Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France.

abstract：:The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological pH and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gordon RC,Regamey C,Kirby WM

更新日期：1972-09-01 00:00:00

abstract：:Hematogenous Candida meningoencephalitis (HCME) is a serious infection in premature neonates. Anidulafungin is an echinocandin antifungal agent with potent activity against Candida spp., but its efficacy and optimal regimens for human neonates with HCME are not known. A well-validated rabbit model of HCME was used to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Warn PA,Livermore J,Howard S,Felton TW,Sharp A,Gregson L,Goodwin J,Petraitiene R,Petraitis V,Cohen-Wolkowiez M,Walsh TJ,Benjamin DK Jr,Hope WW

更新日期：2012-02-01 00:00:00

abstract：:A penicillin beta-lactamase (PCase) was extracted from Pseudomonas aeruginosa Rms139(+) and purified by means of column chromatography. The isoelectric point of Rms139 PCase was 5.7 and its molecular weight was 22,500 +/- 1,000. The optimal pH for the hydrolysis of benzylpenicillin was 7.0 to 7.5 and the optimal tempe...

journal_title：Antimicrobial agents and chemotherapy

authors： Sawada Y,Yaginuma S,Tai M,Iyobe S,Mitsuhashi S

更新日期：1976-01-01 00:00:00

abstract：:Using a new rabbit model of methicillin-susceptible Staphylococcus aureus knee prosthesis infection, we compared the efficacies of sparfloxacin (50 mg/kg of body weight subcutaneously, twice a day) and pefloxacin (50 mg/kg subcutaneously, twice a day). A partial knee replacement was performed with a silicone implant f...

journal_title：Antimicrobial agents and chemotherapy

authors： Crémieux AC,Mghir AS,Bleton R,Manteau M,Belmatoug N,Massias L,Garry L,Sales N,Mazière B,Carbon C

更新日期：1996-09-01 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:The physiological factors that contribute to Mycobacterium abscessus lung infections remain unclear. We determined whether antibiotic treatment targeting a major cystic fibrosis pathogen (i.e., Pseudomonas aeruginosa) could provide the ideal conditions for the establishment of M. abscessus infection. Our data showed t...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Sevilla G,Crabbé A,García-Coca M,Aguilera-Correa JJ,Esteban J,Pérez-Jorge C

更新日期：2019-10-22 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson JM,Prati F,Bethel CR,Bonomo RA

更新日期：2007-04-01 00:00:00

abstract：:Echinocandins are important in the prevention and treatment of invasive candidiasis but limited by current dosing regimens that include daily intravenous administration. The novel echinocandin CD101 has a prolonged half-life of approximately 130 h in humans, making it possible to design once-weekly dosing strategies. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,VanScoy B,Ambrose PG,Andes DR

更新日期：2018-01-25 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupont M,James CE,Chevalier J,Pagès JM

更新日期：2007-09-01 00:00:00

abstract：:The activities of mecillinam and ampicillin, alone and in combination, were evaluated in mice infected with the LT-2 strain of Salmonella typhimurium. The minimal inhibitory concentrations of mecillinam and ampicillin for this strain were, respectively, 6.2 and 0.4 microgram/ml of culture medium. In vitro synergy was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler T,Shuster CW,Dixon P

更新日期：1981-02-01 00:00:00

abstract：:Carbapenemases are among the newest resistance mechanisms to emerge in some gram-negative bacteria. We describe bacteremia in a critically ill liver transplant recipient infected with KPC-2-producing Enterobacter cloacae and Pseudomonas putida. Although this enzyme has been previously described in Enterobacter spp., t...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett JW,Herrera ML,Lewis JS 2nd,Wickes BW,Jorgensen JH

更新日期：2009-01-01 00:00:00

abstract：:Chronic airway infection and inflammation contribute to the progressive loss of lung function and shortened survival of patients with cystic fibrosis (CF). Rhesus theta defensin-1 (RTD-1) is a macrocyclic host defense peptide with antimicrobial and immunomodulatory activities. Combined with favorable preclinical safet...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Jayne JG,Sun M,Kimura E,Meinert J,Wang JC,Schaal JB,Tran D,Rao AP,Akbari O,Selsted ME,Beringer PM

更新日期：2017-07-25 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00

abstract：:Expression of high-level beta-lactam resistance is known to be thermosensitive in many methicillin-resistant Staphylococcus aureus (MRSA) strains, including strain COL, in which the high methicillin MIC for cultures grown at 37 degrees C (800 microg/ml) was reduced to 12 microg/ml at 42 degrees C. COL grew faster at 4...

journal_title：Antimicrobial agents and chemotherapy

authors： Sieradzki K,Chung M,Tomasz A

更新日期：2008-02-01 00:00:00

abstract：:Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Ca...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachmann SP,VandeWalle K,Ramage G,Patterson TF,Wickes BL,Graybill JR,López-Ribot JL

更新日期：2002-11-01 00:00:00

abstract：:The antibiotic tolerances of bacterial persisters have been attributed to transient dormancy. While persisters have been observed to be growth inhibited prior to antibiotic exposure, we sought to determine whether such a trait was essential to the phenotype. Furthermore, we sought to provide direct experimental eviden...

journal_title：Antimicrobial agents and chemotherapy

authors： Orman MA,Brynildsen MP

更新日期：2013-07-01 00:00:00

abstract：:The pharmacokinetics of the antifungal pradimicin derivative BMS 181184 in plasma of normal, catheterized rabbits were characterized after single and multiple daily intravenous administrations of dosages of 10, 25, 50, or 150 mg/kg of body weight, and drug levels in tissues were assessed after multiple dosing. Concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Sein T,Petraitis V,Petraitiene R,Callender D,Gonzalez CE,Giri N,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-10-01 00:00:00

abstract：:As drug resistance continues to grow, treatment strategies that turn resistance into a disadvantage for the organism will be increasingly relied upon to treat infections and to lower the rate of multidrug resistance. The majority of work in this area has investigated how resistance evolution toward a single antibiotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez de Evgrafov MC,Faza M,Asimakopoulos K,Sommer MOA

更新日期：2020-12-16 00:00:00

abstract：:The efficacy of an itraconazole-cyclodextrin solution against Aspergillus fumigatus was assessed in an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis and compared with that of amphotericin B. Oral itraconazole solution at dosages of 20 and 40 mg/kg/day improved survival as compared wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Patterson TF,Fothergill AW,Rinaldi MG

更新日期：1993-11-01 00:00:00

abstract：:In order to probe the structure and function of the mycobacterial catalase-peroxidase enzyme (KatG), we employed a genetic approach using dominant-negative analysis of katG merodiploids. Transformation of Mycobacterium bovis BCG with various katG point mutants (expressed from low-copy-number plasmids) resulted in redu...

journal_title：Antimicrobial agents and chemotherapy

authors： DeVito JA,Morris S

更新日期：2003-01-01 00:00:00

abstract：:Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlat...

journal_title：Antimicrobial agents and chemotherapy

authors： Karema C,Imwong M,Fanello CI,Stepniewska K,Uwimana A,Nakeesathit S,Dondorp A,Day NP,White NJ

更新日期：2010-01-01 00:00:00

abstract：:Porphyromonas gingivalis is a bacterial pathogen associated with chronic periodontitis that results in destruction of the tooth's supporting tissues. The major virulence determinants of P. gingivalis are its cell surface Arg- and Lys-specific cysteine proteinases, RgpA/B and Kgp. Lactoferrin (LF), an 80-kDa iron-bindi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dashper SG,Pan Y,Veith PD,Chen YY,Toh EC,Liu SW,Cross KJ,Reynolds EC

更新日期：2012-03-01 00:00:00

abstract：:Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy volunteers showed that once...

journal_title：Antimicrobial agents and chemotherapy

authors： Dietze R,Teixeira L,Rocha LM,Palaci M,Johnson JL,Wells C,Rose L,Eisenach K,Ellner JJ

更新日期：2001-07-01 00:00:00

abstract：:Enterococci are intrinsically resistant to low levels of aminoglycosides. We previously selected in vitro and in vivo Enterococcus faecalis with intermediate-level resistance to gentamicin that did not abolish synergism with a cell-wall-active agent (E. Aslangul et al., Antimicrob. Agents Chemother. 49:4144-4148, 2005...

journal_title：Antimicrobial agents and chemotherapy

authors： Aslangul E,Massias L,Meulemans A,Chau F,Andremont A,Courvalin P,Fantin B,Ruimy R

更新日期：2006-11-01 00:00:00

abstract：:Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor age...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae SH,Kwon MJ,Park JB,Kim D,Kim DH,Kang JS,Kim CG,Oh E,Bae SK

更新日期：2014-09-01 00:00:00

abstract：:Ribonucleic acid (RNA) synthesis in the sorbitol-dependent, fragile yeast mutant VY1160 (Venkov et al., 1974) is rapidly inhibited by rifampin. The growth of the mutant cells and protein synthesis are more slowly affected by the antibiotic, apparently as secondary phenomena. Lower doses of rifampin (50 to 100 mug/ml) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venkov PV,Milchev GI,Hadjiolov AA

更新日期：1975-12-01 00:00:00

abstract：:Serious Enterococcus faecalis infections usually require combination therapy to achieve a bactericidal effect. In orthopedic infections, the prognosis of enterococcal etiology is considered poor, and the use of aminoglycosides is questioned. The ampicillin-ceftriaxone combination has recently been accepted as alternat...

journal_title：Antimicrobial agents and chemotherapy

authors： Euba G,Lora-Tamayo J,Murillo O,Pedrero S,Cabo J,Verdaguer R,Ariza J

更新日期：2009-10-01 00:00:00

abstract：:Most antibiotics are known to be incapable of killing nongrowing or slowly growing bacteria with few exceptions. Bacterial cell division is inhibited during the postantibiotic phase (PA phase) after short exposure to antibiotics. Only scarce and conflicting data are available concerning the ability of antibiotics to k...

journal_title：Antimicrobial agents and chemotherapy

authors： Odenholt I,Löwdin E,Cars O

更新日期：1997-11-01 00:00:00

abstract：:Vancomycin has been associated with acute kidney injury in preclinical and clinical settings; however, the precise exposure profiles associated with vancomycin-induced acute kidney injury have not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kid...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Donnell JN,Rhodes NJ,Lodise TP,Prozialeck WC,Miglis CM,Joshi MD,Venkatesan N,Pais G,Cluff C,Lamar PC,Briyal S,Day JZ,Gulati A,Scheetz MH

更新日期：2017-10-24 00:00:00