Translational dermatology in drug discovery: perspectives for integrating humanized xenograft models and experimental clinical studies.

Abstract:

:Application of humanized xenotransplantation disease models and experimental clinical studies in the context of translational research in drug discovery in dermatology is an opportunity to reduce failure due to lack of efficacy in clinical development stage.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Petersen TK,Sørensen P

doi

10.1016/j.drudis.2007.10.009

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

240-6

issue

5-6

eissn

1359-6446

issn

1878-5832

pii

S1359-6446(07)00423-0

journal_volume

13

pub_type

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    authors: Roche D,Gil D,Giraldo J

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    abstract::Since the Life Science Identifier (LSID) data identification and access standard made its official debut in late 2004, several organizations have begun to use LSIDs to simplify the methods used to uniquely name, reference and retrieve distributed data objects and concepts. In this review, the authors build on introduc...

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    authors: Martin S,Hohman MM,Liefeld T

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    abstract::Senescence forms a universal block to tumorigenesis which impacts on all hallmarks of cancer, making it an attractive target for drug discovery. Therefore a strategy must be devised to focus this broad potential into a manageable drug discovery programme. Several issues remain to be addressed including the lack of rob...

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    更新日期:2015-02-01 00:00:00

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    doi:10.1016/S1359-6446(05)03420-3

    authors: Nikolsky Y,Nikolskaya T,Bugrim A

    更新日期:2005-05-01 00:00:00

  • Noncoding RNA and epigenetic gene regulation in renal diseases.

    abstract::Kidneys have a major role in normal physiology and metabolic homeostasis. Loss or impairment of kidney function is a common occurrence in several metabolic disorders, including hypertension and diabetes. Chronic kidney disease (CKD) affect nearly 10% of the population worldwide; ranks 18th in the list of causes of dea...

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    doi:10.1016/j.drudis.2017.04.020

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    doi:10.1016/j.drudis.2016.06.010

    authors: Simões AE,Rodrigues CM,Borralho PM

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    journal_title:Drug discovery today

    pub_type: 历史文章,杂志文章

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    journal_title:Drug discovery today

    pub_type: 杂志文章,评审

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    authors: Findling O,Sellner J

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    abstract::Records about the traditional uses of medicinal plants can be considered useful in bioprospecting (i.e., the search for new active agents or lead structures in nature). Several sources like Egyptian papyri, early modern herbals and pharmacopoeias have been studied in this respect. It is proposed to use recordings of b...

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    authors: Helmstädter A

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    journal_title:Drug discovery today

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    authors: Tao SL,Desai TA

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    journal_title:Drug discovery today

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    authors: Zeidler R,de Freitas Soares BL,Bader A,Giri S

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    doi:10.1016/j.drudis.2013.01.001

    authors: Wu B,Li S,Dong D

    更新日期:2013-06-01 00:00:00

  • Targeting mutant huntingtin for the development of disease-modifying therapy.

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    journal_title:Drug discovery today

    pub_type: 杂志文章,评审

    doi:10.1016/j.drudis.2012.06.017

    authors: Appl T,Kaltenbach L,Lo DC,Terstappen GC

    更新日期:2012-11-01 00:00:00

  • Using germ-line genetic variation to investigate and treat cancer.

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    journal_title:Drug discovery today

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    journal_title:Drug discovery today

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    authors: Ekins S,Waller CL,Bradley MP,Clark AM,Williams AJ

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