory trace as a template to shape their own song by auditory feedback. Major issues in birdsong research include the neural sites and mechanisms for song memory and auditory feedback. The brain song control system contains neurons with both premotor and auditory func...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1298.010

    authors: Konishi M

    更新日期:2004-06-01 00:00:00

  • Ethnoveterinary medicine and indigenous pharmacopoeia of Passoré Province in Burkina Faso.

    abstract::A study of traditional animal health care practices in Passoré province of Burkina Faso led to the characterization of 24 diseases, together with their local names, causes of their appearance, and their treatment. Most (95%) of the medicinal recipes used to treat affected animals were based on plants. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05298.x

    authors: Tamboura HH,Sawadogo LL,Kaboré H,Yameogo SM

    更新日期:2000-01-01 00:00:00

  • The Irie Classroom Toolbox: developing a violence prevention, preschool teacher training program using evidence, theory, and practice.

    abstract::In this paper, I describe the development of the Irie Classroom Toolbox, a school-based violence prevention, teacher training program for use with children aged 3-6 years. In-depth interviews were conducted with Jamaican preschool teachers, who had participated in a trial of a classroom behavior management program, at...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13713

    authors: Baker-Henningham H

    更新日期:2018-05-01 00:00:00

  • Audiovisual interactions in music reading. A reaction times and event-related potentials study.

    abstract::The general aim of this experiment was to investigate the processes involved in reading musical notation and to study the relationship between written music and its auditory representation. Our main interest was to determine if musicians can develop expectancies for plausible or implausible auditory events on the sole...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1284.028

    authors: Schön D,Besson M

    更新日期:2003-11-01 00:00:00

  • Peptides and the blood-brain barrier: the status of our understanding.

    abstract::In this limited review, it has only been possible to highlight some of the more significant interactions of peptides with the blood-brain barrier. The literature has been reviewed extensively in recent years, and the major reviews are included in the references. Certainly one of the major outstanding problems is an el...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb19810.x

    authors: Begley DJ

    更新日期:1994-10-31 00:00:00

  • Co-reconstitution and co-crystallization of phospholamban and Ca(2+)-ATPase.

    abstract::Significant advances have recently been made in understanding the regulation of Ca(2+)-ATPase by phospholamban and in modeling their structures. However, these insights would be furthered by determining the 3-D structure of both proteins within the membrane, thus revealing the structural basis for their interaction. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb08260.x

    authors: Young HS,Reddy LG,Jones LR,Stokes DL

    更新日期:1998-09-16 00:00:00

  • Perceiving others' perceptions of risk: still a task for Sisyphus.

    abstract::The recent literature providing insights from neuroscience and evolutionary biology into how individuals perceive risky choice situations represents a "second wave" of findings that recapitulates as well as challenges the risk perception research begun in the 1980s, which relied on psychometric survey research. Gleani...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1399.013

    authors: Finkel AM

    更新日期:2008-04-01 00:00:00

  • Transformation of a methylotrophic bacterium, Methylobacterium extorquens, with a broad-host-range plasmid by electroporation.

    abstract::Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb18568.x

    authors: Ueda S,Matsumoto S,Shimizu S,Yamane T

    更新日期:1991-12-27 00:00:00

  • Clinical and experimental studies on adenine, various nucleosides and their analogs in hematology.

    abstract::In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1975.tb29250.x

    authors: Ambrus JL,Ambrus CM,Odake K,Mink IB,Shields R,Warner W,Bishop C,Tritsch GL,Golden G,Mittelman A

    更新日期:1975-08-08 00:00:00

  • Two NIOSH resources for implementing workplace safety and health surveillance.

    abstract::To improve safety and health in the workplace, appropriate occupational health programs should be implemented utilizing expertise from multiple disciplines. In other words, the occupational health program should be a team effort. Expertise from all aspects of occupational health should be utilized, from the industrial...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb56884.x

    authors: Murthy LI

    更新日期:1997-12-26 00:00:00

  • Validation of a Rickettsia prowazekii-specific quantitative real-time PCR cassette and DNA extraction protocols using experimentally infected lice.

    abstract::The presence of R. prowazekii in lice using R. prowazekii-specific qPCR cassettes showed the changes of the rickettsial burden in the lice post-infection. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1374.036

    authors: Rozmajzl PJ,Houhamdi L,Jiang J,Raoult D,Richards AL

    更新日期:2006-10-01 00:00:00

  • Old acetogens, new light.

    abstract::Acetogens utilize the acetyl-CoA Wood-Ljungdahl pathway as a terminal electron-accepting, energy-conserving, CO(2)-fixing process. The decades of research to resolve the enzymology of this pathway (1) preceded studies demonstrating that acetogens not only harbor a novel CO(2)-fixing pathway, but are also ecologically ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1419.016

    authors: Drake HL,Gössner AS,Daniel SL

    更新日期:2008-03-01 00:00:00

  • Enhancing the sensitivity of assays to detect T cell reactivity: the effect of cell separation and cryopreservation media.

    abstract::The identification of sensitive assay formats capable of distinguishing islet autoreactive T cells directly ex vivo in blood is a major goal in type 1 diabetes research. Whereas much effort has been made to identify suitable assay formats, relatively little attention has been paid to optimizing the quality of cell pre...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1337.005

    authors: Tree TI,Roep BO,Peakman M

    更新日期:2004-12-01 00:00:00

  • Perceiving prosody in speech. Effects of music lessons.

    abstract::In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1284.067

    authors: Thompson WF,Schellenberg EG,Husain G

    更新日期:2003-11-01 00:00:00

  • Humanized mice for the study of type 1 and type 2 diabetes.

    abstract::The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06318.x

    authors: Greiner DL,Brehm MA,Hosur V,Harlan DM,Powers AC,Shultz LD

    更新日期:2011-12-01 00:00:00

  • Alcohol and drug abusers subtyped by antisocial personality and primary or secondary depressive disorder.

    abstract::Our data show that when substance abusers are subtyped simultaneously by antisocial personality disorder and the onset of depression relative to alcohol or drug abuse, groups of people with unique personality and affective profiles are identified. The profiles are represented by measures of affect-related personality ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb24712.x

    authors: Epstein EE,Ginsburg BE,Hesselbrock VM,Schwarz JC

    更新日期:1994-02-28 00:00:00

  • Factors affecting tracking of coronary heart disease risk factors in children. The Muscatine Study.

    abstract::The public health implications of reducing or preventing the excess increase in blood pressure and the acquisition of obesity during childhood years are important. Many children with high blood pressure, particularly those who are initially obese or become obese as young adults and those with excess left ventricular m...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb43723.x

    authors: Mahoney LT,Lauer RM,Lee J,Clarke WR

    更新日期:1991-01-01 00:00:00

  • In vitro formation of macrophage-epithelioid cells and multinucleated giant cells by 1 alpha,25-dihydroxyvitamin D3 from human circulating monocytes.

    abstract::1 alpha,25-Dihydroxyvitamin D3, the active form of vitamin D3, induced maturation of circulating monocytes to form macrophage-epithelioid cells and multinucleated giant cells in vitro. Calcitriol not only promoted the differentiation of monocytes, as shown by the marked morphological changes and enhanced secretion of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb18497.x

    authors: Ohta M,Okabe T,Ozawa K,Urabe A,Takaku F

    更新日期:1986-01-01 00:00:00

  • Protein oxidation.

    abstract::The oxidative modification of proteins by reactive species, especially reactive oxygen species, is implicated in the etiology or progression of a panoply of disorders and diseases. These reactive species form through a large number of physiological and non-physiological reactions. An increase in the rate of their prod...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06187.x

    authors: Stadtman ER,Levine RL

    更新日期:2000-01-01 00:00:00

  • Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?

    abstract::Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and we...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1196/annals.1314.040

    authors: Joffe RT,Sawka AM,Marriott MJ,MacQueen GM,Gernstein HC

    更新日期:2004-12-01 00:00:00

  • Modeling the mechanisms of Uhthoff's phenomenon in MS patients with internuclear ophthalmoparesis.

    abstract::Internuclear ophthalmoparesis (INO) is the most common saccadic eye movement disorder observed in patients with multiple sclerosis (MS). It is characterized by slowing of the adducting eye during horizontal saccades, and most commonly results from a demyelinating lesion in the medial longitudinal fasciculus (MLF) with...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06125.x

    authors: Frohman TC,Davis SL,Frohman EM

    更新日期:2011-09-01 00:00:00

  • Neuronal signals for reward risk in frontal cortex.

    abstract::Rewards can be viewed as probability distributions of reward values. Besides expected (mean) value, a key parameter of such distributions is variance (or standard deviation), which constitutes a measure of risk. Single neurons in orbitofrontal cortex signal risk mostly separately from value. Comparable risk signals in...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06256.x

    authors: Schultz W,O'Neill M,Tobler PN,Kobayashi S

    更新日期:2011-12-01 00:00:00

  • New in vitro findings on the "free" form of apolipoprotein A-1.

    abstract::Clinical and experimental gerontologists are extremely interested in lipoproteins as well as in new methods for investigating and probing the apolipoprotein pattern. Using immunofixation electrophoresis, we separated free apolipoprotein A-1 from the apo A-1 associated with high-density lipoproteins. Free apolipoprotei...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb27469.x

    authors: Giunta S,Maddalena-Peruzzi A,Gaudio MR,Semprini A

    更新日期:1992-12-26 00:00:00

  • Mitochondrial DNA variation in the aboriginal populations of the Altai-Baikal region: implications for the genetic history of North Asia and America.

    abstract::The discovery of mtDNA types common to Asians and Amerinds (types A, B, C, and D) forced investigators to search for those nations of Asia which, though not considered the ancestors of the Amerinds, have retained a close genetic resemblance with them. We collected samples and studied the gene pools of the Turkic-speak...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1007/978-3-662-41088-2_3

    authors: Zakharov IA,Derenko MV,Maliarchuk BA,Dambueva IK,Dorzhu CM,Rychkov SY

    更新日期:2004-04-01 00:00:00

  • Regulation of the expression of class II genes of the human major histocompatibility complex in tumor cells.

    abstract::The control of expression of human class II MHC genes has been studied in lymphoid and melanoma cells. Specific unmethylation of all restriction sites nearby the promoter regions has been detected in all cell lines and tissues studied, irrespective of their ability to express class II MHC products. The main functional...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb36258.x

    authors: Gambari R,Barbieri R,Piva R,Tecce R,Fisher PB,Giacomini P,Natali PG

    更新日期:1987-01-01 00:00:00

  • Thymic abnormalities: antigen or antibody? Response to thymectomy in myasthenia gravis.

    abstract::The therapeutic value of thymectomy for myasthenia is still questioned although it retains an important place among management modalities that strive for sustained remission. Questions derive from uncertainty as to appropriate timing, variable extent of resection and quantitation of response. Forty-seven patients, fol...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1981.tb33776.x

    authors: Penn AS,Jaretzki A 3rd,Wolff M,Chang HW,Tennyson V

    更新日期:1981-01-01 00:00:00

  • Epilepsy in the elderly.

    abstract::The elderly, often defined as those 65 years or older, are the most rapidly growing segment of the population, and onset of epilepsy is higher in this age group than in any other. This paper reviews recent developments, including a new proposed definition of epilepsy, a transgenic mouse model of Alzheimer's disease th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05113.x

    authors: Leppik IE,Birnbaum AK

    更新日期:2010-01-01 00:00:00