Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism.

Abstract:

:Fenfluramine therapy has been reported to improve behavior in infantile autism and has been associated with a decrease in abnormally increased blood serotonin content. The primary central effect has not been proved to be serotonergic. Beta-endorphin is involved in the anorexic effect of fenfluramine and may play a role in autism. Nine children with infantile autism were treated with fenfluramine in double-blind, placebo-crossover design. Transient anorexia was the only adverse effect. Autistic behavior was reported to improve in three patients, but objective psychometric tests were unchanged. Beta-endorphin-like immunoreactivity was determined in lumbar cerebrospinal fluid of patients during and before or after treatment with fenfluramine and then was compared to normal controls. Beta-endorphin was elevated significantly in the baseline autistic group (p less than .005) and was reduced toward control values during fenfluramine treatment. The results are consistent with a role for beta-endorphin in infantile autism and in the mechanism of fenfluramine treatment.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Ross DL,Klykylo WM,Hitzemann R

doi

10.1016/0887-8994(87)90032-4

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

83-6

issue

2

eissn

0887-8994

issn

1873-5150

pii

0887-8994(87)90032-4

journal_volume

3

pub_type

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