Abstract:
BACKGROUND AND PURPOSE:Data on safety of intravenous thrombolysis with recombinant tissue-type plasminogen activator for acute ischemic stroke in patients with coexisting cerebral cavernous malformations (CCMs) are scarce. We assessed the risk of thrombolysis-associated hemorrhage in these patients. METHODS:We searched our tertiary care hospital thrombolysis register for patients with CCM confirmed by MRI (3 T, Siemens, TimTrio) before thrombolysis for acute ischemic stroke. CCMs were graded into subtypes according to the Zabramski classification on the basis of their MRI appearance. The primary end point was symptomatic intracerebral hemorrhage according to European Cooperative Acute Stroke Study III (ECASS III) criteria. The secondary end point was any parenchymal hemorrhage. RESULTS:In a total of 350 patients (median age, 76 years; interquartile range, 68-84; median National Institutes of Health Stroke Scale score, 8; interquartile range, 5-14; 51.4% women), CCMs were found in 9 patients (2.6%). Seven patients had a single CCM, and 2 patients had multiple CCMs with a total number of 12 CCMs in all patients. The subtype of CCMs was type III in 9 cases and type I in 3 cases. Symptomatic intracerebral hemorrhage occurred in 1 of 9 patients with CCM versus 11 of 341 patients without CCM (P=0.27). Parenchymal hemorrhage occurred in 2 of 9 patients with CCM versus 27 of 341 patients (P=0.17) without CCM. CONCLUSIONS:Given the limitations of our study (mainly low number of patients with CCM), the risk of thrombolysis-associated hemorrhage in patients with CCM remains uncertain. Although our data do not suggest an increased hazard from thrombolysis in patients with CCM, larger studies are necessary to determine definitively the influence of CCMs on parenchymal hemorrhage and symptomatic intracerebral hemorrhage.
journal_name
Strokejournal_title
Strokeauthors
Erdur H,Scheitz JF,Tütüncü S,Fiebach JB,Endres M,Werring DJ,Nolte CHdoi
10.1161/STROKEAHA.113.004559subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1846-8issue
6eissn
0039-2499issn
1524-4628pii
STROKEAHA.113.004559journal_volume
45pub_type
杂志文章,多中心研究相关文献
STROKE文献大全abstract:BACKGROUND:Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures. Neurological symptoms are variable, and the clinical diagnosis is difficult. The purpose of this case study is to demonstrate the value of diffusion-weighted MRI of the brain for early diagnosis of fat embo...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported on the correlation of ultrasonic carotid plaque morphology, cerebrovascular symptoms, and intraplaque hemorrhage. This study correlates ultrasonic carotid plaque morphology with the degree of carotid stenosis. METHODS:Carotid arteries (n=2460) were examined by using...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000019127.11189.b5
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to assess the geographic proximity of patients with stroke in California to centers that performed specific threshold volumes of mechanical embolectomy procedures each year. METHODS:We identified all patients who were hospitalized for acute ischemic stroke at all nonfederal acute care ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007735
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of the present study was to evaluate the impact of basilar artery (BA) vasospasm on outcome in patients with severe vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). METHODS:Sixty-five patients with clinically suspect severe cerebral vasospasm after aSAH underwent cerebral a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000244765.29502.85
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence of a relationship of fish intake to stroke incidence or mortality is weak. This report examines the association of fish consumption with stroke. METHODS:A cohort of 2107 men aged 40 to 55 years from the Chicago Western Electric Study who were free of coronary heart disease and stroke th...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.2.204
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recovery of upper-limb motor impairment after first-ever ischemic stroke is proportional to the degree of initial impairment in patients with a functional corticospinal tract (CST). This study aimed to investigate whether proportional recovery occurs in a more clinically relevant sample including...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.016020
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cells lacking the ATM (ataxia telangectasia mutated) gene are hypersensitive to DNA damage caused by a variety of insults. ATM may regulate oxidative stress-induced signaling cascades involving nuclear factor-kappaB (NF-kappaB), a transcription factor that is upstream of a wide variety of stress-...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000030316.79601.03
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.117.019896
更新日期:2018-03-01 00:00:00
abstract::Background and Purpose- In this era of endovascular therapy (EVT) with early, complete recanalization and reperfusion, we have observed an even more rapid apparent diffusion coefficient (ADC) normalization within the acute ischemic lesion compared with the natural history or IV-tPA-treated patient. In this study, we a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.025784
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.112.667535
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To test the role of fibrinolysis in stroke, we used a mouse model in which preformed 2.5- to 3-microm-diameter fibrin microemboli are injected into the cerebral circulation. The microemboli lodge in the downstream precapillary vasculature and are susceptible to fibrinolysis. METHODS:We injected ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000137412.35700.0e
更新日期:2004-09-01 00:00:00
abstract::The purpose of this work was to study the contractile activity of intracerebral microarterioles and their sensitivity to the calcium antagonist nimodipine. Potassium depolarization evoked contraction and rhythmic activity that was blocked by nimodipine (IC50 0.08 nM). High concentrations of noradrenaline and prostagla...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The initial thrombus was present only in the right channel of a congenitally bifurcated superior sagittal sinus. This diagnosis and subsequent thrombus extension were readily shown by magnetic resonance imaging in contrast...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.3.396
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study investigated the influence of the antiplatelet agent acetylsalicylic acid (ASA) on cerebral microembolism as detected by transcranial Doppler sonography (TCD). METHODS:Nine patients with recent transient ischemic attack or minor stroke of arterial origin were investigated. Eigh...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.30.1.66
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear. METHODS:This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of as...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.113.004251
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite rapid advancements in intracranial aneurysm management, there is no evidence as of yet that this has translated into improvement in overall prognosis. METHODS:We compared 2 periods of aneurysm management, 1998 to 2003 (n=1023 aneurysms) and 2007 to 2013 (n=1499 aneurysms), at a single, h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.011959
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Rates of development of de novo intracranial aneurysms and of growth of untreated additional aneurysms are largely unknown. We performed MRA in a large patient cohort with coiled aneurysms at 5-year follow-up. METHODS:In 276 patients with coiled intracranial aneurysms and 5±0.5 years of follow-u...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,评审
doi:10.1161/STROKEAHA.110.591594
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion evolution. N-Methyl-D-aspartate (NMDA) antagonists inhibit SDs and reduce infarct size. The glycine site on the NMDA receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.1.190
更新日期:1998-01-01 00:00:00
abstract::Background and Purpose- Delirium is a common and serious complication of acute illness. We describe delirium occurrence in an unselected, acute stroke population. Methods- We collected data from consecutive stroke admissions. We performed comprehensive cognitive assessment within the first week including Diagnostic St...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.119.025993
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.111.645499
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The influence of a nocturnal blood pressure dip on stroke recurrence has not yet been clarified. In this pilot study, we attempted to establish a correlation of the nocturnal blood pressure dip with stroke recurrence and development of new silent ischemic lesions in patients with chronic ischemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.8.1373
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with arteriovenous malformations are younger individuals who are at risk of a stroke or have experienced one. Our objective was to determine these patients' perceptions of quality of life with a stroke by eliciting utility values. METHODS:Utility values were obtained with the standard g...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.28.12.2395
更新日期:1997-12-01 00:00:00
abstract::Background and Purpose- Although older age is one of the most important risk factor for stroke in atrial fibrillation (AF), the appropriate age threshold (eg, CHA2DS2-VASc score [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vas...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021047
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset. METHODS:Ischemic lesion volumes were measured for intrarater reliability using diffusion-weighted (DWI), mean transit time (MTT) perfusio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000249416.77132.1a
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid plaque composition is a major determinant of cerebrovascular events. In the present analysis, we evaluated the relationship between intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (TRFC) in moderately stenosed carotid arteries and cerebral infarcts on MRI in the ipsilateral h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.008121
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Mild stroke (MS) and rapidly improving stroke (RIS) symptoms are common stroke presentations. Our objective is to describe the short-term outcomes in this population. METHODS:A retrospective analysis of patients with ischemic stroke in the Get With The Guidelines-Stroke registry who arrived ≤4.5...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.011528
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hypothermia to core temperatures ranging from 16 degrees C to 24 degrees C has become an established procedure to extend the "safe" interval of cardiac arrest during open heart surgery in human infants. The present experiment was designed to ascertain whether differences in core (rectal) temperat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.7.1433
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk factors remain poorly defined. Coagulation factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs1101.098150
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.670463
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Perivascularly positioned cerebral mast cells (MC) have been shown to participate in acute blood-brain barrier disruption and expansive brain edema following experimental transient cerebral ischemia. However, the underlying molecular mechanisms remain unknown. Because proteolytic gelatinase enzym...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.632224
更新日期:2011-12-01 00:00:00