当前位置： SCI文献检索 > DOMESTIC ANIMAL ENDOCRINOLOGY期刊下所有文献 > Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens.

Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens.

Abstract：

:In this study, immunization against chicken leptin receptor (cLEPR) extracellular domain (ECD) was applied to investigate leptin regulation and LEPR biofunction in growing chicken pullets. A recombinant protein (cLEPR ECD) based on the cLEPR complemenary DNA sequence corresponding to the 582nd to 796th amino acid residues of cLEPR mature peptide was prepared and used as antigen. Immunization against cLEPR ECD in growing chickens increased anti-cLEPR ECD antibody titers in blood, enhanced proportions of phosphorylated janus kinase 2 (JAK2) and served as signal transducer and activator of transcription 3 (STAT3) protein in liver tissue. Chicken live weight gain and abdominal fat mass were significantly decreased (P < 0.05), but feed intake was stimulated by cLEPR ECD immunization (P < 0.05). The treatment also upregulated the gene expression levels of lepR, AMP-activated protein kinase (AMPK), acetyl CoA carboxylase-2 (ACC2), and uncoupling protein 3 (UCP3) in liver, abdominal fat, and breast muscle (P < 0.05) but decreased fasn expression levels (P < 0.01). Apart from that of lepR, the expression of appetite-regulating genes, such as orexigenic genes, agouti-related peptide (AgRP) and neuropeptide Y (NPY), were upregulated (P < 0.01), whereas the anorexigenic gene proopiomelanocortin (POMC) was downregulated in the hypothalamic tissue of cLEPR-immunized pullets (P < 0.01). Blood concentrations of metabolic molecules, such as glucose, triglycerides, and very-low-density lipoprotein, were significantly decreased in cLEPR-immunized pullets but those of cholesterol, high-density lipoprotein, and low-density lipoprotein increased. These results demonstrate that antibodies to membrane proximal cLEPR ECD enhance cLEPR signal transduction, which stimulates metabolism and reduces fat deposition in chickens.

journal_name

Domest Anim Endocrinol

journal_title

Domestic animal endocrinology

authors

Lei MM,Wu SQ,Shao XB,Li XW,Chen Z,Ying SJ,Shi ZD

doi

10.1016/j.domaniend.2014.09.001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

55-64

eissn

0739-7240

issn

1879-0054

pii

S0739-7240(14)00082-4

journal_volume

50

pub_type

杂志文章

相关文献

DOMESTIC ANIMAL ENDOCRINOLOGY文献大全
  • Relationship between serum adiponectin concentration, body condition score, and peripheral tissue insulin response of dairy cows during the dry period.

    abstract：:The aim of the present study was to describe the relationship between serum adiponectin concentration and peripheral tissue insulin response in dairy cows with a variable body condition score (BCS) during the dry period. Cows were selected at the beginning of the dry period based on BCS (BCS <3.75, n = 4; BCS >3.75, n...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2016.12.004

    authors： De Koster J,Urh C,Hostens M,Van den Broeck W,Sauerwein H,Opsomer G

    更新日期：2017-04-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of the glucagon-like peptide-1 analog liraglutide in healthy cats.

    abstract：:Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Glucagon-like peptide-1 also increases beta cell mass and satiation while decelerating gastric emptying. Liraglutide is a fatty-acid derivative of GLP-1 with a ...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2014.12.001

    authors： Hall MJ,Adin CA,Borin-Crivellenti S,Rudinsky AJ,Rajala-Schultz P,Lakritz J,Gilor C

    更新日期：2015-04-01 00:00:00

  • Study of the hepatic growth hormone (GH) receptor at different ages in chickens selected for a good feed conversion (FC) and a fast weight gain (GL).

    abstract：:The influence of genetic selection for improved feed conversion (FC) and fast growth (GL) in broiler chickens, on the hepatic growth hormone receptor was investigated as a function of age. Selection for improved feed conversion resulted in lean chickens, whereas selection for fast growth resulted in fat chickens. Grow...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/0739-7240(93)90024-6

    authors： Vanderpooten A,Janssens W,Buyse J,Leenstra F,Berghman L,Decuypere E,Kühn ER

    更新日期：1993-07-01 00:00:00

  • Saliva collection by using filter paper for measuring cortisol levels in dogs.

    abstract：:Four experiments were conducted to evaluate the accuracy and reliability of noninvasive evaluation of cortisol in saliva of dogs. In experiment 1, we measured the cortisol concentration in the filter paper on which 250-μL cortisol solutions had been quantitatively pipetted and in filter papers dipped in cortisol solut...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2013.09.008

    authors： Oyama D,Hyodo M,Doi H,Kurachi T,Takata M,Koyama S,Satoh T,Watanabe G

    更新日期：2014-01-01 00:00:00

  • Differences in the expression of luteinizing hormone and follicle-stimulating hormone receptors in the lower urinary tract between intact and gonadectomised male and female dogs.

    abstract：:Receptors for LH (LHR) and FSH (FSHR) are expressed in the canine lower urinary tract (LUT). As gonadectomy results in an increase in plasma LH and FSH, the objective of this study was to determine whether there are any differences in the expression of LHR and FSHR in the LUT between intact and gonadectomised dogs. Fo...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2007.09.005

    authors： Ponglowhapan S,Church DB,Khalid M

    更新日期：2008-05-01 00:00:00

  • Melatonin improves the motility and DNA integrity of frozen-thawed ram spermatozoa likely via suppression of mitochondrial superoxide production.

    abstract：:The ability of the neurohormone melatonin to ameliorate cryopreservation-induced damage to spermatozoa has been demonstrated in several domestic species. However, it is unclear how these protective effects are conferred, with improvements in sperm quality ambiguously attributed to the general antioxidant activity of m...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2020.106516

    authors： Pool KR,Rickard JP,de Graaf SP

    更新日期：2021-01-01 00:00:00

  • Changes in adrenal cortisol secretion as reflected in the urinary cortisol/creatinine ratio in dogs.

    abstract：:In Experiment 1, voided urine samples were collected from 12 adult dogs at 0500, 1400, and 2200 hr for 4 days. Cortisol was measured in unextracted urine by radioimmunoassay, creatinine by spectrophotometry, and the cortisol/creatinine ratio (UCCR) was calculated for each sample. There was considerable variation both ...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/0739-7240(90)90013-p

    authors： Jones CA,Refsal KR,Lippert AC,Nachreiner RF,Schwacha MM

    更新日期：1990-10-01 00:00:00

  • Lack of a nocturnal rise of serum melatonin in prepubertal gilts.

    abstract：:Experiments were conducted to determine if a nocturnal rise in serum melatonin occurs in prepubertal gilts and whether acute exposure of gilts to light during the dark period abruptly reduces serum concentrations of melatonin. In experiment 1, 12 prepubertal crossbred gilts (Duroc x Hampshire x Chester White x Yorkshi...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/0739-7240(92)90029-w

    authors： Diekman MA,Brandt KE,Green ML,Clapper JA,Malayer JR

    更新日期：1992-04-01 00:00:00

  • Tissue-specific expression and circulating concentrations of nesfatin-1 in domestic animals.

    abstract：:Nesfatin-1 is a naturally occurring 82-amino acid protein encoded in the precursor nucleobindin-2 (NUCB2) and has been implicated in multiple physiological functions, including food intake and blood glucose regulation. This study aimed to characterize nesfatin-1 in domestic species, especially cats (Felis catus), dogs...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2018.04.006

    authors： Morton KA,Hargreaves L,Mortazavi S,Weber LP,Blanco AM,Unniappan S

    更新日期：2018-10-01 00:00:00

  • Leptin: a possible metabolic signal affecting reproduction.

    abstract：:Since its discovery in 1994, leptin, a protein hormone synthesized and secreted by adipose tissue, has been shown to regulate feed intake in several species including sheep and pigs. Although a nimiety of information exists regarding the physiological role of leptin in rodents and humans, the regulation and action of ...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0739-7240(01)00120-5

    authors： Spicer LJ

    更新日期：2001-11-01 00:00:00

  • Neuroimmunoregulation and natural immunity.

    abstract：:The development and function of the immune system is regulated by neuroendocrine factors. Immune function may be divided into adaptive and natural immunity. Adaptive immune responses are driven by specific determinants of the antigen (epitopes), require 5-10 d to fully develop, and show an accelerated or memory respon...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0739-7240(98)00015-0

    authors： Berczi I,Chow DA,Sabbadini ER

    更新日期：1998-09-01 00:00:00

  • Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats.

    abstract：:An increasing demand for calcium during pregnancy and lactation can result in both clinical and subclinical hypocalcemia during the early lactation period in several mammalian species, in particular the dairy cow. Serotonin (5-HT) was recently identified as a regulator of lactation and bone turnover. The purpose of th...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2013.01.005

    authors： Laporta J,Peters TL,Weaver SR,Merriman KE,Hernandez LL

    更新日期：2013-05-01 00:00:00

  • Estradiol-17beta and linseed meal interact to alter visceral organ mass and hormone concentrations from ovariectomized ewes.

    abstract：:To evaluate the estrogenic potential of secoisolariciresinol diglycoside (SDG) found in linseed meal (LSM) on visceral organ mass, IGF-I, and thyroid hormone (T(3) and T(4)) concentrations, 48 multiparous, ovariectomized ewes (54.6 +/- 1.1 kg) were used in a 3 x 4 factorial arrangement. Main effects were length of LSM...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2009.05.001

    authors： O'Neil MR,Lardy GP,Wilson ME,Lemley CO,Reynolds LP,Caton JS,Vonnahme KA

    更新日期：2009-10-01 00:00:00

  • Effect of phthalate esters on the secretion of prostaglandins (F2alpha and E2) and oxytocin in cultured bovine ovarian and endometrial cells.

    abstract：:The influence of phthalate esters di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) on uterine prostaglandin (PGF2alpha and PGE2) and ovarian oxytocin secretion was investigated. Endometrial, granulosa, and luteal cells from cows on days 8-12 of the estrous cycle were treated with DEHP or MEHP (0...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2010.03.002

    authors： Wang X,Shang L,Wang J,Wu N,Wang S

    更新日期：2010-08-01 00:00:00

  • Separation of protein and lactose intake over meals dissociates postprandial glucose and insulin concentrations and reduces postprandial insulin responses in heavy veal calves.

    abstract：:The present study examined, at identical daily nutrient intakes, the impact of separating protein and lactose intakes across two daily meals on the metabolic and endocrine status in heavy veal calves. Calves were assigned to one of six degrees of separating protein and lactose over the two meals (termed nutrient synch...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2007.01.003

    authors： Vicari T,van den Borne JJ,Gerrits WJ,Zbinden Y,Blum JW

    更新日期：2008-02-01 00:00:00

  • Potential role for GnRH in the synchronization of follicular emergence before the superovulatory Day 0 protocol.

    abstract：:The ability of gonadotropin-releasing hormone (GnRH) to synchronize ovulation and new follicular wave emergence before a "superovulatory Day 0" protocol was assessed in Santa Inês ewes. For estrus synchronization, a 60-mg medroxyprogesterone acetate sponge was inserted for 6 d. One day before sponge removal, 37.5-μg d...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2015.07.002

    authors： Balaro MF,Fonseca JF,Barbosa TG,Souza-Fabjan JM,Figueira LM,Teixeira TA,Carvalheira LR,Brandão FZ

    更新日期：2016-01-01 00:00:00

  • Poor maternal nutrition during gestation in sheep reduces circulating concentrations of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in offspring.

    abstract：:To determine if poor maternal nutrition alters growth, body composition, circulating growth factors, and expression of genes involved in the development of muscle and adipose of offspring, 24 Dorset and Shropshire ewes were fed either 100% (control fed), 60% (restricted fed), or 126% (over fed) of National Research Co...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2014.05.002

    authors： Hoffman ML,Rokosa MA,Zinn SA,Hoagland TA,Govoni KE

    更新日期：2014-10-01 00:00:00

  • Association of somatotropin (BST) gene polymorphism at the 5th exon with selection for milk yield in Holstein cows.

    abstract：:A selection project produced control cows from continuous matings with breed average bulls for predicted transmitting ability for milk (PTA-milk) in 1964 and select cows from matings to four of the highest PTA-milk bulls each year since 1964. Blood samples were collected in 1992 when milk yield difference of select an...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/0739-7240(96)00050-1

    authors： Lee BK,Lin GF,Crooker BA,Murtaugh MP,Hansen LB,Chester-Jones H

    更新日期：1996-07-01 00:00:00

  • Age-related changes in porcine corticosteroid-binding globulin (pCBG) as determined by an enzyme-linked immunosorbent assay.

    abstract：:The objectives of this study were to develop an assay for the direct measure of porcine corticosteroid-binding globulin (pCBG) and to confirm age-related changes in plasma pCBG concentration. Isolation and purification of pCBG from plasma was performed by affinity chromatography and HPLC-DEAE anion exchange techniques...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0739-7240(03)00011-0

    authors： Roberts MP,Kattesh HG,Baumbach GA,Gillespie BE,Godkin JD,Schneider JF,Saxton AM

    更新日期：2003-05-01 00:00:00

  • Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide.

    abstract：:Reduction in fertility is well known to be possibly related to selenium deficiencies, even if target organ for selenium action is, at present, unclear. The present study was aimed to examine whether selenium directly influences granulosa cells. Bovine granulosa cells from different size follicles were used to investig...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0739-7240(99)00059-4

    authors： Basini G,Tamanini C

    更新日期：2000-01-01 00:00:00

  • Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves.

    abstract：:Ghrelin is a gut peptide which participates in growth regulation through its somatotropic, lipogenic and orexigenic effects. Synergism of ghrelin and growth hormone-releasing hormone (GHRH) on growth hormone (GH) secretion has been reported in humans and rats, but not in domestic animals in vivo. In this study, effect...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2006.12.001

    authors： ThidarMyint H,Yoshida H,Ito T,He M,Inoue H,Kuwayama H

    更新日期：2008-01-01 00:00:00

  • Insulin-like growth factors in poultry.

    abstract：:A large amount of research, primarily in mammals, has defined to a great extent the pleiotropic effects of the IGF system on growth, development, and intermediary metabolism. Similar elucidations in poultry were hindered to some extent by the absence of native peptides (IGF-I and IGF-II) until their purification, foll...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0739-7240(97)00019-2

    authors： McMurtry JP,Francis GL,Upton Z

    更新日期：1997-07-01 00:00:00

  • Influence of brain plasmalogen changes on gonadotropin secretion from the cultured bovine anterior pituitary cells.

    abstract：:We recently discovered that the orphan G-protein-coupled receptor (GPR) 61 colocalized with GnRH receptors (GnRHRs) on the surface of most of bovine gonadotrophs. A recent study suggested that ethanolamine plasmalogen (PI) is a ligand for GPR61 in mouse neuroblastoma. Therefore, this study evaluated the hypothesis tha...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2018.04.002

    authors： Kereilwe O,Pandey K,Kadokawa H

    更新日期：2018-07-01 00:00:00

  • Downregulation of LH and FSH receptors after hCG and eCG treatments in the porcine oviduct.

    abstract：:The influence of induction of ovulation and superovulation with eCG and hCG on LH and FSH receptor levels in porcine oviducts on day 3 postcoitum was studied. In experiment I, gilts were assigned into cyclic (control; n = 5) and inseminated (n = 5) groups. In experiment II, there were 3 groups of animals: inseminated ...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.domaniend.2016.06.003

    authors： Małysz-Cymborska I,Andronowska A

    更新日期：2016-10-01 00:00:00

  • cDNA cloning and tissue-specific gene expression of ovine leptin, NPY-Y1 receptor, and NPY-Y2 receptor.

    abstract：:The physiological regulation of food intake is a critical factor in both the rate at which an animal grows and its reproductive activity. Recently, progress has been made in elucidating a complex system in which insulin, leptin, and neuropeptide Y function to monitor an animal's energy balance and regulate feed intake...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0739-7240(97)00028-3

    authors： Dyer CJ,Simmons JM,Matteri RL,Keisler DH

    更新日期：1997-09-01 00:00:00

  • Differentiation of canine adipose mesenchymal stem cells into insulin-producing cells: comparison of different culture medium compositions.

    abstract：:The aim of this study was to differentiate canine adipose-derived mesenchymal stem cells (ADMSCs) into insulin-producing cells by using culture media with different compositions to determine the most efficient media. Stem cells isolated from the fat tissues close to the bitch uterus were distributed into 6 groups: (1)...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2020.106572

    authors： Camara BOS,Ocarino NM,Bertassoli BM,Malm C,Araújo FR,Reis AMS,Jorge EC,Alves EGL,Serakides R

    更新日期：2021-01-01 00:00:00

  • Differential expression of peroxisome proliferator-activated receptors alpha and gamma gene in various chicken tissues.

    abstract：:The peroxisome proliferator-activated receptors (PPARs) are the members of superfamily of nuclear hormone receptors. A great number of studies in rodent and human have shown that PPARs were involved in the lipids metabolism. The goal of the current study was to investigate the expression pattern of PPAR genes in vario...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2004.05.003

    authors： Meng H,Li H,Zhao JG,Gu ZL

    更新日期：2005-01-01 00:00:00

  • Changes in ghrelin levels of plasma and proventriculus and ghrelin mRNA of proventriculus in fasted and refed layer chicks.

    abstract：:This is a test-report of ghrelin levels in plasma and proventriculus, the glandular portion of the avian stomach, by using a specific radioimmunoassay for acylated ghrelin, as well as the expression of the ghrelin gene in the proventriculus after a 12-h fasting period followed by a 6-h feeding period with 6-day-old la...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2006.03.006

    authors： Kaiya H,Saito ES,Tachibana T,Furuse M,Kangawa K

    更新日期：2007-05-01 00:00:00

  • Evaluation of a flash glucose monitoring system in dogs with diabetic ketoacidosis.

    abstract：:The flash glucose monitoring system (FGMS) Freestyle Libre provides estimates of blood glucose by constantly measuring the glucose concentration of the interstitial fluid through a sensor inserted in the subcutaneous space. The aim of this study was to evaluate the applicability and accuracy of the FGMS in dogs with d...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.domaniend.2020.106525

    authors： Silva DD,Cecci GRM,Biz G,Chiaro FN,Zanutto MS

    更新日期：2021-01-01 00:00:00

  • Is it time to reconsider the relative weight of sociosexual relationships compared with photoperiod in the control of reproduction of small ruminant females?

    abstract：:In goats and sheep from the temperate and subtropical latitudes, the breeding season lasts from early autumn to late winter, whereas the anestrous season lasts from late winter to late summer. In prepubertal or postpartum females, the duration of the quiescent period depends mainly on the season of parturition and of ...

    journal_title：Domestic animal endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.domaniend.2020.106468

    authors： Delgadillo JA,Hernández H,Abecia JA,Keller M,Chemineau P

    更新日期：2020-10-01 00:00:00