Abstract:
:The intestinal epithelium is the main barrier restricting the oral delivery of low-permeability drugs. Over recent years, numerous nanocarriers have been designed to improve the efficiency of oral drug delivery. However, the intracellular processes determining the transport of nanocarriers across the intestinal epithelium remain elusive, and only limited enhancement of the oral bioavailability of drugs has been achieved. Here, we review the processes involved in nanocarrier trafficking across the intestinal epithelium, including apical endocytosis, intracellular transport, and basolateral exocytosis. Understanding the complex intracellular processes of nanocarrier trafficking is particularly essential for the rational design of oral drug delivery systems.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Fan W,Xia D,Zhu Q,Hu L,Gan Ydoi
10.1016/j.drudis.2016.04.007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
856-63issue
5eissn
1359-6446issn
1878-5832pii
S1359-6446(16)30111-8journal_volume
21pub_type
杂志文章,评审abstract::With the aging of the general population, there is an increasing need for bone defect repair, prompting the development of reliable alternatives to autologous bone grafting, without the usually associated major drawbacks (i.e., limited volume and severe postoperative pain). Given the crucial role that miRNAs appear to...
journal_title:Drug discovery today
pub_type: 杂志文章,评审
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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