Localization of the human frontal eye fields and motor hand area with transcranial magnetic stimulation and magnetic resonance imaging.

Abstract:

:We localized the neuroanatomical correlates for control of saccadic eye movements and for finger movements using a combined transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) approach. Two participants underwent TMS while performing an endogenous saccade task. The motor hand area was localized by TMS and the region anterior to it was mapped to identify the borders of a region where TMS produced delays in generating contralateral saccades. MRI scans were then obtained with fiducial markers placed over the motor hand area and 2 cm anterior to it, the common cortical region that produced saccadic delays in these two subjects. It was also shown that the structural anatomy of the hand area, physiologically defined by visible contractions of the contralateral hand following TMS, corresponded to the knob-like structure recently reported [18, 19]. These results demonstrate that TMS can be a precise, non-invasive tool for neuroanatomical mapping of cortical structures when combined with structural images of the brain.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Ro T,Cheifet S,Ingle H,Shoup R,Rafal R

doi

10.1016/s0028-3932(98)00097-9

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

225-31

issue

2

eissn

0028-3932

issn

1873-3514

pii

S0028393298000979

journal_volume

37

pub_type

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