Left ventrolateral prefrontal cortex and the cognitive control of memory.

Abstract:

:Cognitive control mechanisms permit memory to be accessed strategically, and so aid in bringing knowledge to mind that is relevant to current goals and actions. In this review, we consider the contribution of left ventrolateral prefrontal cortex (VLPFC) to the cognitive control of memory. Reviewed evidence supports a two-process model of mnemonic control, supported by a double dissociation among rostral regions of left VLPFC. Specifically, anterior VLPFC (approximately BA 47; inferior frontal gyrus pars orbitalis) supports controlled access to stored conceptual representations, whereas mid-VLPFC (approximately BA 45; inferior frontal gyrus pars triangularis) supports a domain-general selection process that operates post-retrieval to resolve competition among active representations. We discuss the contribution of these control mechanisms across a range of mnemonic domains, including semantic retrieval, recollection of contextual details about past events, resolution of proactive interference in working memory, and task switching. Finally, we consider open directions for future research into left VLPFC function and the cognitive control of memory.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Badre D,Wagner AD

doi

10.1016/j.neuropsychologia.2007.06.015

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

2883-901

issue

13

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(07)00221-7

journal_volume

45

pub_type

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