Novel antitumour molecules.

abstract：:In therapeutic areas aimed at developing an orally administered drug, the pharmacokinetic profile of a drug candidate after oral administration in vivo is pivotal in evaluating its success. This can be done by monitoring the plasma concentration versus time after dosing and calculating the area under the curve (AUC). ...

journal_title：Drug discovery today

authors： Cox KA,Dunn-Meynell K,Korfmacher WA,Broske L,Nomeir AA,Lin CC,Cayen MN,Barr WH

更新日期：1999-05-01 00:00:00

abstract：:In developed countries that protect core aspects of the fundamental human right to the highest attainable standard of health, how does that right intersect with intellectual property rights? Here, the human rights implication of providing access to all cancer drugs recommended by experts in a developed country is cons...

journal_title：Drug discovery today

authors： Khachigian LM

更新日期：2020-07-01 00:00:00

abstract：:The completion of the human genome sequencing project has provided a flood of new information that is likely to change the way scientists approach the study of complex biological systems. A major challenge lies in translating this information into new and better ways to treat human disease. The multidisciplinary scien...

journal_title：Drug discovery today

authors： Jeffery DA,Bogyo M

更新日期：2004-01-15 00:00:00

abstract：:Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of several important endogenous fatty acid amides (FAAs), including anandamide, oleoylethanolamide and palmitoylethanolamide. Because specific FAAs interact with cannabinoid and vanilloid receptors, they are often referred to as 'endocannabinoids' or ...

journal_title：Drug discovery today

authors： Pillarisetti S,Alexander CW,Khanna I

更新日期：2009-12-01 00:00:00

abstract：:Drug discovery and development is a highly complex process requiring the generation of very large amounts of data and information. Currently this is a largely unmet informatics challenge. The current approaches to building information and knowledge from large amounts of data has been addressed in cases where the types...

journal_title：Drug discovery today

authors： Claus BL,Underwood DJ

更新日期：2002-09-15 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive and lethal human malignancies. Drug therapies and radiotherapy are used for treatment as adjuvants to surgery, but outcomes remain disappointing. Advances in tissue engineering suggest that 3D cultures can reflect the in vivo tumor microenvironment and can guarantee a ph...

journal_title：Drug discovery today

authors： Totti S,Vernardis SI,Meira L,Pérez-Mancera PA,Costello E,Greenhalf W,Palmer D,Neoptolemos J,Mantalaris A,Velliou EG

更新日期：2017-04-01 00:00:00

abstract：:The transition from slow, manual, low-throughput screening to industrialized robotic ultra-high throughput screening (uHTS) in the past few years has made it possible to screen hundreds of thousands of chemical entities against a biological target in a short time-frame. The need to minimize the cost of screening has b...

journal_title：Drug discovery today

authors： Wölcke J,Ullmann D

更新日期：2001-06-01 00:00:00

abstract：:It is widely accepted that placental ischemia is central in the evolution of hypertension in pregnancy. Many studies and reviews have targeted placental ischemia to explain mechanisms for initiating pregnancy hypertension. The placenta is rich in blood vessels, which are the basis for developing placental ischemia. Ho...

journal_title：Drug discovery today

authors： Gao Q,Tang J,Li N,Liu B,Zhang M,Sun M,Xu Z

更新日期：2018-02-01 00:00:00

abstract：:In drug discovery and development (DDD), the efficacy, safety and cost of new chemical entities are the main concerns of the pharmaceutical industry. Continuously updated and stricter recommendations imposed by regulatory authorities result in greater challenges being faced by the industry. Reliable high-throughput te...

journal_title：Drug discovery today

authors： Khan SR,Baghdasarian A,Fahlman RP,Michail K,Siraki AG

更新日期：2014-05-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Drug discovery today

authors： Satcher R,Evans-Storms RB

更新日期：2012-06-01 00:00:00

abstract：:Polymer-drug conjugates (PDC) have exhibited clinical and commercial success in the field of drug delivery. A polymeric backbone, linker, targeting moiety, and drug constitute the building blocks of PDCs. Current attention is focusing on natural polymeric carriers, in particular the concept of graft copolymers, such a...

journal_title：Drug discovery today

authors： Thakor P,Bhavana V,Sharma R,Srivastava S,Singh SB,Mehra NK

更新日期：2020-09-01 00:00:00

abstract：:Tuberculosis drug discovery has shifted in recent years from a primarily target-based approach to one that uses phenotypic high-throughput screens. As examples of this, through our EU-funded FP7 collaborations, New Medicines for Tuberculosis was target-based and our more-recent More Medicines for Tuberculosis project ...

journal_title：Drug discovery today

authors： Mikušová K,Ekins S

更新日期：2017-03-01 00:00:00

abstract：:Osteoarthritis (OA), the most common and disabling form of arthritic disease, is characterized by a slow and progressive degeneration of articular cartilage. Its etiology is multifactorial and includes genetic predisposition, obesity and aging. In addition to the cartilage itself, OA also involves the surrounding tiss...

journal_title：Drug discovery today

authors： De Ceuninck F,Sabatini M,Pastoureau P

更新日期：2011-05-01 00:00:00

abstract：:In vitro human small intestine models play a crucial part in preclinical drug development. Although conventional 2D systems possess many advantages, such as facile accessibility and high-throughput capability, they can also provide misleading results due to their relatively poor recapitulation of in vivo physiology. S...

journal_title：Drug discovery today

authors： Yu J,Carrier RL,March JC,Griffith LG

更新日期：2014-10-01 00:00:00

abstract：:Atomic force microscopy is being used ever more widely in biological imaging, because of its unique ability to provide structural information at the single molecule level and under near-physiological conditions. Detailed topographic images of potential drug targets, such as proteins and DNA, have been produced, and th...

journal_title：Drug discovery today

authors： Edwardson JM,Henderson RM

更新日期：2004-01-15 00:00:00

abstract：:Outnumbering our own cells over ten times, gut microbes can even be considered an additional organ. Several studies have explored the association between microbiomes and antitumor drug response. It has been reported that the presence of specific bacteria might modulate cancer progression and the efficacy of anticancer...

journal_title：Drug discovery today

authors： Chen B,Du G,Guo J,Zhang Y

更新日期：2019-04-01 00:00:00

abstract：:There is currently a marketed drug for nearly every nuclear receptor for which the natural ligand has been identified. However, because of the complexity of signal transduction by this class of ligand-regulated transcription factors, few of these drugs have been optimized for pharmaceutical effectiveness. Over the pas...

journal_title：Drug discovery today

authors： Pearce KH,Iannone MA,Simmons CA,Gray JG

更新日期：2004-09-01 00:00:00

abstract：:14-3-3 proteins regulate intracellular signaling pathways, such as signal transduction, protein trafficking, cell cycle, and apoptosis. In addition to the ubiquitous roles of 14-3-3 isoforms, unique tissue-specific functions are also described for each isoform. Owing to their role in regulating cell cycle, protein tra...

journal_title：Drug discovery today

authors： Aghazadeh Y,Papadopoulos V

更新日期：2016-02-01 00:00:00

abstract：:The clinical advancement of HIV-1 attachment inhibitors was hindered initially by poor bioavailability. Attempts to identify improved candidates revealed that solubility and dissolution-rate-limited absorption are barriers to achieving adequate antiviral plasma levels. This was mitigated by forming nanosized drugs or ...

journal_title：Drug discovery today

authors： Timmins P,Brown J,Meanwell NA,Hanna GJ,Zhu L,Kadow JF

更新日期：2014-09-01 00:00:00

abstract：:Chemokines are proinflammatory mediators that primarily control leukocyte migration into selected tissues and upregulation of adhesion receptors. They also have a role in pathological conditions that require neovascularization and are implicated in the suppression of viral replication. By interaction with their respec...

journal_title：Drug discovery today

authors： Saunders J,Tarby CM

更新日期：1999-02-01 00:00:00

abstract：:Regenerative approaches are promising avenues to effectively cure diseases rather than merely treating symptoms, but are associated with concerns around proliferation in other organs. Given that targeted delivery holds the promise of delivering a drug precisely to its desired site of action, usually with the prospect ...

journal_title：Drug discovery today

authors： Valeur E,Knerr L,Ölwegård-Halvarsson M,Lemurell M

更新日期：2017-06-01 00:00:00

abstract：:The blood-brain barrier (BBB) hinders the accumulation of active compounds in the central nervous system, thus decreasing their therapeutic effectiveness. To overcome this obstacle, interesting supramolecular nanodevices are herein considered. These systems have many advantages over the conventional formulations, such...

journal_title：Drug discovery today

authors： Paolino D,Cosco D,Molinaro R,Celia C,Fresta M

更新日期：2011-04-01 00:00:00

abstract：:The emergence of induced pluripotent stem (iPS) cell technology has shifted gene correction therapy toward reality. Crucial issues are ensuring the safety of using iPS cell technology in patients and discovering how best to transfer genetically manipulated iPS cells back into patients. One key issue that has hindered ...

journal_title：Drug discovery today

authors： Nakayama M

更新日期：2010-03-01 00:00:00

abstract：:Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonopho...

journal_title：Drug discovery today

authors： Lavon I,Kost J

更新日期：2004-08-01 00:00:00

abstract：:Benford's law states that the distribution of the first digit of many data sets is not uniform. The first digit of any random number will be 1 almost 30% of the time, and larger digits occur as the first digit with lower and lower frequency, to the point where 9 occurs as a first digit only 5% of the time. Here, we de...

journal_title：Drug discovery today

authors： Orita M,Moritomo A,Niimi T,Ohno K

更新日期：2010-05-01 00:00:00

abstract：:The recent increase in pharmaceutical companies' efforts toward the treatment of obesity reflects recognition of the related health risks, the growth of knowledge about mechanisms that control energy balance, and the potential market for new compounds. The current patent literature gives a picture of the targets that ...

journal_title：Drug discovery today

authors： Jandacek RJ,Woods SC

更新日期：2004-10-15 00:00:00

abstract：:Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevan...

journal_title：Drug discovery today

authors： Barrett D,Barlocco D,Tranter D

更新日期：2001-03-01 00:00:00

abstract：:Poly(lactic-co-glycolic acid) (PLGA), a US Food and Drug Administration (FDA)-approved copolymer, has been exploited widely in the design of nanoparticles because it is biodegradable, biocompatible, protects the drug molecules from degradation, and aids in producing sustained and targeted delivery. However, certain co...

journal_title：Drug discovery today

authors： Pandita D,Kumar S,Lather V

更新日期：2015-01-01 00:00:00

abstract：:The pharmacological and adverse effect profiles of the two approved therapies for IPF make the development of new therapies challenging. Considering the similarity of the characteristics of drug candidates to Standard of Care is important in defining positioning and development strategies for this disease. ...

journal_title：Drug discovery today

authors： Cruwys S,Hein P,Humphries B,Black D

更新日期：2020-12-01 00:00:00

abstract：:3D bioprinting has emerged as the intersection between chemistry, biology and technology. Through its integration of cells, biocompatible materials and robotic-controlled dispensing systems, the process enables the production of structures that are biomimetic and functional, thus revolutionizing the concept of tissue ...

journal_title：Drug discovery today

authors： Parak A,Pradeep P,du Toit LC,Kumar P,Choonara YE,Pillay V

更新日期：2019-01-01 00:00:00