Abstract:
BACKGROUND:Tic disorders, such as the Gilles de la Tourette syndrome and persistent tic disorder, are neurodevelopmental movement disorders involving impaired motor control. Hence, patients show repetitive unwanted muscular contractions in one or more parts of the body. A cognitive-behavioral therapy, with a particular emphasis on the psychophysiology of tic expression and sensorimotor activation, can reduce the frequency and intensity of tics. However, its impact on motor activation and inhibition is not fully understood. METHODS:To study the effects of a cognitive-behavioral therapy on electrocortical activation, we recorded the event-related potentials (ERP) and lateralized readiness potentials (LRP), before and after treatment, of 20 patients with tic disorders and 20 healthy control participants (matched on age, sex and intelligence), during a stimulus-response compatibility inhibition task. The cognitive-behavioral therapy included informational, awareness training, relaxation, muscle discrimination, cognitive restructuration and relapse prevention strategies. RESULTS:Our results revealed that prior to treatment; tic patients had delayed stimulus-locked LRP onset latency, larger response-locked LRP peak amplitude, and a frontal overactivation during stimulus inhibition processing. Both stimulus-locked LRP onset latency and response-locked LRP peak amplitude normalized after the cognitive behavioral therapy completion. However, the frontal overactivation related to inhibition remained unchanged following therapy. CONCLUSIONS:Our results showed that P300 and reaction times are sensitive to stimulus-response compatibility, but are not related to tic symptoms. Secondly, overactivity of the frontal LPC and impulsivity in TD patients were not affected by treatment. Finally, CBT had normalizing effects on the activation of the pre-motor and motor cortex in TD patients. These results imply specific modifications of motor processes following therapy, while inhibition processes remained unchanged. Given that LRPs are partially generated within the sensorimotor and supplementary motor area, the reported reduction in tic frequency and improvements of LRPs components suggest that CBT induced a physiological change in patients' motor area.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Morand-Beaulieu S,O'Connor KP,Sauvé G,Blanchet PJ,Lavoie MEdoi
10.1016/j.neuropsychologia.2015.05.024subject
Has Abstractpub_date
2015-12-01 00:00:00pages
310-21issue
Pt Beissn
0028-3932issn
1873-3514pii
S0028-3932(15)30039-7journal_volume
79pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::One subject (L.B.) with complete forebrain commissurotomy, another (D.K.) with posterior callosotomy, and 12 normal controls, were shown either single lights, simultaneous pairs, or successive pairs, presented either within the left or right visual fields or bilaterally. Regardless of location, all subjects scored at ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(95)00110-7
更新日期:1996-04-01 00:00:00
abstract::Changes in many domains of cognition occur with development. In this paper, we discuss neuroimaging approaches to understanding these changes at a neural level. We highlight how modern imaging methods such as functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) are being used to examine how ...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2005.10.010
更新日期:2006-01-01 00:00:00
abstract::Event-based prospective memory (PM) requires remembering the delayed execution of an intended action in response to a pre-specified PM cue while being actively engaged in an ongoing task in which the cue is embedded. To date, experimental paradigms vary as to whether or not they require participants immediately to sto...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.01.034
更新日期:2009-04-01 00:00:00
abstract::Our objective was to study the neural correlates of naming of newly learned unfamiliar objects in subjects with mild cognitive impairment (MCI) and in age-matched controls, by using positron emission tomography (PET). Prior to the PET scanning, each subject underwent a 4-day long training period in which 40 names of r...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2007.02.003
更新日期:2007-06-11 00:00:00
abstract::Understanding memory mechanisms is crucial in the study of infant social and cognitive development. Here, we show that the Nc ERP component, known to reflect frequency-related attentional and/or memory processes, is a good candidate to investigate infant recognition memory. Previous paradigms have only investigated th...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.08.023
更新日期:2019-03-18 00:00:00
abstract::The properties of errors made by normals and unilateral brain damaged patients in localizing points in each half of a plane have been further investigated. A lesion of either hemisphere affects specifically the performance in the left half of the plane, where controls attain the highest degree of constancy. Considerat...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(83)90028-3
更新日期:1983-01-01 00:00:00
abstract::This study investigated the cerebral correlates of the Trail Making Test (TMT), used commonly as a measure of frontal lobe function. Such work sheds additional light on the known shortcomings of the TMT as a localizing instrument, as indicated, for example, by studies of patients with focal brain lesions. Functional m...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2005.03.013
更新日期:2005-01-01 00:00:00
abstract::The direct access model of hemispheric asymmetry was tested in a letter reflection (normal of reflected) judgement task. In the baseline condition letters were presented in their upright orientation, and reaction times were faster to letters presented in the right visual field than to those presented in the left visua...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/0028-3932(88)90037-1
更新日期:1988-01-01 00:00:00
abstract::Findings of pharmacological studies that have investigated the involvement of specific regions of the brain in recognition memory are reviewed. The particular emphasis of the review concerns what such studies indicate concerning the role of the perirhinal cortex in recognition memory. Most of the studies involve rats ...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2012.07.034
更新日期:2012-11-01 00:00:00
abstract::Alzheimer's disease (AD), the most common neurodegenerative disorder of the elderly, ranks third in health care cost after heart disease and cancer. Given the disproportionate aging of the population in all developed countries, the socio-economic impact of AD will continue to rise. Mild cognitive impairment (MCI), a t...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2007.10.026
更新日期:2008-01-01 00:00:00
abstract::In two ERP experiments, we examined the attention-related mechanism involved in perceiving infant emotions following exposure to security priming. Specifically, we examined how security priming affected securely and insecurely attached women. We found that both supraliminal and subliminal security priming resulted in ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2019.107216
更新日期:2019-11-01 00:00:00
abstract::We tested achromatopsic observer, MS, on a number of tasks to establish the extent to which he can process chromatic contour. Stimuli, specified in terms of cone-contrast, were presented in a three-choice oddity paradigm. First we show that MS is able to discriminate the magnitude of chromatic and luminance contrast, ...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuropsychologia.2003.11.002
更新日期:2004-01-01 00:00:00
abstract::Event-related potentials (ERPs) were used to examine how individuals with aphasia and a group of age-matched controls use prosody and themattic fit information in sentences containing temporary syntactic ambiguities. Two groups of individuals with aphasia were investigated; those demonstrating relatively good sentence...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.10.023
更新日期:2017-12-01 00:00:00
abstract::While there is consistent evidence from neuropsychological and brain imaging studies for an association between the left angular gyrus and mental arithmetic, its specific role in calculation has remained poorly understood. It has been speculated that the angular gyrus mediates the retrieval of arithmetic facts during ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.10.013
更新日期:2009-01-01 00:00:00
abstract::Based on a recent metacognitive account, cognitive effort is the result of an inferential evaluation made over explicitly available cues. Following from this account, we present here a pre-registered experiment that tested the specific hypothesis that explicit awareness of cues that are aligned with cognitive demand i...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.05.011
更新日期:2019-02-04 00:00:00
abstract::In the present study, we examined whether individuals with cerebral palsy (CP) systematically vary motion of the trunk and co-contraction in the upper limb as a function of accuracy demands. Four participants with spastic tetraparesis, four with spastic hemiparesis, and four healthy controls were asked to repeatedly m...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2004.07.014
更新日期:2005-01-01 00:00:00
abstract::Providing evidence for categorical theories of emotion mandates the inclusion of discrete emotion categories beyond the typical six "basic" emotions. Traditional neurophysiological investigations of emotion typically feature the six basic emotions with happiness as the lone positive exemplar. Here we studied how event...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.12.001
更新日期:2016-03-01 00:00:00
abstract::Common polymorphisms in the gene PCSK6, whose protein product mediates the development of brain and body asymmetry through the NODAL pathway, have recently been associated with handedness in three studies, making it a key candidate gene for understanding the developmental and expression of human lateralization. We tes...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2016.02.020
更新日期:2016-04-01 00:00:00
abstract::Monkeys with crossed unilateral excitotoxic lesions of the anterior thalamus and unilateral inferotemporal cortex ablation were severely impaired at learning two tasks which required the integration of information about the appearance of objects and their positions in space. The lesioned monkeys were also impaired at ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2004.02.005
更新日期:2004-01-01 00:00:00
abstract::The discovery and description of the affected members of the KE family (aKE) initiated research on how genes enable the unique human trait of speech and language. Many aspects of this genetic influence on speech-related cognitive mechanisms are still elusive, e.g. if and how cognitive processes not directly involved i...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.11.027
更新日期:2018-01-08 00:00:00
abstract::The concepts of God and Devil are well known across many cultures and religions, and often involve spatial metaphors, but it is not well known if our mental representations of these concepts affect visual cognition. To examine if exposure to divine concepts produces shifts of attention, participants completed a target...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.09.029
更新日期:2010-01-01 00:00:00
abstract::Several neuroimaging studies showed that fulfilled expectations increase the magnitude of repetition suppression (RS) in the face-selective visual cortex. However, previous fMRI studies did not allow a distinction between the reductions of the response due to stimulus repetitions and fulfilled expectations (expectatio...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.12.017
更新日期:2015-01-01 00:00:00
abstract::The case of a patient with selective left hemispheric medial and lateral temporal lobe damage is described. The patient was of slightly supra-average intelligence and had no problems in normal memory functions, but was severely anomic with respect to people's names. One month post-onset, this deficit held for names of...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(96)00120-0
更新日期:1997-05-01 00:00:00
abstract::The phonological deficit hypothesis of dyslexia has been investigated in the present research by analysing language-related lateralization of the EEG theta band in a sample of dyslexic children. To this aim, a paradigm based on word-pair visual presentation was used in which the same words were processed in Semantic a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.06.009
更新日期:2006-01-01 00:00:00
abstract::The primary visual cortex (V1) has been shown to be critical for visual awareness, but the importance of other low-level visual areas has remained unclear. To clarify the role of human cortical area V2 in visual awareness, we applied transcranial magnetic stimulation (TMS) over V2 while participants were carrying out ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2012.03.015
更新日期:2012-06-01 00:00:00
abstract::Forms of implicit memory, including repetition effects, are preserved relative to explicit memory in clinical Alzheimer's disease. Consequently, cognitive interventions for persons with Alzheimer's disease have been developed that leverage this fact. However, despite the clinical robustness of behavioral repetition ef...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.05.001
更新日期:2018-08-01 00:00:00
abstract::Previous research suggests that action video game play improves attentional resources, allowing gamers to better allocate their attention across both space and time. In order to further characterize the plastic changes resulting from playing these video games, we administered the Attentional Network Test (ANT) to acti...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.02.002
更新日期:2009-07-01 00:00:00
abstract::We localized the neuroanatomical correlates for control of saccadic eye movements and for finger movements using a combined transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) approach. Two participants underwent TMS while performing an endogenous saccade task. The motor hand area was localize...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(98)00097-9
更新日期:1999-02-01 00:00:00
abstract:INTRODUCTION:Developmental dyslexia (DD) is a frequent language-based learning disorder. The predominant etiological view postulates that reading problems originate from a phonological impairment. METHOD:We studied mismatch negativity (MMN) and Late Discriminative Negativity (LDN) to syllables change in both children ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.12.010
更新日期:2009-02-01 00:00:00
abstract::The social communication impairments defining autism spectrum disorders (ASD) may be built upon core deficits in perspective-taking, language processing, and self-other representation. Self-referential processing entails the ability to incorporate self-awareness, self-judgment, and self-memory in information processin...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.06.008
更新日期:2017-07-28 00:00:00