Computational systems biology approaches to anti-angiogenic cancer therapeutics.

Abstract:

:Angiogenesis is an exquisitely regulated process that is required for physiological processes and is also important in numerous diseases. Tumors utilize angiogenesis to generate the vascular network needed to supply the cancer cells with nutrients and oxygen, and many cancer drugs aim to inhibit tumor angiogenesis. Anti-angiogenic therapy involves inhibiting multiple cell types, molecular targets, and intracellular signaling pathways. Computational tools are useful in guiding treatment strategies, predicting the response to treatment, and identifying new targets of interest. Here, we describe progress that has been made in applying mathematical modeling and bioinformatics approaches to study anti-angiogenic therapeutics in cancer.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Finley SD,Chu LH,Popel AS

doi

10.1016/j.drudis.2014.09.026

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

187-97

issue

2

eissn

1359-6446

issn

1878-5832

pii

S1359-6446(14)00395-X

journal_volume

20

pub_type

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