The case for a rational genome-based vaccine against malaria.

abstract：:During the pre-erythrocytic asymptomatic phase of malarial infection, sporozoites develop transiently inside less than 100 hepatocytes that subsequently release thousands of merozoites. Killing of these hepatocytes by cytotoxic T cells (CTLs) confers protection to subsequent malarial infection, suggesting that this bo...

journal_title：Frontiers in microbiology

authors： Bertolino P,Bowen DG

更新日期：2015-02-18 00:00:00

abstract：:The phytopathogen Xylella fastidiosa causes economic losses in important agricultural crops. Xylem vessel occlusion caused by biofilm formation is the major mechanism underlying the pathogenicity of distinct strains of X. fastidiosa. Here, we provide a detailed in vitro characterization of the extracellular proteins o...

journal_title：Frontiers in microbiology

authors： Mendes JS,Santiago AS,Toledo MA,Horta MA,de Souza AA,Tasic L,de Souza AP

更新日期：2016-12-26 00:00:00

abstract：:In Taiwan, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in 2006 and a PCV13 national childhood catchup program was implemented in 2013. To delineate the trend of serotype distribution and antimicrobial susceptibility following vaccination programs, we investigated a total of 1845 Streptococcus pne...

journal_title：Frontiers in microbiology

authors： Wu CJ,Lai JF,Huang IW,Shiau YR,Wang HY,Lauderdale TL

更新日期：2020-10-22 00:00:00

abstract：:The colon is inhabited by a dense population of microorganisms, the so-called "gut microbiota," able to ferment carbohydrates and proteins that escape absorption in the small intestine during digestion. This microbiota produces a wide range of metabolites, including short chain fatty acids (SCFA). These compounds are ...

journal_title：Frontiers in microbiology

authors： Ríos-Covián D,Ruas-Madiedo P,Margolles A,Gueimonde M,de Los Reyes-Gavilán CG,Salazar N

更新日期：2016-02-17 00:00:00

abstract：:Leishmaniasis comprises a spectrum of parasitic diseases caused by protozoans of the genus Leishmania. Molecular tools have been widely employed for the detection of Leishmania due to its high sensitivity and specificity. However, the analytical performance of molecular platforms as PCR and real time PCR (qPCR) includ...

journal_title：Frontiers in microbiology

authors： León CM,Muñoz M,Hernández C,Ayala MS,Flórez C,Teherán A,Cubides JR,Ramírez JD

更新日期：2017-10-04 00:00:00

abstract：:The numerous perennial meltwater ponds distributed throughout Antarctica represent diverse and productive ecosystems central to the ecological functioning of the surrounding ultra oligotrophic environment. The dominant taxa in the pond benthic communities have been well described however, little is known regarding the...

journal_title：Frontiers in microbiology

authors： Archer SD,McDonald IR,Herbold CW,Lee CK,Cary CS

更新日期：2015-05-27 00:00:00

abstract：:RNA viruses have a great potential for genetic variation, rapid evolution and adaptation. Characterization of the genetic variation of viral populations provides relevant information on the processes involved in virus evolution and epidemiology and it is crucial for designing reliable diagnostic tools and developing e...

journal_title：Frontiers in microbiology

authors： Rubio L,Guerri J,Moreno P

更新日期：2013-06-26 00:00:00

abstract：:This study was designed to evaluate the protection mechanism of oral administration of Clostridium butyricum against Salmonella enteritidis (SE) colonization in broilers. In the current study, 180 one-day-old healthy Arbor Acres (AA) broilers were meanly grouped into three, with three replicates of 20 birds each. An n...

journal_title：Frontiers in microbiology

authors： Zhao X,Yang J,Wang L,Lin H,Sun S

更新日期：2017-08-09 00:00:00

abstract：:Many chronic inflammatory diseases are known to be caused by persistent bacterial or viral infections. A well-studied example is the tick-borne infection by the gram-negative spirochaetes of the genus Borrelia in humans and other mammals, causing severe symptoms of chronic inflammation and subsequent tissue damage (Ly...

journal_title：Frontiers in microbiology

authors： Binder SC,Telschow A,Meyer-Hermann M

更新日期：2012-03-22 00:00:00

abstract：:Human rhinoviruses (HRVs) are the main cause of cold-like illnesses, and currently no vaccine or antiviral therapies against HRVs are available to prevent or mitigate HRV infection. There are more than 150 antigenically heterogeneous HRV serotypes, with ∼90 HRVs belonging to major group species A and B. Development of...

journal_title：Frontiers in microbiology

authors： Patel MC,Pletneva LM,Boukhvalova MS,Vogel SN,Kajon AE,Blanco JCG

更新日期：2017-08-31 00:00:00

abstract：:The time-to-result for culture-based microorganism recovery and phenotypic antimicrobial susceptibility testing necessitates initial use of empiric (frequently broad-spectrum) antimicrobial therapy. If the empiric therapy is not optimal, this can lead to adverse patient outcomes and contribute to increasing antibiotic...

journal_title：Frontiers in microbiology

authors： Pesesky MW,Hussain T,Wallace M,Patel S,Andleeb S,Burnham CD,Dantas G

更新日期：2016-11-28 00:00:00

abstract：:Acute respiratory infection (ARI) is the most frequent cause for hospitalization in infants and young children. Using multiplexed nCounter technology to digitally quantify 600 human mRNAs in parallel with 14 virus- and 5 bacterium-specific RNAs, we characterized viral and bacterial presence in nasopharyngeal aspirates...

journal_title：Frontiers in microbiology

authors： Fukutani KF,Nascimento-Carvalho CM,Bouzas ML,Oliveira JR,Barral A,Dierckx T,Khouri R,Nakaya HI,Andrade BB,Van Weyenbergh J,de Oliveira CI

更新日期：2018-11-09 00:00:00

abstract：:Microorganisms are able to adapt to different environments and evolve rapidly, allowing them to cope with their new environments. Such adaptive response and associated protections toward other lethal stresses, is a crucial survival strategy for a wide spectrum of microorganisms, including food spoilage bacteria, patho...

journal_title：Frontiers in microbiology

authors： Desriac N,Broussolle V,Postollec F,Mathot AG,Sohier D,Coroller L,Leguerinel I

更新日期：2013-10-02 00:00:00

abstract：:Early nutrition of pullets could determine the overall development and the performance of laying hens. With the aim to reduce the use of antibiotic growth promoters (AGPs) and to maintain the growth and development of pullets, the effect of simultaneous short-termed supplementation of AGPs (bacitracin zinc 20 mg/kg an...

journal_title：Frontiers in microbiology

authors： Li X,Wu S,Li X,Yan T,Duan Y,Yang X,Duan Y,Sun Q,Yang X

更新日期：2018-10-12 00:00:00

abstract：:Gut microbes play a crucial role in the development of colorectal cancer. Chitooligosaccharides (COS), are oligomer that are depolymerized from chitosan and possess a wide range of biological activities. In this study, the effects of COS on colorectal cancer (CRC) development were evaluated using azoxymethane and dext...

journal_title：Frontiers in microbiology

authors： Wu M,Li J,An Y,Li P,Xiong W,Li J,Yan D,Wang M,Zhong G

更新日期：2019-09-18 00:00:00

abstract：:We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the ...

journal_title：Frontiers in microbiology

authors： Guzmán-Herrador DL,Steiner S,Alperi A,González-Prieto C,Roy CR,Llosa M

更新日期：2017-08-22 00:00:00

abstract：:Many bacteria regulate gene expression in response to phosphate availability using a two-component signal transduction system, the activity of which is controlled by interaction with the Pst phosphate specific transporter and a cytoplasmic protein PhoU. Mycobacterium tuberculosis, the causative agent of tuberculosis, ...

journal_title：Frontiers in microbiology

authors： Brokaw AM,Eide BJ,Muradian M,Boster JM,Tischler AD

更新日期：2017-12-18 00:00:00

abstract：:Microbial interactions play a key role in ecosystem functioning, with nutrient availability as an important determinant. Although phylogenetically distant bacteria and fungi commonly co-occur in nature, information on their cross-kingdom interactions under unstable, extreme environments remains poor. Hence, the aims o...

journal_title：Frontiers in microbiology

authors： Velez P,Espinosa-Asuar L,Figueroa M,Gasca-Pineda J,Aguirre-von-Wobeser E,Eguiarte LE,Hernandez-Monroy A,Souza V

更新日期：2018-08-06 00:00:00

abstract：:Shewanella oneidensis is one of the best-understood model organisms for extracellular electron transfer. Endogenously produced and exported flavin molecules seem to play an important role in this process and mediate the connection between respiratory enzymes on the cell surface and the insoluble substrate by acting as...

journal_title：Frontiers in microbiology

authors： Arinda T,Philipp LA,Rehnlund D,Edel M,Chodorski J,Stöckl M,Holtmann D,Ulber R,Gescher J,Sturm-Richter K

更新日期：2019-02-05 00:00:00

abstract：:Purification of the origin recognition complex (ORC) from wild-type budding yeast cells more than two decades ago opened up doors to analyze the initiation of eukaryotic chromosomal DNA replication biochemically. Although revised methods to purify ORC from overproducing cells were reported later, purification of mutan...

journal_title：Frontiers in microbiology

authors： Kawakami H,Ohashi E,Tsurimoto T,Katayama T

更新日期：2016-04-18 00:00:00

abstract：:Cyclic lipodepsipeptides produced by Pseudomonas spp. (Ps-CLPs) are biosurfactants that constitute a diverse class of versatile bioactive natural compounds with promising application potential. While chemically diverse, they obey a common structural blue-print, allowing the definition of 14 distinct groups with multip...

journal_title：Frontiers in microbiology

authors： Geudens N,Martins JC

更新日期：2018-08-14 00:00:00

abstract：:Agricultural plastic mulch films are widely used in specialty crop production systems because of their agronomic benefits. Biodegradable plastic mulches (BDMs) offer an environmentally sustainable alternative to conventional polyethylene (PE) mulch. Unlike PE films, which need to be removed after use, BDMs are tilled ...

journal_title：Frontiers in microbiology

authors： Bandopadhyay S,Martin-Closas L,Pelacho AM,DeBruyn JM

更新日期：2018-04-26 00:00:00

abstract：:Marine microorganisms, particularly those residing in coastal areas, may come in contact with any number of chemicals of environmental or xenobiotic origin. The sensitivity and response of marine cyanobacteria to such chemicals is, at present, poorly understood. We have looked at the transcriptional response of well c...

journal_title：Frontiers in microbiology

authors： Tetu SG,Johnson DA,Varkey D,Phillippy K,Stuart RK,Dupont CL,Hassan KA,Palenik B,Paulsen IT

更新日期：2013-08-16 00:00:00

abstract：:Currently, the most utilized antimicrobial in processing facilities is peracetic acid, PAA; however, this chemical is increasingly recognized as a hazard to human health. Preliminary evidence suggests that ozone, when introduced in a specific manner, can reduce the noxious nature of PAA. Therefore, the objective of th...

journal_title：Frontiers in microbiology

authors： Dittoe DK,Feye KM,Peyton B,Worlie D,Draper MJ,Ricke SC

更新日期：2019-01-08 00:00:00

abstract：:Increased use of vancomycin has led to the emergence of vancomycin-intermediate Staphylococcus aureus (VISA). To investigate the mechanism of VISA development, 39 methicillin-susceptible strains and 3 MRSA strains were treated with vancomycin to induce non-susceptibility, and mutations in six genes were analyzed. All ...

journal_title：Frontiers in microbiology

authors： Wang Y,Li X,Jiang L,Han W,Xie X,Jin Y,He X,Wu R

更新日期：2017-01-10 00:00:00

abstract：:Plant defensins are active against plant and human pathogenic fungi (such as Candida albicans) and baker's yeast. However, they are non-toxic to human cells, providing a possible source for treatment of fungal infections. In this study, we characterized the mode of action of the antifungal plant defensin HsAFP1 from c...

journal_title：Frontiers in microbiology

authors： Aerts AM,Bammens L,Govaert G,Carmona-Gutierrez D,Madeo F,Cammue BP,Thevissen K

更新日期：2011-03-16 00:00:00

abstract：Background:Tuberculosis (TB) and non-tuberculous mycobacteriosis are serious threats to health worldwide. A simple non-sequencing method is needed for rapid diagnosis, especially in less experienced hospitals, but there is no specific biomarker commonly used for all mycobacteria. The ku gene of the prokaryotic error-pr...

journal_title：Frontiers in microbiology

authors： Zhou L,Ma C,Xiao T,Li M,Liu H,Zhao X,Wan K,Wang R

更新日期：2019-08-13 00:00:00

abstract：:The compatible solute dimethylsulfoniopropionate (DMSP), made by many marine organisms, is one of Earth's most abundant organosulfur molecules. Many marine bacteria import DMSP and can degrade it as a source of carbon and/or sulfur via DMSP cleavage or DMSP demethylation pathways, which can generate the climate active...

journal_title：Frontiers in microbiology

authors： Liu J,Liu J,Zhang SH,Liang J,Lin H,Song D,Yang GP,Todd JD,Zhang XH

更新日期：2018-12-21 00:00:00

abstract：:Chagasic chronic cardiomyopathy is one of the most frequent and severe manifestations of Chagas disease, caused by the parasite Trypanosoma cruzi. The pathogenic and biochemical mechanisms responsible for cardiac lesions remain not completely understood, although it is clear that hypertrophy and subsequent heart dilat...

journal_title：Frontiers in microbiology

authors： Libisch MG,Faral-Tello P,Garg NJ,Radi R,Piacenza L,Robello C

更新日期：2018-08-16 00:00:00

abstract：:Lake Fryxell, situated in the McMurdo Dry Valleys of Antarctica, is an intriguing aquatic ecosystem because of its perennial ice cover, highly stratified water column, and extreme physicochemical conditions, which collectively restrict lake biodiversity to solely microbial forms. To expand our current understanding of...

journal_title：Frontiers in microbiology

authors： Baker JM,Vander Schaaf NA,Cunningham AMG,Hang AC,Reeves CL,Huffman ER,Riester CJ,Madigan MT,Sattley WM

更新日期：2019-02-06 00:00:00