Abstract:
:Pancreatic cancer is one of the most aggressive and lethal human malignancies. Drug therapies and radiotherapy are used for treatment as adjuvants to surgery, but outcomes remain disappointing. Advances in tissue engineering suggest that 3D cultures can reflect the in vivo tumor microenvironment and can guarantee a physiological distribution of oxygen, nutrients, and drugs, making them promising low-cost tools for therapy development. Here, we review crucial structural and environmental elements that should be considered for an accurate design of an ex vivo platform for studies of pancreatic cancer. Furthermore, we propose environmental stress response biomarkers as platform readouts for the efficient control and further prediction of the pancreatic cancer response to the environmental and treatment input.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Totti S,Vernardis SI,Meira L,Pérez-Mancera PA,Costello E,Greenhalf W,Palmer D,Neoptolemos J,Mantalaris A,Velliou EGdoi
10.1016/j.drudis.2017.01.012subject
Has Abstractpub_date
2017-04-01 00:00:00pages
690-701issue
4eissn
1359-6446issn
1878-5832pii
S1359-6446(17)30041-7journal_volume
22pub_type
杂志文章,评审abstract::Identification and validation of viable targets is an important first step in drug discovery and new methods, and integrated approaches are continuously explored to improve the discovery rate and exploration of new drug targets. An in silico machine learning method, support vector machines, has been explored as a new ...
journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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更新日期:2016-04-01 00:00:00
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journal_title:Drug discovery today
pub_type: 杂志文章
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
pub_type: 杂志文章,评审
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