Abstract：
:Twenty affective disorder patients (16 bipolar and 4 unipolar) and 24 normal controls received scans with positron emission tomography (PET) using [18F]2-deoxyglucose (FDG) as a tracer. Subjects received a series of brief electrical stimuli to their right arms during FDG uptake. Patients with bipolar affective illness had significantly lower frontal to occipital glucose metabolic rate ratios (relative hypofrontality) and significantly lower metabolic rates in their basal ganglia in comparison to whole slice metabolism than normal controls. Patients with unipolar illness showed significantly higher frontal to occipital ratios, and also showed relatively decreased metabolism in the basal ganglia. All results in unipolar patients should be considered exploratory due to the small number of patients. Clinical depression ratings correlated negatively with whole slice metabolic rate.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Buchsbaum MS,Wu J,DeLisi LE,Holcomb H,Kessler R,Johnson J,King AC,Hazlett E,Langston K,Post RMdoi
10.1016/0165-0327(86)90036-4subject
Has Abstractpub_date
1986-03-01 00:00:00pages
137-52issue
2eissn
0165-0327issn
1573-2517pii
0165-0327(86)90036-4journal_volume
10pub_type
杂志文章abstract：:130 patients fulfilling DSM-III-R criteria for bipolar disorder (n = 62), bipolar disorder not otherwise specified (n = 19) and major depression (n = 49) were included in a comparative study on the occupational levels of uni- and bipolar probands and relatives. The occupational levels did not significantly differ betw...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(94)00087-p
更新日期：1995-03-14 00:00:00
abstract：:Tricyclic antidepressants have multiple sites of pharmacological actions which are responsible for their tolerability and toxicological problems as well as their efficacy. That fact has prompted the search for antidepressants with fewer sites of action. That search resulted in the serotonin selective reuptake inhibito...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(98)00222-5
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVE:The current study was designed to investigate the association between serum thyroid hormones and thyroid-stimulating hormone (TSH) levels with lipid profile in depressive disorder. METHODS:A total of 370 depressive individuals aged 18 years and above were recruited in this cross-section study. All participan...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.03.055
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Glycogen synthease kinase-3B is a key gene encoding a protein kinase which is abundant in brain, and is involved in signal transduction cascades of neuronal cell development and energy metabolism. Previous researches proposed GSK3B as a potential region for schizophrenia. METHOD:To validate the susceptibili...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.06.040
更新日期：2015-10-01 00:00:00
abstract：:The dexamethasone suppression test was administered to 40 newly admitted manic patients. Twenty-four patients (60%) had abnormal escape from suppression. There was no correlation of DST results with sex, age, age of onset, family history of affective disorder, psychosis during index episode, or duration of hospitaliza...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(84)90049-1
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Depression treatment by General Practitioners (GPs) and patient outcomes improved significantly after a comprehensive 20-h training program of GPs. This study examines whether the effects on patient outcomes are caused by the improvements in the process of care. METHODS:Seventeen GPs participated in the tra...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(03)00074-0
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Previously we found that transmission of religion from mother to adult offspring as measured by correlations on ratings of personal importance of religion and frequency of attendance at religious services was hindered by maternal depression. Concordance of denomination, a measure indicating successful transm...
journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2011.11.030
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Ketamine induces rapid and robust antidepressant effects, and many patients also describe dissociation, which is associated with antidepressant response. This follow-up study investigated whether antidepressant efficacy is uniquely related to dissociative symptom clusters. METHODS:Treatment-resistant patien...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2018.02.049
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy in resistant unipolar depression, but its efficacy in bipolar disorders has not yet been extensively investigated. Mixed episodes are reported in up to 40% of acute bipolar admissions and are associated with severe psychopathology, comorb...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.12.024
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:This study sought to determine from a recent meta-analysis of pediatric antidepressant trials if a general property of antidepressant medications--the multiple-dosing medication half-life--is associated with risks for suicidal ideation or behavior. METHODS:Relative risks for suicidal behavior (ideation, att...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析
doi：10.1016/j.jad.2008.06.018
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Depression is a major global public health concern. The aetiology of depression is partly unclear; however, intake of nutrients, such as magnesium, have been suggested to affect depressive symptoms and modify depression risk. METHODS:This research is a part of the Kuopio Ischemic Heart Disease Risk Factor (...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.12.056
更新日期：2016-03-15 00:00:00
abstract：BACKGROUND:Postnatal depression affects a significant number of parents; however, its co-occurrence in mothers and fathers has not been studied extensively. Identifying predictors and correlates of postnatal depressive symptoms can help develop effective interventions. METHODS:Questionnaires on several socio-demograph...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.10.033
更新日期：2016-01-15 00:00:00
abstract：:The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by pretreatment with the MAO inhibitor tranylcypromine (T...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(95)00056-9
更新日期：1995-12-13 00:00:00
abstract：OBJECTIVE:To examine clinical characteristics and treatment responses of patients presenting with delirium and mania to a psychiatric inpatient unit. METHOD:Chart review of 16 cases admitted to McLean Hospital with delirium and mania was conducted. We examined the demographics, psychiatric symptoms, clinical course, a...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.12.001
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To investigate the course of PTSD, depression, and current quality of life among adolescents 32-months after the 1999 Parnitha earthquake in Greece. METHODS:The follow-up was conducted among 511 adolescents originally evaluated at 3-months post-earthquake using the UCLA PTSD Reaction Index (PTSD-RI), Depress...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.04.053
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:This study aimed to test the validity of using the Hypomania Checklist-16 [HCL-16] to measure hypomania in a British adolescent community sample. Limited research is available concerning the characterization of hypomania among community adolescent samples, particularly in the UK, despite its potential import...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.08.033
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The predictors of onset of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well-characterized. However the factors that predict remission from these conditions are less clear, and the study of this area is further complicated by differing definitions of remission. METHODS:Data com...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.10.042
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:Clinical and animal studies have reported conflicting results regarding the effect of ketamine on cognitive function, although increasing evidence supports a rapid and sustained antidepressant effect of a subanesthetic dose of ketamine infusion for patients with treatment-resistant depression (TRD). However,...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.07.033
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Improved understanding how depressive symptoms change with sustained opioid use is needed. METHODS:We prospectively assessed patients 45 years or older initiating chronic opioid therapy (COT) at baseline and at 4 and 12 months, differentiating recent COT initiators (n=748) and continuing users (n=468). Leve...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.12.052
更新日期：2017-03-15 00:00:00
abstract：BACKGROUND:Asylum seekers show high prevalence of depressive disorders compared to native populations. For the assessment of depression, the Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument that has shown high validity and reliability. However, it is largely unknown whether PHQ-9 scores are comparable...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.055
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Major depressive disorder may be a heterogeneous disorder, yet melancholic depression is the most consistently described subtype, regarded as qualitatively different to non-melancholic depression in terms of cognitive and motor impairments. Eye movement studies in depression are infrequent and findings are i...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.03.018
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Suicide has become one of the most prominent concerns for public health and wellness; however, detecting suicide risk factors among individuals remains a big challenge. The aim of this study was to develop a machine learning algorithm that could effectively and accurately identify the probability of suicide ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.04.057
更新日期：2020-08-01 00:00:00
abstract：:Thirty subjects with seasonal affective disorder (SAD) and three subjects with a non-seasonal depression had a trial of phototherapy in an open assessment of the feasibility of phototherapy in clinical practice. 43% of the SAD subjects met the criteria for 'successful treatment', but none of the subjects with non-seas...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(90)90069-k
更新日期：1990-02-01 00:00:00
abstract：OBJECTIVE:A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in e...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2012.02.017
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Anger attacks, characterized by sudden episodes of intense anger with autonomic arousal, have been described in patients with major depressive disorder (MDD). This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression. METHODS:Using the questionnaire ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(02)00451-2
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA an...
journal_title：Journal of affective disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jad.2009.09.001
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Late-life depression often remains undetected in primary care. However, as there is evidence that GPs do identify those with the most severe and persistent disorders, it is important to know more about the prognosis of depressive disorders that are not detected by GPs. METHODS:A one-year follow-up study of ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.06.006
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Suicide is the second leading cause of death in adolescents. Screening for persons at risk usually includes asking about suicidal ideation, which is considered inappropriate in some societies and situations. To avoid directly addressing suicide, this paper investigates whether the Health Behaviour in School-...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.08.025
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Many studies have demonstrated that major depression is related to an activation of the inflammatory response system (IRS) with an increased production of proinflammatory cytokines. It has been shown that tricyclic antidepressants and serotonin reuptake inhibitors suppress the activation of the IRS in depres...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(99)00076-2
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) has been associated with developing mental disorders in Western populations, but this association is poorly studied in Asians. Hence, using insurance claims data, this study evaluated the anxiety risk in women with PCOS. METHODS:Using Taiwan's National Health Insurance Resea...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.04.032
更新日期：2020-08-01 00:00:00
