The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer.


OBJECTIVE:To determine the association between pretreatment platelet count and survival in women with stage IB cervical cancer. METHODS:Clinical records were reviewed for 219 women with stage IB cervical cancer treated by radical hysterectomy from 1971-1984. Univariate and multivariate analyses were performed to identify clinicopathologic variables associated with poor survival. Survival as a function of the preoperative platelet count was analyzed further and corrected for known prognostic factors. RESULTS:The cumulative 5-year survival of women with a preoperative platelet count greater than 300,000/microL (n = 85) was 65%, as compared to 84% for a count equal to or less than 300,000/microL (n = 134) (P = .004). Univariate Cox regression analysis revealed non-white race, large lesion size (greater than 4 cm), platelet count greater than 300,000/microL, and the presence of nodal metastases to be factors related to poor prognosis. A comparison of patients with platelet counts of 300,000/microL or less and patients with platelet counts greater than 300,000/microL revealed no difference with regard to race, nodal metastases, and median age. However, a larger percentage of women with a platelet count greater than 300,000/microL had large lesion size (29 of 60, versus 32 of 114 with a count of 300,000/microL or less). In a multivariate analysis, after adjusting for age, race, the presence of nodal metastases, and lesion size, high platelet count was still associated with poor prognosis (P = .04). CONCLUSION:An elevated platelet count is an independent prognostic factor for poor survival in patients with early-stage cervical cancer.


Obstet Gynecol


Rodriguez GC,Clarke-Pearson DL,Soper JT,Berchuck A,Synan I,Dodge RK


Has Abstract


1994-03-01 00:00:00












  • Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.

    abstract::Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in health care professionals at low risk for such conditions except for their work. Despite li...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Harrison R,Huh W

    更新日期:2020-10-01 00:00:00

  • Physiologic estradiol replacement therapy and cardiac structure and function in normal postmenopausal women: a randomized, double-blind, placebo-controlled, crossover trial.

    abstract:OBJECTIVE:To assess the effect of estradiol (E2) replacement therapy on cardiac structure and function in healthy postmenopausal women. METHODS:We conducted a randomized, double-blind, placebo-controlled, crossover study of 31 healthy postmenopausal female volunteer study subjects (55-65 years) using 12 weeks of micro...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Snabes MC,Payne JP,Kopelen HA,Dunn JK,Young RL,Zoghbi WA

    更新日期:1997-03-01 00:00:00

  • Toward the ethical evaluation and use of maternal-fetal surgery.

    abstract:BACKGROUND:Important clinical, social, and ethical questions are associated with the evaluation and use of surgical approaches aimed at correcting fetal anatomic abnormalities. In particular, the expansion of maternal-fetal surgery to ameliorate nonlethal fetal conditions has intensified the need to address issues abou...

    journal_title:Obstetrics and gynecology

    pub_type: 共识发展会议,杂志文章,评审


    authors: Lyerly AD,Gates EA,Cefalo RC,Sugarman J

    更新日期:2001-10-01 00:00:00

  • A randomized, double-blind, placebo-controlled, cross-over trial to assess the side effects of medroxyprogesterone acetate in hormone replacement therapy.

    abstract::Cyclic progestin therapy has been widely advocated as an adjunct to postmenopausal estrogen replacement therapy to reduce the risk of endometrial carcinoma. Acceptance of this approach, however, appears to have preceded detailed evaluation of possible adverse side effects of progestins that could result in patient non...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kirkham C,Hahn PM,Van Vugt DA,Carmichael JA,Reid RL

    更新日期:1991-07-01 00:00:00

  • A Missed Opportunity for U.S. Perinatal Human Immunodeficiency Virus Elimination: Pre-exposure Prophylaxis During Pregnancy.

    abstract:OBJECTIVE:To estimate the proportion of women at increased risk of sexual human immunodeficiency virus (HIV) acquisition during pregnancy in a high HIV incidence urban setting to identify those who may be eligible for pre-exposure prophylaxis. METHODS:We conducted a retrospective cohort study of women who received pre...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Fruhauf T,Coleman JS

    更新日期:2017-10-01 00:00:00

  • Is routine hemoglobin and hematocrit testing on admission to labor and delivery needed?

    abstract:OBJECTIVE:Testing hemoglobin and hematocrit values in labor and delivery at term is a routine practice at many centers. This necessity was evaluated by comparing values obtained at 26-28 weeks versus those obtained at term. MATERIALS:This is a prospective, observational study. All patients at least 37 weeks presenting...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Sherard GB 3rd,Newton ER

    更新日期:2001-12-01 00:00:00

  • Risk of large-for-gestational-age newborns in women with gestational diabetes by race and ethnicity and body mass index categories.

    abstract:OBJECTIVE:To compare the prevalence of large-for-gestational-age (LGA) newborns across categories of body mass index (BMI) in five racial and ethnic groups. METHODS:This cohort study examined 7,468 women with gestational diabetes mellitus (GDM) who delivered a live newborn between 1995 and 2006 at Kaiser Permanente No...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Sridhar SB,Ferrara A,Ehrlich SF,Brown SD,Hedderson MM

    更新日期:2013-06-01 00:00:00

  • Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial.

    abstract:OBJECTIVE:To assess the efficacy and safety of an oral formulation of tranexamic acid for the treatment of heavy menstrual bleeding. METHODS:Adult women with heavy menstrual bleeding (mean menstrual blood loss 80 mL or more per cycle) were enrolled in a double-blind, placebo-controlled study. After two pretreatment me...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lukes AS,Moore KA,Muse KN,Gersten JK,Hecht BR,Edlund M,Richter HE,Eder SE,Attia GR,Patrick DL,Rubin A,Shangold GA

    更新日期:2010-10-01 00:00:00

  • Placental insufficiency is characterized by platelet activation in the fetus.

    abstract:OBJECTIVE:To investigate whether activation of circulating platelets was present in the fetal and maternal circulation in cases with vascular disease in the fetal-umbilical-placental circulation as identified by umbilical artery Doppler study. METHODS:We studied 20 mother-fetus pairs with an abnormal umbilical artery ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Trudinger B,Song JZ,Wu ZH,Wang J

    更新日期:2003-05-01 00:00:00

  • Development of DES-associated clear-cell carcinoma: the importance of regular screening.

    abstract::Because the rate of malignancies in young women exposed in utero to diethylstilbesterol (DES) is low, appropriate population screening methods have not been established. A case is presented that is believed to represent the first reported instance of a DES-exposed daughter who developed clear cell adenocarcinoma of th...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Anderson B,Watring WG,Edinger DD Jr,Small EC,Netland AT,Safaii H

    更新日期:1979-03-01 00:00:00

  • Correlation of uterine activity using the Term Guard monitor versus standard external tocodynamometry compared with the intrauterine pressure catheter.

    abstract::Uterine activity monitoring to detect preterm contractions and thus to manage patients in active labor is valuable to the clinician. Uterine activity measured by external devices using the guard ring principle or by standard tocodynamometers has been shown to be accurate concerning the frequency of uterine activity as...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hess LW,McCaul JF,Perry KG,Howard PR,Morrison JC

    更新日期:1990-07-01 00:00:00

  • Intimate partner violence and maternal cigarette smoking before and during pregnancy.

    abstract:OBJECTIVE:To determine the association of intimate partner violence with maternal cigarette smoking before and during pregnancy. METHODS:Data were obtained for 196,391 U.S. mothers who delivered live neonates from 2004-2008 and completed the Pregnancy Risk Assessment Monitoring System survey 2-9 months postpartum. Int...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Cheng D,Salimi S,Terplan M,Chisolm MS

    更新日期:2015-02-01 00:00:00

  • Initiation of human parturition. III. Fetal membrane content of prostaglandin E2 and F2alpha precursor.

    abstract::Unesterified arachidonic acid is the obligatory precursor of the prostaglandins (PG), PGF2alpha and PGE2. In order to ascertain whether or not the human fetal membranes could represent a storage site for prostaglandin(s) precursor, the fatty acid content of human fetal membranes was measured. Approximately 20% of the ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Schwarz BE,Schultz FM,Macdonald PC,Johnston JM

    更新日期:1975-11-01 00:00:00

  • Barriers to Evidence-Based Transgender Care: Knowledge Gaps in Gender-Affirming Hysterectomy and Oophorectomy.

    abstract::Reversal of gender-discriminatory insurance coverage policies has led to a substantial increase in access to gender-affirming surgical care in the United States over the past 20 years. Although the evidence supports the safety, feasibility, and medical necessity of gender-affirming hysterectomy and oophorectomy, there...

    journal_title:Obstetrics and gynecology

    pub_type: 社论


    authors: Reilly ZP,Fruhauf TF,Martin SJ

    更新日期:2019-10-01 00:00:00

  • Variables associated with postoperative deep venous thrombosis: a prospective study of 411 gynecology patients and creation of a prognostic model.

    abstract::Deep venous thrombosis is a major complication following gynecologic surgery. Assessing a patient's risk of developing deep venous thrombosis is important for patient selection and in choosing appropriate prophylactic methods. Four hundred eleven patients undergoing major gynecologic surgery were evaluated prospective...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Clarke-Pearson DL,DeLong ER,Synan IS,Coleman RE,Creasman WT

    更新日期:1987-02-01 00:00:00

  • Prevalence of urinary incontinence and associated risk factors in postmenopausal women. Heart & Estrogen/Progestin Replacement Study (HERS) Research Group.

    abstract:OBJECTIVE:To determine the prevalence of stress, urge, and mixed urinary incontinence and associated risk factors in postmenopausal women. METHODS:Before enrollment in a 4-year, randomized trial of combination hormone therapy to prevent coronary heart disease, 2763 participants completed questionnaires on prevalence a...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Brown JS,Grady D,Ouslander JG,Herzog AR,Varner RE,Posner SF

    更新日期:1999-07-01 00:00:00

  • Renal cell carcinoma in pregnancy: report of three cases and review of the literature.

    abstract:BACKGROUND:Renal cell carcinoma is a potentially fatal tumor that occasionally presents during pregnancy. Based on our experience with three patients and a review of the recent cases in the literature, we believe there has been a change in presentation of this lesion over that described in previous reviews. CASES:Two ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Smith DP,Goldman SM,Beggs DS,Lanigan PJ

    更新日期:1994-05-01 00:00:00

  • Placenta previa percreta with bladder invasion.

    abstract:BACKGROUND:Although the clinical presentation and imaging techniques can raise suspicion for placenta previa percreta, this potentially catastrophic condition may remain undiagnosed or its extent underappreciated until delivery. The decision to proceed with definitive surgery in cases of placenta previa percreta should...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Leaphart WL,Schapiro H,Broome J,Welander CE,Bernstein IM

    更新日期:1997-05-01 00:00:00

  • Hypervolemic pulmonary edema and severe coagulopathy after intrauterine dextran instillation.

    abstract::A healthy young woman with recurrent spontaneous abortion and septate uterus underwent hysteroscopic metroplasty with intracavitary instillation of 1350 mL of 10% dextran 40 in normal saline. After the operation, the patient developed acute hypervolemic pulmonary edema and severe coagulopathy due to temporary impairme...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Vercellini P,Rossi R,Pagnoni B,Fedele L

    更新日期:1992-05-01 00:00:00

  • Maternal blood C-reactive protein, white blood cell count, and temperature in preterm labor: a comparison with amniotic fluid white blood cell count.

    abstract:OBJECTIVE:To compare the diagnostic and prognostic performance of maternal blood C-reactive protein, white blood cell count (WBC), and temperature with that of amniotic fluid (AF) WBC in preterm labor. METHODS:One hundred two women with preterm labor and intact membranes were studied. Maternal blood was collected to m...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Yoon BH,Yang SH,Jun JK,Park KH,Kim CJ,Romero R

    更新日期:1996-02-01 00:00:00

  • Determinants of postoperative outcomes of female genital fistula repair surgery.

    abstract:OBJECTIVE:To determine predictors of fistula repair outcomes 3 months postsurgery. METHODS:We conducted a multicountry prospective cohort study between 2007 and 2010. Outcomes, measured 3 months postsurgery, included fistula closure and residual incontinence in women with a closed fistula. Potential predictors include...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Barone MA,Frajzyngier V,Ruminjo J,Asiimwe F,Barry TH,Bello A,Danladi D,Ganda SO,Idris S,Inoussa M,Lynch M,Mussell F,Podder DC

    更新日期:2012-09-01 00:00:00

  • Pregnancy outcome after intra-abdominal bleeding due to placenta percreta at 14 weeks of gestation.

    abstract:BACKGROUND:With the rising rate of cesarean deliveries, the rate of placenta previa and placenta percreta will rise concomitantly resulting in a greater incidence of severe complications. CASE:This case report describes a pregnancy with a massive intra-abdominal bleeding due to placenta percreta at 14 weeks of gestati...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Roeters AE,Oudijk MA,Heydanus R,Bruinse HW

    更新日期:2007-02-01 00:00:00

  • Technology Assessment No. 10: single-incision laparoscopy.

    abstract::Single-incision laparoscopy is a minimally invasive technique that decreases the number of operative sites used in traditional laparoscopic surgery to one skin incision, with the potential advantages of improving cosmesis and decreasing postoperative pain. There are limited data to demonstrate the safety and feasibili...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章



    更新日期:2013-08-01 00:00:00

  • Presumed antepartum amniotic fluid embolism.

    abstract:BACKGROUND:Amniotic fluid embolism is seldom recognized in nonperipartum patients. The pathophysiology is uncertain and diagnosis imprecise, making management after stabilization difficult. CASE:A 37-year-old woman at 28 weeks' gestation presented with signs and symptoms consistent with amniotic fluid embolism includi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Kent KJ,Cooper BC,Thomas KW,Zlatnik FJ

    更新日期:2003-09-01 00:00:00

  • Misoprostol compared with laminaria before early second-trimester surgical abortion: a randomized trial.

    abstract:OBJECTIVE:To compare the efficacy and acceptability of same-day misoprostol and overnight laminaria for cervical ripening before early second-trimester surgical abortion. METHODS:We performed a randomized, double-blinded, controlled trial comparing 400 microg of vaginal misoprostol, given 3-4 hours preoperatively, wit...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goldberg AB,Drey EA,Whitaker AK,Kang MS,Meckstroth KR,Darney PD

    更新日期:2005-08-01 00:00:00

  • Conservative surgery for endometriosis in the infertile couple.

    abstract::Sixty-five infertile patients with moderate or severe endometriosis were treated with conservative surgery. Acosta's classification was used to demonstrate the extent of disease. In 48 women whose partners were normally fertile, 65% conceived, and in 17 whose partners were deficient, 35% achieved pregnancy. The extent...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Sadigh H,Naples JD Jr,Batt RE

    更新日期:1977-05-01 00:00:00

  • Committee Opinion No. 677 Summary: Antenatal Corticosteroid Therapy for Fetal Maturation.

    abstract::Corticosteroid administration before anticipated preterm birth is one of the most important antenatal therapies available to improve newborn outcomes. A single course of corticosteroids is recommended for pregnant women between 24 0/7 weeks and 33 6/7 weeks of gestation, including for those with ruptured membranes and...

    journal_title:Obstetrics and gynecology

    pub_type: 共识发展会议,杂志文章



    更新日期:2016-10-01 00:00:00

  • Goodpasture syndrome in a pregnant woman.

    abstract:BACKGROUND:Goodpasture syndrome, an immunologic disorder characterized by glomerulonephritis and pulmonary hemorrhage, rarely presents in pregnancy. CASE:We describe a patient who was diagnosed with Goodpasture syndrome in her second trimester. She required daily hemodialysis, intermittent plasmapheresis, and immunosu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Vasiliou DM,Maxwell C,Shah P,Sermer M

    更新日期:2005-11-01 00:00:00

  • Serum C-reactive protein and Chlamydia trachomatis antibodies in preterm delivery.

    abstract:OBJECTIVE:To assess the association between Chlamydia trachomatis antibodies, antibodies to C trachomatis heat shock proteins 60 and 10, and C-reactive protein (CRP) levels in maternal serum measured by highly sensitive CRP assay during the first trimester and spontaneous preterm delivery before 37 weeks of gestation. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Karinen L,Pouta A,Bloigu A,Koskela P,Paldanius M,Leinonen M,Saikku P,Jêrvelin MR,Hartikainen AL

    更新日期:2005-07-01 00:00:00

  • Serum 17 alpha-hydroxyprogesterone in patients with gestational trophoblastic neoplasms.

    abstract::Serum 17alpha-hydroxprogesterone (17-OHP), progesterone (P), and human chorionic gonadotropin (hCG) levels were measured by specific radioimmunoassay in 19 patients undergoing laparoscopy or laparotomy with either unevacuated molar pregnancy or nonmetastatic gestational trophoblastic neoplasms (GTN), in 10 normal preg...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Osathanondh R,Goldstein DP,Tulchinsky D,Finn AE

    更新日期:1977-01-01 00:00:00