Association of DDT and heptachlor epoxide in human blood with diabetic nephropathy.

Abstract:

:Six organochlorine pesticides and pesticide metabolites in human blood were tested to determine their relationships with diabetic nephropathy. The data were derived from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 (unweighted, n=2992, population estimate=133,088,752). The six chemicals were p,p'-DDT (dichlorodiphenyltrichloroethane), p,p'-DDE (dichlorodiphenyltrichloroethylene), beta-hexachlorocyclohexane, oxychlordane, trans-nonachlor and heptachlor epoxide. In this research, total diabetes included diagnosed and undiagnosed diabetes (glycohemoglobin, A1c ≥6.5%), and nephropathy was defined as a urinary albumin to creatinine ratio >30 mg/g, representing microalbuminuria and macroalbuminuria. The pesticide p,p'-DDT and pesticide metabolite heptachlor epoxide were significantly associated with total diabetes with nephropathy, with odds ratios of 2.08 (95% CI 1.06-4.11) and 1.75 (95% CI 1.05-2.93), respectively. Organochlorine pesticides are thought to act through the constitutive androstane receptor/pregnane X receptor disease pathway, but this is not well established. When p,p'-DDT and heptachlor epoxide were both elevated, the odds ratio for diabetic nephropathy was 2.76 (95% CI 1.31-5.81), and when six of six organochlorine pesticides and pesticide metabolites, were elevated, the odds ratio for diabetic nephropathy was 3.00 (95% CI 1.08-8.36). The differences in the odds ratios for these groups appear to be due to differences in the mean heptachlor epoxide concentration of each category. Organochlorine pesticides and pesticide metabolites are known to have estrogenic, antiestrogenic or antiandrogenic activity. The constitutive androstane receptor/pregnane X receptor pathway is thought to interact with the aryl hydrocarbon receptor pathway, and the associations noted may be due to that interaction.

journal_name

Rev Environ Health

authors

Everett CJ,Thompson OM

doi

10.1515/reveh-2015-0003

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

93-7

issue

2

eissn

0048-7554

issn

2191-0308

pii

/j/reveh.ahead-of-print/reveh-2015-0003/reveh-2015

journal_volume

30

pub_type

杂志文章
  • Public health impacts of global climate change.

    abstract::The potential health impacts of climate change are wide-ranging, from direct impacts at familiar local scales, through indirect effects occurring at the regional or ecosystem level, to long term effects on the sustainability of global systems. To assess these potential impacts, there is a need to broaden the scope of ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.1997.12.3.191

    authors: Hales S,Weinstein P,Woodward A

    更新日期:1997-07-01 00:00:00

  • Amyotrophic lateral sclerosis, occupational exposure to extremely low frequency magnetic fields and electric shocks: a systematic review and meta-analysis.

    abstract::Exposure to extremely low frequency magnetic fields (ELF-MF) and electric shocks occurs in many workplaces and occupations but it is unclear whether any of these exposures cause Amyotrophic lateral sclerosis (ALS). The aim of this systematic review and meta-analysis is to explore whether occupational exposure to ELF-M...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2020-0041

    authors: Jalilian H,Najafi K,Khosravi Y,Röösli M

    更新日期:2020-09-18 00:00:00

  • Sustainable development through a gendered lens: climate change adaptation and disaster risk reduction.

    abstract::The UN General Assembly has just adopted the post 2015 Sustainable Development Agenda articulated in the 17 Sustainable Development Goals (SDGs). Achieving the SDGs will be furthered by the closer integration of the climate change adaptation (CCA) and disaster risk reduction (DRR) agendas. Gender provides us a valuabl...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0077

    authors: Lewis ND

    更新日期:2016-03-01 00:00:00

  • Greater than the sum of its parts: focusing SRP research through a systems approach lens.

    abstract::AbstractThe National Institute of Environmental Health Sciences Superfund Research Program (SRP) funds diverse transdisciplinary research to understand how hazardous substances contribute to disease. SRP research focuses on how to prevent these exposures by promoting problem-based, solution-oriented research. SRP's ma...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2020-0073

    authors: Suk WA,Heacock M,Carlin DJ,Henry HF,Trottier BA,Lopez AR,Amolegbe SM

    更新日期:2020-08-31 00:00:00

  • Clean water and sanitation in developing areas lacking conventional power.

    abstract::Progress in providing clean water and sanitation throughout the developing world has been steady and encouraging, even though UN Millennium Development Goals will not be completely met. A number of important lessons have been learned along the way with respect to point-of-use water treatment and sanitation devices tha...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2014-0017

    authors: Leblanc M,Arnold NB,Arnold RG

    更新日期:2014-01-01 00:00:00

  • Pyrethroid pesticide exposure and hematological cancer: epidemiological, biological and molecular evidence.

    abstract::Pyrethroid insecticides are commonly used worldwide. The chronic effects of these compounds are of concern given that epidemiological studies have suggested an association with hematological cancer, particularly in children. However, the biological evidence at molecular and cellular levels is limited. A review on the ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2018-0070

    authors: Navarrete-Meneses MDP,Pérez-Vera P

    更新日期:2019-06-26 00:00:00

  • Risk of colorectal cancer from alcohol consumption at lower vitamin intakes. A hospital-based case-control study in Poland.

    abstract::The purpose of the study was to assess the relation between the simultaneous exposure to alcohol and consumption of micronutrients that have protective properties against colorectal cancer. A hospital-based case-control study of colorectal cancer was carried out between January 1998 and November 1999 at the University...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2001.16.3.213

    authors: Jedrychowski W,Steindorf K,Popiela T,Wahrendorf J,Tobiasz-Adamczyk B,Kulig J,Penar A

    更新日期:2001-07-01 00:00:00

  • Biomonitoring of occupational exposures to cytostatic anticancer drugs.

    abstract::Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers who are occupationally exposed during the preparation and administration of such drugs. During the last 20 years, several researchers have developed and validated methods to monitor occupational expos...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.1997.12.1.43

    authors: Bos RP,Sessink PJ

    更新日期:1997-01-01 00:00:00

  • Phenotypic characterization of human pathogenic bacteria in fish from the coastal waters of South West Cameroon: public health implications.

    abstract::Increasing economic and recreational opportunities, attractive scenery and a perception of a better quality of life are luring people to the coast. Unfortunately, these activities together with the commensurate increase in population in the area inevitably result in pollution of coastal waters with excessive microorga...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2009.24.2.147

    authors: Akoachere JF,Bughe RN,Oben BO,Ndip LM,Ndip RN

    更新日期:2009-04-01 00:00:00

  • Bayesian networks in infectious disease eco-epidemiology.

    abstract::Globally, infectious diseases are responsible for a significant burden on human health. Drivers of disease transmission depend on interactions between humans, the environment, vectors, carriers, and pathogens; transmission dynamics are therefore potentially highly complex. Research in infectious disease eco-epidemiolo...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0052

    authors: Lau CL,Smith CS

    更新日期:2016-03-01 00:00:00

  • Variations of cortisol, fatigue and sleep disturbances in sound engineers: effect of job task and fast backward-rotating shifts.

    abstract::The aim was to study the effect of job task and fast backward-rotating shifts on the time-of-day variations of cortisol, fatigue, and sleep disturbances in broadcasting sound engineers. The concentration of saliva cortisol and ratings of stress, sleepiness, and fatigue were followed at 3-hour intervals during the fast...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2008.23.1.83

    authors: Vangelova KK

    更新日期:2008-01-01 00:00:00

  • Lead exposure from battery recycling in Indonesia.

    abstract::In Indonesia, more than 200 illegal used lead acid battery (ULAB) smelters are currently operating. Only a few health studies support the finding of lead-related symptoms and diseases among populations living near the smelters. To assess the blood lead levels (BLLs) and potential health impacts among the population su...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0036

    authors: Haryanto B

    更新日期:2016-03-01 00:00:00

  • Virus, bats and drugs.

    abstract::Apart from SARS-Co-V-2 coronavirus, bats also host many highly virulent zoonotic pathogens. A matter of rising concern is the detrimental impact of pharmaceuticals in the environment, as they can have major impact at low concentrations. Insectivorous bats are among the wildlife animals likely to be exposed due to the ...

    journal_title:Reviews on environmental health

    pub_type: 社论

    doi:10.1515/reveh-2020-0083

    authors: Orive G,Lertxundi U

    更新日期:2020-08-24 00:00:00

  • Proteomics of Sphingobium indicum B90A for a deeper understanding of hexachlorocyclohexane (HCH) bioremediation.

    abstract::Genome wide expression profiling of Sphingobium indicum B90A revealed induction of lin genes, linA and linB, involved in dechlorination of hexachlorocyclohexane (HCH), in the presence of all four isomers of HCH. Supporting proteomics data, the qPCR and promoter assay showed upregulation of linA transcription in the pr...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0042

    authors: Nandavaram A,Sagar AL,Madikonda AK,Siddavattam D

    更新日期:2016-03-01 00:00:00

  • Reconciling PM10 analyses by different sampling methods for Iron King Mine tailings dust.

    abstract::The overall project objective at the Iron King Mine Superfund site is to determine the level and potential risk associated with heavy metal exposure of the proximate population emanating from the site's tailings pile. To provide sufficient size-fractioned dust for multi-discipline research studies, a dust generator wa...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0061

    authors: Li X,Félix OI,Gonzales P,Sáez AE,Ela WP

    更新日期:2016-03-01 00:00:00

  • The effects of radiofrequency (< 30 MHz) radiation in humans.

    abstract::121 workers who were exposed to RFR (< 30 MHz) over one year were examined. They were divided into two groups: one group was exposed to high electric field intensity (> or = 100 V/m), another to low intensity (< 100 V/m) and both groups were compared to control subjects. No significant changes in the functioning of th...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:

    authors: Zhao Z,Zhang S,Zho H,Zhang S,Su J,Li L

    更新日期:1994-07-01 00:00:00

  • European aspects of standard setting in occupational hygiene and medicine.

    abstract::Occupational standards concerning the allowable concentrations of chemical compounds in the ambient air of workplaces have been established in several countries at national levels. With the integration of the European Union, a need exists for establishing harmonized Occupational Exposure Limits. For analytical develop...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2001.16.2.81

    authors: Thier R,Bolt HM

    更新日期:2001-04-01 00:00:00

  • Environmental stressors and violence: lead and polychlorinated biphenyls.

    abstract::Many environmental risk factors for antisocial and violent behavior have been described. In recent years, this topic has become widely researched in the fields of environmental health, psychology, sociology, and many other disciplines. The results from a myriad of studies have shown that the etiologies of violent and ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2007.22.4.313

    authors: Hwang L

    更新日期:2007-10-01 00:00:00

  • Diseases associated with poor water and sanitation: hazards, prevention, and solutions.

    abstract::This paper examines one of the most staggering challenges facing the mankind, the challenge to conquer diseases associated with poor water and sanitation. Although rapid strides have been made in the last decade of the last century to provide improved water supply and sanitation, the world is still rampant with diseas...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2003.18.1.33

    authors: Kulshrestha M,Mittal AK

    更新日期:2003-01-01 00:00:00

  • Using human epidemiological analyses to support the assessment of the impacts of coal mining on health.

    abstract::The potential impacts of coal mining on health have been addressed by the application of impact assessment methodologies that use the results of qualitative and quantitative analyses to support their conclusions and recommendations. Although human epidemiological analyses can provide the most relevant measures of risk...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2019-0033

    authors: Cortes-Ramirez J,Sly PD,Ng J,Jagals P

    更新日期:2019-12-18 00:00:00

  • An evaluation of waterborne disease surveillance in the European Union.

    abstract::Surveillance systems to inform controls for waterborne disease (WBD) are important for the protection of public health. Member States of the European Union (EU) will soon be required to implement Directives and the Protocol on Water and Health for controlling WBD. The investigation reported here considers the consiste...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2002.17.2.149

    authors: Poullis DA,Attwell RW,Powell SC

    更新日期:2002-04-01 00:00:00

  • Residential environment and health: a review of methodological and conceptual issues.

    abstract::Geographic patterns of poor health and mortality risk are found in most countries. Important health effects at the neighborhood level are mortality, general health, illness and disabilities, mental health, and healthcare utilization. Awareness of the influence of social class on health has been growing during the last...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:

    authors: van Kamp I,van Loon J,Droomers M,de Hollander A

    更新日期:2004-07-01 00:00:00

  • Environmental victims: environmental injustice issues that threaten the health of children living in poverty.

    abstract::Children living in poverty are disproportionately at risk from and affected by environmental hazards. According to the National Center for Children in Poverty, 13 million children in America live in poverty. Thus, not only are millions of children living in poverty but are also living in environments that are hazardou...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2011.021

    authors: Cureton S

    更新日期:2011-01-01 00:00:00

  • Gender differences in the relationship between housing, socioeconomic status, and self-reported health status.

    abstract::This study investigates gender differences in housing, socioeconomic status, and self-reported health status. The analysis focuses on the social and economic dimensions of housing, such as demand, control, material aspects (affordability, type of dwelling) and meaningful aspects (pride in dwelling, home as a refuge) o...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:

    authors: Dunn JR,Walker JD,Graham J,Weiss CB

    更新日期:2004-07-01 00:00:00

  • An overview of indoor air quality and its impact on respiratory health among Malaysian school-aged children.

    abstract::The indoor environment is a major source of human exposure to pollutants. Some pollutants can have concentrations that are several times higher indoors than outdoors. Prolonged exposure may lead to adverse biologic effects, even at low concentrations. Several studies done in Malaysia had underlined the role of indoor ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2014-0065

    authors: Choo CP,Jalaludin J

    更新日期:2015-01-01 00:00:00

  • Industrial monosulfhydryl hydrocarbon compounds-a toxicological and pharmacokinetic profile.

    abstract::The relevant published toxicological and pharmacokinetic data on the effects of industrial monosulfhydryl hydrocarbon (MSHC) compounds in humans and animals have been reviewed. These compounds are of occupational and environmental exposure concern to humans because they are manufactured in significant quantities, wide...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:

    authors: Das BR,Shah HC

    更新日期:1980-01-01 00:00:00

  • Neurotoxic effects and biomarkers of lead exposure: a review.

    abstract::Lead, a systemic toxicant affecting virtually every organ system, primarily affects the central nervous system, particularly the developing brain. Consequently, children are at a greater risk than adults of suffering from the neurotoxic effects of lead. To date, no safe lead-exposure threshold has been identified. The...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2009.24.1.15

    authors: Sanders T,Liu Y,Buchner V,Tchounwou PB

    更新日期:2009-01-01 00:00:00

  • Variability of phthalate monoester levels in daily first-morning urine from adult women: a pilot study.

    abstract::Phthalate exposure is ubiquitous and may affect child and adolescent health through both in utero exposure and direct exposure during childhood. Variability in exposure within women is not well documented. We analyzed 90 first-morning urine samples collected by ten reproductive-age women for phthalate metabolites and ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2010.25.4.359

    authors: Marcus M,Christensen KY,Manatunga A,Rudra CB,Brock JW,Small CM

    更新日期:2010-10-01 00:00:00

  • Human ecology in understanding environmental health problems.

    abstract::The role of human ecology in understanding of environmental health problems is discussed, and the importance of study on "regional" ecosystems is emphasized in consideration of recent arguments on theoretical frame work of human ecology. After brief conceptual discussion on "regional" ecosystems, the environmental hea...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:

    authors: Suzuki T

    更新日期:1977-01-01 00:00:00

  • Increased mercury release from dental amalgam restorations after exposure to electromagnetic fields as a potential hazard for hypersensitive people and pregnant women.

    abstract::Over the past decades, the use of common sources of electromagnetic fields such as Wi-Fi routers and mobile phones has been increased enormously all over the world. There is ongoing concern that exposure to electromagnetic fields can lead to adverse health effects. It has recently been shown that even low doses of mer...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2015-0017

    authors: Mortazavi G,Mortazavi SM

    更新日期:2015-01-01 00:00:00