Abstract:
:A reduction in intraocular pressure (IOP) is the only recognized therapy for glaucoma. Hence, drugs exhibiting ocular hypotensive effects are important targets for antiglaucomatous drug development. IOP is determined by the equilibrium of aqueous humor production and outflow through either the trabecular meshwork or the uveoscleral outflow pathway. There is increasing evidence that nitric oxide (NO) has a major role in the regulation of IOP by directly acting on the trabecular meshwork and thereby lowering IOP. Taking advantage of this mechanism, newly designed NO-donating drugs combine the IOP-lowering effect of known substances with the trabecular meshwork outflow-increasing effect of NO. Here, we review the molecular mechanism of this new entity of IOP-lowering drugs.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Garhöfer G,Schmetterer Ldoi
10.1016/j.drudis.2019.05.033subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1614-1620issue
8eissn
1359-6446issn
1878-5832pii
S1359-6446(18)30388-Xjournal_volume
24pub_type
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