Abstract:
:Brainstem and midbrain nuclei are closely linked to effective cognitive performance and autonomic function. In the present study, we aimed to investigate indices of successful and unsuccessful response inhibition paying particular attention to the interplay between locus coeruleus (LC), ventral tegmental area (VTA)/substantia nigra (SN) and, most importantly, peripheral markers. We aimed to get insight in the predictive value of neural and physiological signals in response inhibition. A total of 35 healthy controls were recruited from the local community and a typical task of behavioral response inhibition (Go/No-Go paradigm) was applied. We used high-resolution fMRI, advanced brainstem analyses and specifically corrected for respiratory signal and cardiac noise. Our main results characterize specific neural activation patterns during successful and unsuccessful response inhibition especially comprising the anterior cingulate as well as the medial and lateral prefrontal cortex. A significant activation of the dopaminergic nuclei (VTA/SN) was found during error processing, but not during response inhibition. Most remarkably, specific neural activation patterns (i.e., dorsal anterior cingulate cortex) as well as accompanying autonomic indices (i.e., skin conductance response (SCR)) were identified to hold predictive information on an individual's performance. In summary, the importance of the VTA/SN during error processing was shown. Furthermore, autonomic indices and specific neural activation patterns may contain valuable information to predict task performance.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Köhler S,Schumann A,de la Cruz F,Wagner G,Bär KJdoi
10.1016/j.neuropsychologia.2018.08.003subject
Has Abstractpub_date
2018-10-01 00:00:00pages
182-190eissn
0028-3932issn
1873-3514pii
S0028-3932(18)30450-0journal_volume
119pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::We propose a battery of simple clinical tests to assess the development of elementary visuo-spatial perception. We postulate that most of the tasks we selected rely on the visual dorsal stream, although the dual-stream theory (Milner & Goodale, 1995) discards the role of the dorsal stream for visual perception. In ord...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2012.11.015
更新日期:2013-01-01 00:00:00
abstract::This is a prospective neuropsychological study on face processing in Alzheimer's disease (AD). The aim was to assess the prevalence and the nature of face processing disorders in AD, and at investigating possible inter-test dissociations within the framework of currently used face processing models. A standardized fou...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/0028-3932(95)00009-r
更新日期:1995-06-01 00:00:00
abstract::This study used functional MRI and an artificial language training paradigm to explore sex differences in the processing of a new writing system and how sex determines the optimal neural resource recruitment for visual word learning. Results indicated that males and females achieved equal learning outcome, and their l...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.08.018
更新日期:2007-03-02 00:00:00
abstract::The study of the neuroanatomical correlates of category-specific semantic disorders has strongly supported the 'sensory/motor model of semantic knowledge,' which assumes that the cortical areas that have critically contributed to the development of various categories are also implicated in their semantic representatio...
journal_title:Neuropsychologia
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.neuropsychologia.2003.08.006
更新日期:2004-01-01 00:00:00
abstract::Visuomotor deficits in parietal patients suffering from Optic Ataxia (OA) have been so far studied during natural reaching movements. We aimed at understanding if these disorders are also present when more abstract visuomotor transformations are involved. A patient with unilateral OA was tested during both standard re...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.07.029
更新日期:2014-10-01 00:00:00
abstract::Obesity has been associated with impaired executive functions including working memory. Less explored is the influence of obesity on learning and memory. In the current study we assessed stimulus reward association learning, explicit learning and memory and working memory in healthy weight, overweight and obese indivi...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.10.004
更新日期:2014-12-01 00:00:00
abstract::Two underlying components of verbal fluency tasks have been identified as clustering (the ability to generate successive words within a sub-category) and switching (the ability to shift from one sub-category to another). Selective impairment of switching ability occurs in patients with frontostriatal pathology, whilst...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00217-2
更新日期:2002-01-01 00:00:00
abstract::Previous research on memory and schizophrenia has relied on a limited number of global memory measures instead of a comprehensive assessment of various memory components. In addition, little effort has been directed at examining memory functioning in patients with early-onset schizophrenia. Published research often la...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(99)00043-3
更新日期:1999-11-01 00:00:00
abstract::The personality trait of novelty seeking (NS) has been associated with the long variant of the dopamine D4 receptor (L-DRD4) VNTR polymorphism. This is the first study to examine the influence of L-DRD4 polymorphism on some of the cognitive (i.e. decision making) and emotional underpinnings of the NS phenotype. One hu...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.02.005
更新日期:2009-06-01 00:00:00
abstract::This fMRI study explored the functional neural organisation of seen speech in congenitally deaf native signers and hearing non-signers. Both groups showed extensive activation in perisylvian regions for speechreading words compared to viewing the model at rest. In contrast to earlier findings, activation in left middl...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2007.11.026
更新日期:2008-04-01 00:00:00
abstract::Patients with postchiasmatic visual field defects often show a contralesional bias towards the scotoma in line bisection or when indicating their visual subjective straight ahead (VSSA). Recent evidence suggests a retinotopic misrepresentation of visual space in patients with homonymous quadrantanopia (HQ). We therefo...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2010.06.035
更新日期:2010-09-01 00:00:00
abstract::In humans and great apes, both the planum temporale (PT-part of Wernicke's area) and the sylvian fissure (SF) in the left cerebral hemisphere have been consistently shown to be larger than the corresponding structures in the right hemisphere. The greater length of the SF in the left hemisphere is commonly thought to b...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(02)00288-9
更新日期:2003-01-01 00:00:00
abstract::Reward-predicting stimuli can induce maladaptive behavior by provoking action tendencies that conflict with long-term goals. Earlier, we showed that when human participants were permitted to respond for a reward in the presence of a task-irrelevant, reward-predicting stimulus (i.e. goCS+ trials), the CS+ provoked an a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.01.016
更新日期:2015-02-01 00:00:00
abstract::There have been a number of reports of preserved face imagery in prosopagnosia. We put this issue to experimental test by comparing the performance of MJH, a 34-year-old prosopagnosic since the age of 5, to controls on tasks where the participants had to judge faces of current celebrities, either in terms of overall s...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(02)00176-8
更新日期:2003-01-01 00:00:00
abstract::Slow wave ERPs were recorded from 28 young adults as they generated plans for various difficulty levels of a fixed-foreperiod version of the Tower of London task. The resulting waveform included three segments: (1) a left-lateralized negative early-interval wave, which was frontally maximal but not sensitive to diffic...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.02.025
更新日期:2011-04-01 00:00:00
abstract::The processing of hierarchical stimuli was examined in patients with lesions in the temporal-parietal junction. In separate blocks of trials, subjects were instructed to identify the letter at the local or the global level of a hierarchical stimulus. Consistent with previous findings, reaction times for controls were ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(89)90052-3
更新日期:1989-01-01 00:00:00
abstract::The selective attention to facial emotion and identity was investigated in 12 patients with schizophrenia and 12 healthy participants. Both patients and controls were required to perform two classification tasks (according either to identity or emotion). Two separate values for identity (person A/person B) and for emo...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00114-2
更新日期:2002-01-01 00:00:00
abstract::Measures of left-right asymmetry in resting brain activity were derived from spectral estimates of electroencephalogram (EEG) alpha-band power density in 13 homologous scalp electrode pairs from 81 right-handed individuals (43 F) on two occasions separated by 6 weeks. At a third, later session, these individuals compl...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(00)00076-2
更新日期:2000-01-01 00:00:00
abstract::Anthrozoological neuroscience, which we propose as the use of neuroscience techniques to study human-animal interaction, may help to elucidate mechanisms underlying the associated psychological, physiological, and other purported health effects. This preliminary study investigates the neural response to animal photogr...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2016.03.018
更新日期:2016-05-01 00:00:00
abstract::Learning about visual object categories causes changes in the way we perceive those objects. One likely mechanism by which this occurs is the application of attention to potentially relevant objects. Here we test the hypothesis that category membership influences the allocation of attention, allowing attention to be a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.07.025
更新日期:2017-09-01 00:00:00
abstract::The investigation employed monorhinic (single nostril) olfactory testing to decide whether patients with unilateral anterior temporal lobe resection (N = 16) and patients with unoperated temporal lobe epilepsy (N = 18) have impaired ability to detect, remember, and identify odors. A shape memory task accompanied the o...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(86)90099-0
更新日期:1986-01-01 00:00:00
abstract::Children with closed head injuries often experience significant and persistent disruptions in their social and behavioral functioning. Studies with adults sustaining a traumatic brain injury (TBI) indicate deficits in emotion recognition and suggest that these difficulties may underlie some of the social deficits. The...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2010.05.029
更新日期:2010-08-01 00:00:00
abstract::This study investigated the types of verbal errors produced by aphasic patients following phonemic and semantic cueing. Twenty-eight aphasic patients--10 Broca's, 10 Wernicke's and 8 conduction aphasics--served as subjects. Semantic and phonemic cues were administered on object and action confrontation-naming tasks. W...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(91)90078-m
更新日期:1991-01-01 00:00:00
abstract::Research of the neurobiological bases of learning and memory suggest that these processes are not unitary in nature, but rather that relatively independent neural systems appear to mediate different types of memory. Neurobiological studies, for instance, have identified separable cognitive or "declarative" and stimulu...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/s0028-3932(02)00157-4
更新日期:2003-01-01 00:00:00
abstract::People with schizophrenia (PSZ) often fail to pursue rewarding activities despite largely intact in-the-moment hedonic experiences. Deficits in effort-based decision making in PSZ may be related to enhanced effects of cost or reduced reward, i.e., through the amplification of negative prediction errors or by dampened ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.04.031
更新日期:2019-02-04 00:00:00
abstract::Unilateral hearing loss (UHL) generates a disruption of binaural hearing mechanisms, which impairs sound localization and speech understanding in noisy environments. We conducted an original study using fMRI and psychoacoustic assessments to investigate the relationships between the extent of cortical reorganization a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107683
更新日期:2020-12-01 00:00:00
abstract::Rasmussen and Milner [N.Y.Acad. Sci. Vol. 299, pp. 355-379, 1977] published data on late-lesioned (after age 6) epileptic patients who had suffered left hemisphere lesions. They estimated that left hemisphere dominance occurred in 96% of dextrals and 70% of sinistrals. These figures have been regarded as valid estimat...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(95)00042-9
更新日期:1995-12-01 00:00:00
abstract::Studies of Parkinson's disease (PD) have shown impaired temporal ordering but interpretation may be confounded by task requirements and the effects of medication. We examined item recognition and recency discrimination in PD in relation to treatment and performance on other tests. Patients showed increased response la...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(93)90149-t
更新日期:1993-09-01 00:00:00
abstract::Multitasking behavior is associated with well-known performance costs, but the question of why individuals falter when attempting to manage multiple streams of information remains difficult to answer. One reason for this difficulty may be that multitasking costs are often characterized by isolating component processes...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2019.107149
更新日期:2019-09-01 00:00:00
abstract::A growing body of literature shows that the emotional content of verbal material affects reading, wherein emotional words are given processing priority compared to neutral words. Human emotions can be conceptualised within a two-dimensional model comprised of emotional valence and arousal (intensity). These variables ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.01.002
更新日期:2014-04-01 00:00:00