[Urinary lithiasis secondary to indinavir in an HIV-positive patient].

Abstract:

OBJECTIVE:Indinavir is a protease inhibitor used in the treatment of HIV with a lithogenic capacity as a urological side effect. The pathogenesis, diagnosis and treatment of indinavir urolithiasis are briefly reviewed. METHODS:A 37-year-old male, seropositive for HIV on treatment with indinavir, lamiduvine and zidovudine, consulted for colicky left lumbar pain, nausea, vomiting and dark urine for the past three days. RESULTS:Patient evaluation showed a nonfunctioning left kidney and ureterohydronephrosis of unknown origin. URS showed a yellowish, friable material with a mucinous appearance that occupied the entire lumen of the ureter. Fragmentation was achieved with the lithotriptor probe. Six months later the patient had fully recovered and was asymptomatic. CONCLUSIONS:The incidence of protease inhibitor-induced urolithiasis is increasing. This condition should be distinguished from uric acid calculi whose treatment will aggravate the indinavir urolithiasis.

journal_name

Arch Esp Urol

authors

Moyano Calvo JL,Huesa Martínez I,Cruz Navarro N,Leal Arenas J,León Dueñas E,Morales López A,Maestro Durán JL,Ramírez Mendoza A

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1117-20

issue

10

eissn

0004-0614

issn

1576-8260

journal_volume

54

pub_type

杂志文章
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