Abstract:
:A quantitative analysis has cast doubt over the limited advantages provided by particles for nose-to-brain (NTB) drug delivery. Thus, it is imperative to identify the role of nanovehicles in NTB drug delivery. If nanocarriers are used merely as an option to improve various properties of the drugs or the formulations, it is difficult for them to outperform conventional formulations, such as solutions or gels. However, nanovehicles bring about special features, such as maintenance of the solubilized state of drugs, sustained or delayed release, and enhanced penetration because of surface modifications, all of which lead to enhanced NTB delivery efficiency.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Feng Y,He H,Li F,Lu Y,Qi J,Wu Wdoi
10.1016/j.drudis.2018.01.005subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1079-1088issue
5eissn
1359-6446issn
1878-5832pii
S1359-6446(17)30329-Xjournal_volume
23pub_type
杂志文章,评审abstract::A more complete understanding of the mechanisms that drive autoimmune diseases has begun to be translated into therapeutic options with significant clinical consequences. A clear example of this is the introduction of biological therapies, which have provided new therapeutic avenues, as well as validated the mediators...
journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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