Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe.

Abstract:

:We used fMRI in 35 healthy participants to investigate how two neighbouring subregions in the lateral anterior temporal lobe (LATL) contribute to semantic matching and object naming. Four different levels of processing were considered: (A) recognition of the object concepts; (B) search for semantic associations related to object stimuli; (C) retrieval of semantic concepts of interest; and (D) retrieval of stimulus specific concepts as required for naming. During semantic association matching on picture stimuli or heard object names, we found that activation in both subregions was higher when the objects were semantically related (mug-kettle) than unrelated (car-teapot). This is consistent with both LATL subregions playing a role in (C), the successful retrieval of amodal semantic concepts. In addition, one subregion was more activated for object naming than matching semantically related objects, consistent with (D), the retrieval of a specific concept for naming. We discuss the implications of these novel findings for cognitive models of semantic processing and left anterior temporal lobe function.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Sanjuán A,Hope TM,Jones 'P,Prejawa S,Oberhuber M,Guerin J,Seghier ML,Green DW,Price CJ

doi

10.1016/j.neuropsychologia.2014.12.004

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

153-62

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(14)00458-8

journal_volume

76

pub_type

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