Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder.

abstract：:Identifying the right target for drug development is a critical bottleneck in the pharmaceutical and biotech industries. The genomics revolution has shifted the problem from a scarcity of targets to a surplus of putative drug targets. As the validity of a target cannot be simply inferred from correlative data, the key...

journal_title：Drug discovery today

authors： Ilag LL,Ng JH,Beste G,Henning SW

更新日期：2002-09-15 00:00:00

abstract：:The proces of piecemeal microautophagy of the nucleus describes the way in which autophagy occurs in the nucleus, a realm of the cell once considered to be off limits for autophagy. ...

journal_title：Drug discovery today

authors： Sutherland S

更新日期：2003-03-15 00:00:00

abstract：:Intravitreal injection is one of the major administration routes for the treatment of posterior ocular diseases. Intravitreal therapeutics usually suffer from unsatisfactory efficacy owing to fast clearance from the vitreous humour and insufficient distribution into the retina. Engineered nanoparticles have been appli...

journal_title：Drug discovery today

authors： Huang X,Chau Y

更新日期：2019-08-01 00:00:00

abstract：:Antibodies (Abs) are regarded as a newly emerging form of therapeutics that can provide passive protection against influenza. Although the application of genomics in clinics has increased dramatically, the number of therapeutics available for the treatment of many diseases remains insufficient. To translate genomics i...

journal_title：Drug discovery today

authors： Yang HT,Yang H,Chiang JH,Wang SJ

更新日期：2016-10-01 00:00:00

abstract：:Over the past decade, together with the improvement of traditional cancer treatments, conveniently designed (with respect to their size, shape, main material, and coating) and specifically targeted nanovehicles have been developed. Nano-sized carriers can be functionalized to recognize key structures expressed in canc...

journal_title：Drug discovery today

authors： Saenz del Burgo L,Pedraz JL,Orive G

更新日期：2014-10-01 00:00:00

abstract：:Novel starting points for drug discovery projects are generally found either by screening large collections of compounds or smaller more-focused libraries. Ideally, hundreds or even thousands of actives are initially found, and these need to be reduced to a handful of promising lead series. In several sequential steps...

journal_title：Drug discovery today

authors： Schnecke V,Boström J

更新日期：2006-01-01 00:00:00

abstract：:Since being introduced to the field of drug discovery at Zeneca Pharmaceuticals in 1991, it has become apparent to me that a blizzard of revolutionary novel approaches has swept through the pharmaceutical industry. Now, the discovery process has become completely transformed and the race to develop commercially succes...

journal_title：Drug discovery today

authors： Tranter D

更新日期：1999-01-01 00:00:00

abstract：:A rapid expansion in precision medicine founded on the potential for durable clinical benefit through matching a drug to a predictive marker used to select patients has driven the development of targeted drugs with accompanied companion diagnostics for patient selection. Oncology has been at the forefront, with the im...

journal_title：Drug discovery today

authors： Hollingsworth SJ

更新日期：2015-12-01 00:00:00

abstract：:Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevan...

journal_title：Drug discovery today

authors： Westwell A

更新日期：2001-02-01 00:00:00

abstract：:A reduction in intraocular pressure (IOP) is the only recognized therapy for glaucoma. Hence, drugs exhibiting ocular hypotensive effects are important targets for antiglaucomatous drug development. IOP is determined by the equilibrium of aqueous humor production and outflow through either the trabecular meshwork or t...

journal_title：Drug discovery today

authors： Garhöfer G,Schmetterer L

更新日期：2019-08-01 00:00:00

abstract：:Benford's law states that the distribution of the first digit of many data sets is not uniform. The first digit of any random number will be 1 almost 30% of the time, and larger digits occur as the first digit with lower and lower frequency, to the point where 9 occurs as a first digit only 5% of the time. Here, we de...

journal_title：Drug discovery today

authors： Orita M,Moritomo A,Niimi T,Ohno K

更新日期：2010-05-01 00:00:00

abstract：:Stimulation of bone regeneration using growth factors is a promising approach for musculoskeletal regenerative engineering. However, common limitations with protein growth factors, such as high manufacturing costs, protein instability, contamination issues, and unwanted immunogenic responses of the host reduce potenti...

journal_title：Drug discovery today

authors： Laurencin CT,Ashe KM,Henry N,Kan HM,Lo KW

更新日期：2014-06-01 00:00:00

abstract：:Acute and chronic cough represent one of the most common symptoms of medical importance but effective pharmacotherapy is, to all intents and purposes, absent. Numerous initiatives targeting the recently discovered tussive pathways are in progress. Here, we review the current antitussive armamentarium and provide an up...

journal_title：Drug discovery today

authors： Morjaria JB,Dickinson RS,Morice AH

更新日期：2013-04-01 00:00:00

abstract：:Data, which help inform various stages of drug product development, are increasingly being collected using newer, more novel platforms, such as mobile applications, and analysed computationally as much larger 'Big Data' data sets, revealing patterns relating to human behaviour and interactions. Medicine acceptability ...

journal_title：Drug discovery today

authors： Desai N,Edwards AJ,Ernest TB,Tuleu C,Orlu M

更新日期：2020-12-24 00:00:00

abstract：:We have broken old surviving dogmas and concepts used in computational chemistry and created an efficient in silico ADME-T pharmacological properties modeling and prediction toolbox for any xenobiotic. With the help of an innovative and pragmatic approach combining various in silico techniques, like molecular modeling...

journal_title：Drug discovery today

authors： Jacob A,Pratuangdejkul J,Buffet S,Launay JM,Manivet P

更新日期：2009-04-01 00:00:00

abstract：:Atomic force microscopy is being used ever more widely in biological imaging, because of its unique ability to provide structural information at the single molecule level and under near-physiological conditions. Detailed topographic images of potential drug targets, such as proteins and DNA, have been produced, and th...

journal_title：Drug discovery today

authors： Edwardson JM,Henderson RM

更新日期：2004-01-15 00:00:00

abstract：:Conventional mitogen-activated protein kinase (MAPK) family members are among the most sought-after oncogenic effectors for the development of novel human cancer treatment strategies. MEK5/ERK5 has been the less-studied MAPK subfamily, despite its increasingly demonstrated relevance in the growth, survival, and differ...

journal_title：Drug discovery today

authors： Simões AE,Rodrigues CM,Borralho PM

更新日期：2016-10-01 00:00:00

abstract：:The lack of structural information on hepatitis C virus (HCV) surface proteins has so far hampered the development of effective vaccines. Recently, two crystallographic structures have described the core portion (E2c) of E2 surface glycoprotein, the primary mediator of HCV entry. Despite the importance of these studie...

journal_title：Drug discovery today

authors： Castelli M,Clementi N,Sautto GA,Pfaff J,Kahle KM,Barnes T,Doranz BJ,Dal Peraro M,Clementi M,Burioni R,Mancini N

更新日期：2014-12-01 00:00:00

abstract：:Following the introduction of antibiotic therapy and widespread inoculations, cardiovascular diseases have leapt ahead of infectious diseases in terms of prevalence in much of the developed and developing world. Herein, we assess FDA-approved drugs for the treatment of cardiovascular diseases. The drug development ent...

journal_title：Drug discovery today

authors： Kinch MS,Surovtseva Y,Hoyer D

更新日期：2016-01-01 00:00:00

abstract：:This memorandum is addressed to members of regulatory agencies, as well as managers of pharmaceutical companies. Pharmacokineticists and toxicologists may consider this proposal, weigh its merits, and provide input for implementation. Experience from academic research and ADME experiments during drug development has p...

journal_title：Drug discovery today

authors： Stumpf WE

更新日期：2007-08-01 00:00:00

abstract：:One of the world's fastest growing cities, Atlanta is the business center of the Southeast U.S. and is rapidly becoming a leader for biotechnology innovation. ...

journal_title：Drug discovery today

authors： Allen CR

更新日期：2005-02-15 00:00:00

abstract：:The sustained growth of biotechnology in North Carolina has made the state a worldwide leader in biotechnology. ...

journal_title：Drug discovery today

authors： Hartl B

更新日期：2005-11-15 00:00:00

abstract：:Allosteric modulators have the potential to fine-tune protein functional activity. Therefore, the targeting of allosteric sites, as a strategy in drug design, is gaining increasing attention. Currently, it is not trivial to find and characterize new allosteric sites by experimental approaches. Alternatively, computati...

journal_title：Drug discovery today

authors： Lu S,Huang W,Zhang J

更新日期：2014-10-01 00:00:00

abstract：:Polymer-drug conjugates (PDC) have exhibited clinical and commercial success in the field of drug delivery. A polymeric backbone, linker, targeting moiety, and drug constitute the building blocks of PDCs. Current attention is focusing on natural polymeric carriers, in particular the concept of graft copolymers, such a...

journal_title：Drug discovery today

authors： Thakor P,Bhavana V,Sharma R,Srivastava S,Singh SB,Mehra NK

更新日期：2020-09-01 00:00:00

abstract：:Effective cancer treatment remains a significant challenge in human healthcare. Although many different types of cancer therapy have been tested, scientists have now concluded that combinations of drugs, or drugs plus gene therapy, can target multiple pathways to fight cancer. Nanovehicles can increase drug uptake ins...

journal_title：Drug discovery today

authors： Zeinali M,Abbaspour-Ravasjani S,Ghorbani M,Babazadeh A,Soltanfam T,Santos AC,Hamishehkar H,Hamblin MR

更新日期：2020-08-01 00:00:00

abstract：:This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have ...

journal_title：Drug discovery today

authors： van Rijt SH,Sadler PJ

更新日期：2009-12-01 00:00:00

abstract：:Covalent allosteric modulators possess the pharmacological advantages (high potency, extended duration of action and low drug resistance) of covalent ligands and the additional benefit of the higher specificity and lower toxicity of allosteric modulators. This approach is gaining increasing recognition as a valuable t...

journal_title：Drug discovery today

authors： Lu S,Zhang J

更新日期：2017-02-01 00:00:00

abstract：:The function of many key proteins and transcription factors involved in cell growth can be regulated by their cellular localization. Such proteins include the tumor suppressor p53 and the nuclear factor kappaB. Although the idea of trapping such proteins in either the nucleus or cytoplasm has been introduced as a pote...

journal_title：Drug discovery today

authors： Kau TR,Silver PA

更新日期：2003-01-15 00:00:00

abstract：:Following multiple warnings from governments and health organisations, there has been renewed investment, led by the public sector, in the discovery of novel antimicrobials to meet the challenge of rising levels of drug-resistant infection, particularly in the case of resistance to antibiotics. Initiatives have also b...

journal_title：Drug discovery today

authors： Dougan G,Dowson C,Overington J,Next Generation Antibiotic Discovery Symposium Participants.

更新日期：2019-02-01 00:00:00

abstract：:Although the oral route is the most popular and acceptable way of drug administration owing to good patient compliance and safety, oral drug delivery is faced with continuous challenges regarding poorly soluble, poorly permeable or gastrointestinally unstable drugs such as proteins and polypeptides. The overall bioava...

journal_title：Drug discovery today

authors： Zhang X,Wu W

更新日期：2014-07-01 00:00:00