Abstract：
:Healthcare systems are faced with the challenge of providing innovative treatments, while shouldering high drug costs that pharmaceutical companies justify by the high costs of R&D. An emergent technology that could transform R&D efficiency is organ-on-a-chip. The technology bridges the gap between preclinical testing and human trials through better predictive models, significantly impacting R&D costs. Here, we present an expert survey on the future role of organ-on-a-chip in drug discovery and its potential quantitative impact. We find that the technology has the potential to reduce R&D costs significantly, driven by changes in direct costs, success rates and the length of the R&D process. Finally, we discuss regulatory challenges to efficiency improvements.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Franzen N,van Harten WH,Retèl VP,Loskill P,van den Eijnden-van Raaij J,IJzerman Mdoi
10.1016/j.drudis.2019.06.003subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1720-1724issue
9eissn
1359-6446issn
1878-5832pii
S1359-6446(19)30042-Xjournal_volume
24pub_type
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