Nuclear transport as a target for cell growth.

Abstract:

:The function of many key proteins and transcription factors involved in cell growth can be regulated by their cellular localization. Such proteins include the tumor suppressor p53 and the nuclear factor kappaB. Although the idea of trapping such proteins in either the nucleus or cytoplasm has been introduced as a potential therapeutic target, only two nuclear transport inhibitors have been reported. Here, we explore the roles of small-molecule inhibitors that cause target proteins to sequester in either the nucleus or cytoplasm. Methods of artificially targeting proteins to the nucleus or cytoplasm using peptide aptamer technology are also discussed.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Kau TR,Silver PA

doi

10.1016/s1359-6446(02)02562-x

subject

Has Abstract

pub_date

2003-01-15 00:00:00

pages

78-85

issue

2

eissn

1359-6446

issn

1878-5832

pii

S135964460202562X

journal_volume

8

pub_type

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