Abstract：
:The eventual candidate drug (CD) is often already synthesized during early drug discovery but not nominated until much later. To facilitate the rapid identification of a potential CD, a thoroughly worked-out CD target profile (CDTP) with criteria acceptable for the disease target product profile (TPP) is required at the start of lead generation (LG). In addition to driving the compound property optimization, the preclinical project team has to understand the ultimate goal to be able to rapidly identify and progress a potential CD. A screening cascade with meaningful and well-balanced progression criteria based on the CDTP is required to rapidly filter out unwanted compounds and to progress a potential CD through the cascade to candidate selection.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Bergström F,Lindmark Bdoi
10.1016/j.drudis.2019.03.026subject
Has Abstractpub_date
2019-06-01 00:00:00pages
1237-1241issue
6eissn
1359-6446issn
1878-5832pii
S1359-6446(18)30343-Xjournal_volume
24pub_type
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journal_title：Drug discovery today
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