Abstract：
:This study examined the performance of 32 normal subjects and 39 patients with focal lesions of the frontal lobes on two simple timing tasks-responding in time with a tone that regularly repeated at a rate of once every 1.5s, and then maintaining the same regular response rhythm without any external stimulus. The hypothesis was that lesions to the right prefrontal cortex would disrupt timing performance. The two main findings were (1) an abnormally high variability in the timing performance (both self-timed and tone-timed) of patients with lesions to the right lateral frontal lobe, particularly involving Brodmann area 45 and subjacent regions of the basal ganglia; (2) an increase in the variability of timing performance as the task continued in patients with lesions to the superior medial regions of the frontal lobe. These findings indicate that the right lateral frontal lobe is crucially involved in the ongoing control of timed behavior, either because of its role in generating time intervals or in monitoring the passage of these intervals. In contrast, the superior medial regions of the frontal lobe are necessary to maintain consistent timing performance over prolonged periods of time.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Picton TW,Stuss DT,Shallice T,Alexander MP,Gillingham Sdoi
10.1016/j.neuropsychologia.2005.10.002subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1195-209issue
7eissn
0028-3932issn
1873-3514pii
S0028-3932(05)00317-9journal_volume
44pub_type
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