Abstract:
BACKGROUND/AIM:Previous studies have revealed that zinc finger and BTB domain-containing 7A (ZBTB7A), an important proto-oncogene, plays multiple roles in carcinogenesis and is up-regulated in several human malignancies. However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this study, we investigated the differential expression of ZBTB7A in CRC cell lines and tissues. MATERIALS AND METHODS:Expression levels of ZBTB7A mRNA and protein were examined in CRC cell lines. ZBTB7A protein expression was also evaluated in tissue samples of normal colonic mucosa, high-grade dysplasia, and CRC using immunohistochemical staining. RESULTS:All CRC cell lines exhibited significantly higher ZBTB7A mRNA expression levels than did normal colonic epithelial cells. The ZBTB7A protein expression levels were clearly higher in the CRC cell lines than in the normal colonic epithelial cells. Consistent with the cell line data, immunostaining revealed that there were significant differences in ZBTB7A protein expression between tissue samples of CRC and normal colonic mucosa (p=0.048) and high-grade dysplasia (p=0.015). In addition, metastatic CRC exhibited significantly higher ZBTB7A protein expression levels than primary CRC (p=0.027). CONCLUSION:We demonstrated that ZBTB7A expression is up-regulated in CRC cell lines and tissues. Our data suggest that ZBTB7A is involved in the development and progression of CRC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Joo JW,Kim HS,Do SI,Sung JYdoi
10.21873/anticanres.12522subject
Has Abstractpub_date
2018-05-01 00:00:00pages
2787-2792issue
5eissn
0250-7005issn
1791-7530pii
38/5/2787journal_volume
38pub_type
杂志文章abstract:BACKGROUND/AIM:There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro. MATERIALS AND METHODS:Resected lung cancer specimens were ...
journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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doi:
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doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
更新日期:2014-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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