Abstract:
:Polymer-drug conjugates (PDC) have exhibited clinical and commercial success in the field of drug delivery. A polymeric backbone, linker, targeting moiety, and drug constitute the building blocks of PDCs. Current attention is focusing on natural polymeric carriers, in particular the concept of graft copolymers, such as a combination of polymers and polysaccharides, to explore dual benefits such as combined vehicles and targeting moieties. Polymer heterogeneity, synthesis of PDCs, broad molecular weight distribution, conjugate variability, immunogenicity of polymers, safety, stability, and stringent regulatory approval are the major obstacles to the successful transition of PDCs to the clinic. In this review, we discuss natural and synthetic PDCs combined with computational modeling for diverse pharmaceutical and biomedical applications.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Thakor P,Bhavana V,Sharma R,Srivastava S,Singh SB,Mehra NKdoi
10.1016/j.drudis.2020.06.028subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1718-1726issue
9eissn
1359-6446issn
1878-5832pii
S1359-6446(20)30256-7journal_volume
25pub_type
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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