Abstract:
:The irreversible glycation and oxidation of proteins and lipids produces advanced glycation end products (AGEs). These modified AGEs are triggered to bind the receptor for AGE (RAGE), thereby activating its downstream signaling pathways, such as nuclear factor (NF)-κB and phosphoinositide 3-kinase (PI3K)/Akt, ultimately leading to diabetes and cancers. In this review, we focus on the interaction of AGE-RAGE and their associated pathways. We also consider the activity of phytochemicals, such as genistein and curcumin, that trap dicarbonyl compounds including methylglyoxal (MG) and glyoxalase that arise from multiple pathways to block AGE formation and prevent its interaction with RAGE.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Dariya B,Nagaraju GPdoi
10.1016/j.drudis.2020.07.003subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1614-1623issue
9eissn
1359-6446issn
1878-5832pii
S1359-6446(20)30262-2journal_volume
25pub_type
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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