Abstract：
OBJECTIVES:To move towards a more standardized approach in clinical practice to manage patients with castration-resistant prostate cancer (CRPC) in Spain. METHODS:A panel of 18 Spanish experts in Urology with expertise managing CRPC followed a modified Delphi process with two rounds and a final face-to-face consensus meeting. The panel considered a total of 106 clinical questions divided into the following 6 sections: definition of CRPC, diagnosis of metastases by imaging techniques, symptoms of CRPC, progression of CRPC, M0 and M1 management and therapeutic sequencing. RESULTS:A bone scan (BS) is recommended at diagnosis, at the onset of bone pain, and depending on PSA levels, but it is not sensitive enough to confirm or exclude bone metastases if there is bone pain. Whole-body MRI and axial MRI are more sensitive than BS and plain X-rays, but more expensive, so they have to be used in certain situations. There is CRPC progression when there is radiologic, clinical or confirmed PSA progression. Flare phenomenon appears in treatment with taxanes and abiraterone. It was agreed that in M0 CRPC patients no drug treatment is currently recommended, although in M1 CRPC patients the first-line therapy would be mainly enzalutamide/abiraterone and/or docetaxel, depending on the symptom burden. CONCLUSION:After the consensus, we provide a series of recommendations for Spanish physicians treating CRPC to address the disease characteristics,how to tailor patient management decisions, the use of imaging techniques, and how to handle disease progression appropriately to improve patients' quality of life.
journal_name
Arch Esp Uroljournal_title
Archivos espanoles de urologiaauthors
Alcaraz A,Martínez-Piñeiro L,Rodríguez A,Rubio J,Borque Á,Burgos J,Carballido J,Cózar JM,Crespo I,Esquena S,Gómez-Veiga F,López D,Miñana B,Morote J,Ribal MJ,Solsona E,Suárez JF,Unda Msubject
Has Abstractpub_date
2017-11-01 00:00:00pages
777-791issue
9eissn
0004-0614issn
1576-8260journal_volume
70pub_type
共识发展会议,杂志文章abstract：:Holmium laser enucleation of the prostatic adenoma (HoLEP) represents an innovative surgical option for the treatment of bladder outlet obstruction caused by benign prostatic hypertrophy. The results of numerous randomized prospective studies and clinical case series have confirmed that HoLEP is a procedure that attai...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2011-04-01 00:00:00
abstract：:Transitional cell carcinoma of the upper urinary tract (UUT-TCC) is relatively uncommon, accounting for 2-5% of all urothelial tumors. Its incidence appears to be increasing as a result of progress in imaging, endoscopy, and improved survival from bladder cancer. Renal pelvis tumors represent 10% of all renal cancers....
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142008000900018
更新日期：2008-11-01 00:00:00
abstract：:The Goddess of Health had two daughters, Panacea and Higinia, the fruit of the first is diagnosis, prognosis and treatment, and the fruit of the second is health management, prevention, and statistics. Humanbeings are unexpectedly subjected to:1. Happenings: they belong to the plane of the personality, crisis, the Age...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2020-06-01 00:00:00
abstract：:The authors report on two male neonates who underwent transurethral resection of urethral valves in one case and a polyp in the posterior urethra in the other case, via antegrade percutaneous cystostomy. The percutaneous antegrade approach to the urethra is described in detail. The advantages afforded by this procedur...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVES:Extracorporeal shock wave lithotripsy is a minimally invasive therapeutic option for the treatment of renal-ureteral lithiasis. The aim of this study was to analyze the results and complications of shock wave extracorporeal lithotripsy treatment with the Dornier Gemini® Generator EMSE 220f-XXP device in pati...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:To analyze the therapeutic approach in epidermoid or squamous cell carcinoma of the scrotum, a rare tumor that is of interest for clinical and historical reasons. METHODS/RESULTS:A case of epidermoid carcinoma of the scrotum is described. The patient had undergone urethroplasty in 1972, using preputial free ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:To review the utility of MR imaging in the assessment of renal masses, with special reference to the morphological characteristics of the different tumor types. Staging of renal cell carcinoma is also discussed. METHODS:The literature on the use of MRI in the evaluation of renal masses is reviewed. The techn...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVES:To present a series of four cases of Gartner cysts and their clinical presentation. A bibliographic review was performed. METHODS:The series consisted of 4 women, mean age 39, who complained of a bulge at the anterior vaginal wall, associated with a variety of urinary symptoms. RESULTS:Surgical removal was...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:The authors present a case of sarcomatoid kidney adenocarcinome of the fibrosarcomatoid kind. They stress the importance and difficulty of making a differential diagnosis between the sarcomatoid type of kidney adenocarcinomas and pure sarcomas of the kidney, this being an entirely histopathological and extremely compl...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1978-07-01 00:00:00
abstract：OBJECTIVES:To determine the type and to quantify the DURR phenomena in the male. METHODS:We conducted a clinical and urodynamic study in 31 male patients with functional lower urinary tract symptoms. RESULTS:DURR is produced by two types of mechanisms: urethral rigidity and contraction of the urethral wall. The patie...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:The monohydrate calcium oxalate lithiasis (MCO) is divided in two groups depending on the morphologic-crystal structure: papillary (anchorage point on a renal papilla lesion) and cavity (formed in a cavity with low urodynamic capacity). The minimal differences between urinary biochemistry of MCO makers in co...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142006000200005
更新日期：2006-03-01 00:00:00
abstract：:Urinary unidiversion permits the possibility of enhancing the quality of life and probably the survivorship of previously diverted patients. A modification of this technique is described which utilizes Brickne's loop and a segment of the sigmoid to create a low pressure bladder, thus sparing more intestine. The good r...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Double-J ureteral stents disposal is associated with the appearance of side effects in up to 90% of the patients. The main causes of these symptoms are related to stent's design and the materials they are manufactured from. Vesicoureteral reflux and bladder trigone irritation are the etiopathogenic causes of ureteral ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:The objective of this article is to show the current situation regarding two surgical techniques for the treatment of renal lithiasis, RIRS (Retrograde intrarenal surgery) and PCNL (Percutaneous nephrolithotomy), specially concerning the larger size stones. We perform a literature review on the topic and add...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the prognostic significance of the 2002 TNM tumor classification for renal cell carcinoma, as well as other factors intervening in its survival. METHODS:Retrospective chart review of 316 renal carcinomas operated between 1970 and 2003. Twenty-five prognostic variables were analyzed. RESULTS:The...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142007000200004
更新日期：2007-03-01 00:00:00
abstract：:We made a crystallographic analysis of 87 mixed-nucleus stones and found 4 groups of stones of this kind, which are as follow: urico-oxalic, oxalico-uric, phosphato-oxalic and oxalic-phosphatic. We did not find any mixed-nucleus, urico-phosphatic or phosphatico-uric stones and we explain this fact according to the kno...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：:Papillary transitional cell carcinoma of the bladder (PTCCB) is characterized by a high recurrence rate with infiltration of bladder wall and surrounding tissues. The outcome is poor in 10-20% of the cases and these cannot be detected by conventional methods. Different methods have been utilized to identify this high ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To describe a case of crossed testicular ectopia that was diagnosed in a 52-year-old patient who had consulted for infertility associated with a genital anomaly. METHODS:Patient evaluation included hematological, hormonal, cytogenetic and imaging studies. An exploratory operation was also performed. RESULTS...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：:The present study was undertaken to determine the reliability of CAT scanning in the preoperative evaluation to detect or discard pelvic lymph node involvement in patients with infiltrating bladder tumor. We compared the radiologic findings with the results of histopathologic examination of the lymph nodes following l...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：OBJECTIVES:The pandemic caused by the new SARS / Cov-2 Coronavirus represents an unprecedented scenario in modern medicine that affects many aspects of daily healthcare. Lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) has a high prevalence and is related to high consumption of health resource...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2020-06-01 00:00:00
abstract：:Holmium laser has been established asthe gold-standard for the ureteroscopic management of urinary stone disease. However the role of laser inpercutaneous nephrolithotomy (PCNL) varies, as multiple energy sources and lithotripters are available. Currently, lasers are becoming more relevant with the development of seve...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2020-10-01 00:00:00
abstract：:We report a case of spontaneous retroperitoneal hematoma from rupture of the right adrenal in a patient with asymptomatic left renal adenocarcinoma that had been incidentally detected during evaluation to determine the cause of the retroperitoneal hematoma. ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:Indinavir is a protease inhibitor used in the treatment of HIV with a lithogenic capacity as a urological side effect. The pathogenesis, diagnosis and treatment of indinavir urolithiasis are briefly reviewed. METHODS:A 37-year-old male, seropositive for HIV on treatment with indinavir, lamiduvine and zidovud...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The present study reports on the urological complications observed in 700 kidney transplants performed from February, 1975 to January, 1993. The techniques used for reconstruction of the urinary tract have been extravesical and intravesical ureteroneocystostomy. In some cases other different techniques have been used....
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：OBJECTIVE:To report a case of primary bladder endometriosis treated with laparoscopic partial cystectomy. METHODS:We report the case of a 38 year old woman presenting with cyclic catamenial pain and hematuria who was diagnosed of bladder endometriosis by means of cystoscopy and MRI. Partial cystectomy using a laparosc...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:To record the findings from pelvic floor examination in an understandable way that permits the indication of a proper treatment. METHODS:We review classic classifications, as well as genital prolapse stages and degrees. We also record the POPQ examination system which is the established standard nowadays. ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To analyze if there is a learning curve to get to perform high quality ultrasound guided prostate biopsies that enable to effectively perform the diagnosis of prostate cancer, taking the pathological result of the samples into consideration. METHODS:We retrospectively reviewed data from 790 ultrasound-guided...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
abstract：:A simple endourological management of benign renal cyst is described. Percutaneous circular electrosection of the peripheric cyst wall is performed, thereafter the cyst wall is extracted en bloc and an aspirative drainage is placed for 2 days. Five patients with symptomatic renal cyst were treated with this method. No...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:A systematic review is characterized by the application of the scientific method to the evaluation of scientific literature. When a systematic review uses statistical techniques to combine and summarize the results from previous studies, it is called meta-analysis. Meta-analysis is a working tool that facilitates the ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVES:To review our series of nephrogenic adenoma and compare our results with those reported in the literature. METHOD:The records of our Department of Pathology were reviewed to determine the cases of nephrogenic adenoma diagnosed at our center. The clinical features, diagnostic aspects, pathological findings, ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
