Abstract:
:Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.
journal_name
Pak J Med Scijournal_title
Pakistan journal of medical sciencesauthors
Rasool M,Khan SR,Malik A,Khan KM,Zahid S,Manan A,Qazi MH,Naseer MIdoi
10.12669/pjms.303.4985subject
Has Abstractpub_date
2014-05-01 00:00:00pages
466-71issue
3eissn
1682-024Xissn
1681-715Xjournal_volume
30pub_type
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Pakistan journal of medical sciences
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.345.15262
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pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.3.834
更新日期:2019-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.293.3629
更新日期:2013-05-01 00:00:00
abstract:Objective:To compare the efficacy of oral Labetalol versus oral Nifedipine for the treatment of postpartum hypertension. Methods:A prospective randomized controlled trial with parallel assignment was conducted in the department of Obstetrics and Gynecology, Dow University of Health Sciences Karachi, Pakistan, 124 pati...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.5.812
更新日期:2019-09-01 00:00:00
abstract:Objective:To evaluate the association of miR-196a rs11614913 C/T genetic variation and its target gene annexin A1 mRNA expression with breast cancer risk in Pakistani female ethnicities. Methods:This case control study, conducted from March 2017 to November 2018 included 295 breast cancer patients, 295 controls of thr...
journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.6.1322
更新日期:2019-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.36.ICON-Suppl.1717
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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pub_type: 杂志文章
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doi:10.12669/pjms.36.7.2793
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.1.95
更新日期:2019-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.346.15932
更新日期:2018-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.346.15942
更新日期:2018-11-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.35.5.478
更新日期:2019-09-01 00:00:00
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journal_title:Pakistan journal of medical sciences
pub_type: 杂志文章
doi:10.12669/pjms.326.11391
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.12669/pjms.304.4810
更新日期:2014-07-01 00:00:00