Supramolecular devices to improve the treatment of brain diseases.

Abstract:

:The blood-brain barrier (BBB) hinders the accumulation of active compounds in the central nervous system, thus decreasing their therapeutic effectiveness. To overcome this obstacle, interesting supramolecular nanodevices are herein considered. These systems have many advantages over the conventional formulations, such as having structures made up of biocompatible and biodegradable materials, the possibility of bypassing the BBB in a non-invasive manner (without structural modifications) and the possibility of being structurally modified to modulate the biopharmaceutical properties of the encapsulated compounds. Polymolecular (liposomes, niosomes, nanogels) and oligomolecular (cyclodextrins) devices have potential clinical applications in brain drug delivery, being capable of active targeting that can concentrate bioactives in the brain.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Paolino D,Cosco D,Molinaro R,Celia C,Fresta M

doi

10.1016/j.drudis.2011.02.006

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

311-24

issue

7-8

eissn

1359-6446

issn

1878-5832

pii

S1359-6446(11)00038-9

journal_volume

16

pub_type

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