Abstract：
:The ferlin family proteins have emerged as multi-C2 domain regulators of calcium-triggered membrane fusion and fission events. While initially determined to share many of the features of members of the synaptotagmin family of calcium sensors, ferlins in more recent studies have been found to interact directly with non-neuronal voltage-gated calcium channels and nucleate the assembly of membrane-trafficking protein complexes, functions that distinguish them from the more well studied members of the synaptotagmin family. Here we highlight some of the recent findings that have advanced our understanding of ferlins and their functional differences with the synaptotagmin family.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Johnson CPdoi
10.1021/acs.biochem.7b00928subject
Has Abstractpub_date
2017-12-12 00:00:00pages
6413-6417issue
49eissn
0006-2960issn
1520-4995journal_volume
56pub_type
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