Abstract：
OBJECTIVE:To compare ondansetron with metoclopramide in the treatment of hyperemesis gravidarum. METHODS:We enrolled 160 women with hyperemesis gravidarum in a double-blind randomized trial. Participants were randomized to intravenous 4 mg ondansetron or 10 mg metoclopramide every 8 hours for 24 hours. Participants kept an emesis diary for 24 hours; at 24 hours, they expressed their well-being using a 10-point visual numeric rating scale and answered an adverse effects questionnaire. Nausea intensity was evaluated using a 10-point visual numeric rating scale at enrollment and at 8, 16, and 24 hours. Primary analysis was on an intention-to-treat basis. RESULTS:Eighty women each were randomized to ondansetron or metoclopramide. Median well-being visual numeric rating scale scores were 9 (range, 5-10) compared with 9 (range, 4-10) (P=.33) and vomiting episodes in the first 24 hours were 1 (range, 0-9) compared with 2 (range, 0-23) (P=.38) for ondansetron compared with metoclopramide, respectively. Repeat-measures analysis of variance of nausea visual numeric rating scale showed no difference between study drugs (P=.22). Reported rates of drowsiness (12.5% compared with 30%; P=.01; number needed to treat to benefit, 6), xerostomia (10.0% compared with 23.8%; P<.01; number needed to treat to benefit, 8), and persistent ketonuria at 24 hours (12.5% compared with 30%; P=.01; number needed to treat to benefit, 6) were less frequent with ondansetron. Length of hospital stay was similar. CONCLUSION:Ondansetron and metoclopramide demonstrated similar antiemetic and antinauseant effects in hyperemesis gravidarum. However, the overall profile, particularly regarding adverse effects, was better with ondansetron. In our setting, metoclopramide was significantly less expensive than ondansetron and remained a reasonable antiemetic choice. CLINICAL TRIAL REGISTRATION:ISRCN Register, www.isrctn.org, ISRCTN00592566. LEVEL OF EVIDENCE:I.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Abas MN,Tan PC,Azmi N,Omar SZdoi
10.1097/AOG.0000000000000242subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1272-1279issue
6eissn
0029-7844issn
1873-233Xpii
00006250-201406000-00018journal_volume
123pub_type
杂志文章,随机对照试验abstract：OBJECTIVE:To assess the antecedents of shoulder dystocia, the risk of recurrence, and the perinatal morbidity associated with the different maneuvers used for its management. METHODS:We conducted a 10-year (1980-1989) retrospective case record review of all instances of shoulder dystocia in a teaching maternity hospit...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(95)00099-D
更新日期：1995-07-01 00:00:00
abstract：:Understanding the importance of circumcision in the religious history of Western civilization provides an insight into why the surgical procedure is still so prevalent today. Circumcision appears as a motif in the religious literature of Western civilization throughout the ages. The history of the Jewish faith can be ...
journal_title：Obstetrics and gynecology
pub_type： 历史文章,杂志文章
doi：10.1097/00006250-197804000-00023
更新日期：1978-04-01 00:00:00
abstract：BACKGROUND:Retained viable intrauterine pregnancy is an infrequent complication of vacuum aspiration. We report a case of a retained single intrauterine pregnancy after an elective vacuum aspiration of a dichorionic-diamniotic twin gestation. CASE:A patient presented to the emergency department reporting vaginal spott...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181dd1fac
更新日期：2010-08-01 00:00:00
abstract：:Preterm birth occurs in approximately 10% of all births in the United States and is a major contributor to perinatal morbidity and mortality (). Prelabor rupture of membranes (PROM) that occurs preterm complicates approximately 2-3% of all pregnancies in the United States, representing a significant proportion of pret...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,实务指引
doi：10.1097/AOG.0000000000003700
更新日期：2020-03-01 00:00:00
abstract：:Ten cases of malignant tumors arising in foci of gonadal and extragonadal endometriosis are reported and added to 195 previously reported cases from the English literature. The ovary was the primary site in 165 (78.7%) of the cases, whereas extragonadal sites represented 44 (21.3%). Endometrioid adenocarcinomas accoun...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVE:To determine the serum level of macrophage colony-stimulating factor in ovarian cancer patients in order to evaluate its role as a marker for ovarian cancer. METHODS:Serum macrophage colony-stimulating factor levels were assayed in 69 patients with epithelial ovarian cancer, 55 with benign ovarian tumors, an...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Ectopic pregnancy is suspected when a pregnancy test is positive and an Arias-Stella phenomenon with decidua is seen on endometrial curettings in the absence of chorionic villi and trophoblast. We performed immunoperoxidase stains for beta-hCG, hPL, placental alkaline phosphatase, and keratin (AE1/AE3) on endometrial ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:Erythrasma is an uncommon vulvar infection, best diagnosed by its fluorescence under the Wood lamp. This report shows that despite a negative Wood lamp examination, the diagnosis can be made histologically. CASE:A 42-year-old woman was referred to our clinic with a persistent candidal infection. Evaluation ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:A study of the effect of posture on plasma renin activity (PRA) in the third trimester in 27 gravidas revealed a significantly greater increase in PRA in the supine position, compared to the left lateral. The women were classified into 3 groups: normal pregnancy, preeclampsia, intrauterine fetal death. There was no st...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the use of the Auto Suture Poly CS-57 disposable surgical stapler to determine if the device offers any advantages over suture closure of the uterus. METHODS:A matched case-control study design was used. Operative time, estimated blood loss, change in hematocrit, incidence of postoperative endome...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(95)00438-6
更新日期：1996-03-01 00:00:00
abstract：:Fetal oxytocin contribution to the mother during spontaneous labor was investigated using a specific and sensitive radioimmunoassay to measure oxytocin in blood, amniotic fluid, and urine. In 26 subjects with spontaneous labor and vaginal delivery (Group I) and 18 subjects with cesarean section after labor (Group II),...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：OBJECTIVE:To determine the association between pretreatment platelet count and survival in women with stage IB cervical cancer. METHODS:Clinical records were reviewed for 219 women with stage IB cervical cancer treated by radical hysterectomy from 1971-1984. Univariate and multivariate analyses were performed to ident...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Findings on ultrasound scanning of the cervix and lower uterine segment were compared with those on digital examination in patients in preterm labor or those in whom induction was planned. An ultrasound scoring system gave results that corresponded closely to those of the Bishop score. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：OBJECTIVE:To assess whether lack of patient preparation for common physical and emotional postpartum symptoms is associated with patient satisfaction with obstetric clinicians. METHODS:We conducted a telephone survey of 724 postpartum women. Women were interviewed 2 weeks postpartum to assess self-perceived preparatio...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181c8b39b
更新日期：2010-02-01 00:00:00
abstract：:Three patients with International Federation of Gynecology and Obstetrics state IIIC ovarian adenocarcinoma underwent CO2 laser vaporization of large-volume (5-6 cm) and miliary right hemidiaphragmatic metastases at the conclusion of standard debulking surgery to effect optimal cytoreduction. Destruction of diaphragma...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:Pessaries are a treatment option for pelvic organ prolapse, stress urinary incontinence (SUI), and cervical incompetence. An effective pessary is comfortable, corrects the presenting problem, does not cause adverse effects, and is easy to remove. Discomfort and poor fit limit the usefulness of pessaries for ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000002461
更新日期：2018-03-01 00:00:00
abstract：:Thirty-three gravidas with syphilis were monitored with hourly vital signs and examinations for 24 hours after treatment with benzathine penicillin G. Fifteen (45%) of the subjects had a Jarisch-Herxheimer reaction, including all three, 12 of 20 (60%), and none of ten of those with primary, secondary, and latent syphi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Response of luteinizing hormone-releasing factor (LRF) and gonadotropin levels to orally administered L-dopa and clomiphene citrate were measured in 13 healthy female volunteers. Testing was carried out during the early follicular phase of the menstrual cycle. The results indicated a suggestive but statistically nonsi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:We report three cases of rubeola during pregnancy complicated by pneumonia. All had bacterial superinfection of the lungs and a clinically mild hepatitis. One woman delivered at term and two underwent successful tocolysis, one of whom had an unexplained stillbirth 7 weeks later. Rubeola virus is not a teratogen, altho...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVE:To compare the effects of treatment with nicardipine and metoprolol in patients with hypertension during pregnancy. METHODS:One hundred pregnant patients with mild or moderate hypertension followed at the Centre Hospitalier Intercommunal de Créteil (France) were randomly allocated to treatment with either ni...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-09-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that maternal oral hydration would increase the amniotic fluid (AF) index in pregnancies with normal AF. METHODS:Forty women with a normal AF index (7.0-24.0 cm) were randomized to either the control or hydration group. Women in the hydration group drank 2 L of water and returned for t...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To analyze neonatal mortality and morbidity rates at 34, 35, and 36 weeks of gestation compared with births at term over the past 18 years at our hospital and to estimate the magnitude of increased risk associated with late preterm births compared with births later in gestation. METHODS:We performed a retros...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000297311.33046.73
更新日期：2008-01-01 00:00:00
abstract：:Eight gravidas with symptomatic polyhydramnios were managed with maternal indomethacin therapy. The mean gestational age at presentation was 28.6 +/- 3.5 weeks. Only patients requiring serial amniotic fluid decompressions for rapid amniotic fluid reaccumulation were enrolled in the study. An initial amniotic fluid dec...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：:This month we focus on current research in exercise in pregnancy. Dr. Blanchette discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000658
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:The history of gynecology and surgery in America has been well documented. However, a landmark operation took place in 1856 that has gone unrecognized in modern surgical texts. CASE:William J. Baker and associates performed the first successful abdominal hysterectomy with bilateral salpingo-oophorectomy in ...
journal_title：Obstetrics and gynecology
pub_type： 历史文章,杂志文章
doi：10.1097/01.AOG.0000187944.96000.52
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:To characterize risk and timing of postpartum stroke readmission after delivery hospitalization discharge. METHODS:The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk of readmission fo...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000002372
更新日期：2018-01-01 00:00:00
abstract：:Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in health care professionals at low risk for such conditions except for their work. Despite li...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000004021
更新日期：2020-10-01 00:00:00
abstract：:Methods to prevent perineal trauma during childbirth include avoiding episiotomy and forceps delivery and slowing delivery of the head to allow the perineum time to stretch. Each intervention can lengthen the second stage of labor and change the biophysical stresses on infants and the pelvic floor. Available evidence ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(99)00609-2
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:To determine how long fetal nucleated cells can be detected in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage, using fluorescence in situ hybridization or polymerase chain reaction. METHODS:Nucleated cells with Y chromosomes were analyzed in 90 blood samples using fluorescence i...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(94)00414-9
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To investigate vascular reactivity in women's cerebral arteries from reproductive age to postmenopause. METHODS:The pulsatility index (PI) was measured cross-sectionally in the internal carotid and middle cerebral arteries of 120 women, using a Doppler ultrasound system. Fifteen women were enrolled in each o...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(96)00119-6
更新日期：1996-07-01 00:00:00
