Abstract：
:Leishmania infantum is a protozoan that causes visceral leishmaniasis, a potentially deadly neglected tropical disease. The gold standard for diagnosis has traditionally been detection of amastigotes in bone marrow or spleen aspirates, but this is an invasive procedure that carries the risk of serious complications. Newer PCR techniques are opening new avenues and tissues for testing. Therefore, we tested if amastigotes and DNA from L. infantum could be detected in patient urine. We detected L. infantum DNA in six out of 30 urine samples from patients with visceral leishmaniasis and the promastigotes were isolated in culture from the urine of one patient. These results suggest the feasibility of using urine samples to diagnose visceral leishmaniasis, especially in acute cases or renal infection, providing a valuable tool for doctors and clinicians to use for screening and diagnosis of leishmaniasis in patients.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
da Costa Lima MS Junior,Hartkopf ACL,de Souza Tsujisaki RA,Oshiro ET,Shapiro JT,de Fatima Cepa Matos M,Cavalheiros Dorval MEdoi
10.1016/j.actatropica.2017.12.011subject
Has Abstractpub_date
2018-02-01 00:00:00pages
248-251eissn
0001-706Xissn
1873-6254pii
S0001-706X(17)30500-4journal_volume
178pub_type
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