Abstract:
BACKGROUND:Schizophrenia and autism share many behavioral and neurological similarities, including altered white matter tract structure. However, because schizophrenia and autism are rarely compared directly, it is difficult to establish whether white matter abnormalities are disorder-specific or are common across these disorders that share some symptomatology. METHODS:In the current study, we compared white matter water diffusion using tensor imaging in 25 adults with autism, 15 adults with schizophrenia, all with IQ scores above 88, and 19 neurotypical adults. RESULTS:Although the three groups evinced no statistically significant differences in measures of fractional anisotropy (FA), the schizophrenia group showed significantly greater mean diffusivity (MD; Cohen's d > 0.77), due to greater radial diffusivity (RD; Cohen's d > 0.92), compared to both the autism and control groups. This effect was evident across the brain rather than specific to a particular tract. CONCLUSIONS:The greater MD and RD in schizophrenia appears to be diagnosis-specific. The altered diffusion may reflect subtle abnormalities in myelination, which could be a potential mechanism underlying the widespread behavioral deficits associated with schizophrenia.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Haigh SM,Eack SM,Keller T,Minshew NJ,Behrmann Mdoi
10.1016/j.neuropsychologia.2019.107233subject
Has Abstractpub_date
2019-12-01 00:00:00pages
107233eissn
0028-3932issn
1873-3514pii
S0028-3932(19)30277-5journal_volume
135pub_type
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