Abstract:
:Mild cognitive impairment (MCI), defined as episodic memory impairment beyond what is expected in normal aging, is often associated with hippocampal atrophy (HA) and may represent incipient Alzheimer's disease. However, recent studies suggest that MCI is very heterogeneous and multiple etiologies likely exist. One possibility is small vessel cerebrovascular disease (CVD). Specifically, we hypothesized that white matter hyperintensities (WMH), an MRI marker for CVD, would lead to impairments in executive control processes critical for working memory that may, in turn, result in episodic memory impairment. To test this hypothesis, we examined a group of subjects clinically diagnosed with MCI and used MRI to further subcategorize individuals as either MCI with severe white matter hyperintensities (MCI-WMH) or MCI with severe hippocampal atrophy (MCI-HA). MCI-WMH, MCI-HA, and matched control subjects each performed a battery of working memory and episodic memory tasks. Results showed that MCI-HA and MCI-WMH were equally impaired on the episodic memory task relative to controls, but MCI-WMH were additionally impaired on tests tapping verbal and spatial working memory abilities and attentional control processes. These results suggest that CVD and hippocampal dysfunction are associated with distinct neuropsychological profiles. Although both syndromes are associated with episodic memory deficits, CVD is additionally associated with working memory and executive control deficits.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Nordahl CW,Ranganath C,Yonelinas AP,DeCarli C,Reed BR,Jagust WJdoi
10.1016/j.neuropsychologia.2005.01.003subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1688-97issue
11eissn
0028-3932issn
1873-3514pii
S0028-3932(05)00022-9journal_volume
43pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::The hippocampus has been proposed to play a critical role in memory through its unique ability to bind together the disparate elements of an experience. This hypothesis has been widely examined in rodents using a class of tasks known as "configural" or "non-linear", where outcomes are determined by specific combinatio...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2007.04.007
更新日期:2007-09-20 00:00:00
abstract::Using positron emission tomography (PET), we studied physiological changes in a patient with frontal lobe damage resulting from closed head injury by assessing his regional cerebral blood flow (rCBF) pattern relative to that of his uninjured monozygotic (MZ) cotwin and against normal variability between cotwins in 10 ...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/0028-3932(95)00147-6
更新日期:1996-07-01 00:00:00
abstract::In Experiment I normal subjects performed the classical clinical line-bisection task, and demonstrated a left-side underestimation. In Experiment II subjects maintained fixation upon a central position and adjusted a rod passing through this fixation point so that both extremities were judged equal. The left-side unde...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(85)90029-6
更新日期:1985-01-01 00:00:00
abstract::Since Japanese learn the multiplication tables by means of mnemonic rhymes called kuku, i.e., via the auditory-speaking route, it is hypothesized that aphasics who have a deficit in kuku might relearn it via the visual-writing route. After having ordinary language therapy for more than 3 months, eight patients were ad...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(87)90032-7
更新日期:1987-01-01 00:00:00
abstract::Several models have proposed that different regions of the medial temporal lobes contribute to different aspects of episodic memory. For instance, according to one view, the perirhinal cortex represents specific items, parahippocampal cortex represents information regarding the context in which these items were encoun...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.02.011
更新日期:2013-10-01 00:00:00
abstract::Patients with visual field disorders often exhibit impairments in visual exploration and a typical defective oculomotor scanning behaviour. Recent evidence [Bolognini, N., Rasi, F., Coccia, M., & Làdavas, E. (2005b). Visual search improvement in hemianopic patients after audio-visual stimulation. Brain, 128, 2830-2842...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.10.008
更新日期:2009-01-01 00:00:00
abstract::The serial reaction time (SRT) task has been frequently used to assess procedural learning of sequences. Patients with Parkinson's disease (PD) have been reported to show deficits on this task, but it is as yet unclear whether this impairment reflects a general sequencing deficit or a deficit in the sequencing of moto...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(00)00059-2
更新日期:2000-01-01 00:00:00
abstract::The effects of optokinetic stimulation on position sense disorders were investigated in a series of 30 patients with unilateral vascular lesions (10 right brain-damaged patients with visuospatial hemineglect, 10 right brain-damaged patients without visuo-spatial hemineglect, 10 left brain-damaged patients), and 10 con...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(93)90067-a
更新日期:1993-11-01 00:00:00
abstract::Psychophysiological evidence supports a music-language association, such that experience in one domain can impact processing required in the other domain. We investigated the bidirectionality of this association by measuring event-related potentials (ERPs) in native English-speaking musicians, native tone language (Ca...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.03.019
更新日期:2015-05-01 00:00:00
abstract::The properties of errors made by normals and unilateral brain damaged patients in localizing points in each half of a plane have been further investigated. A lesion of either hemisphere affects specifically the performance in the left half of the plane, where controls attain the highest degree of constancy. Considerat...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(83)90028-3
更新日期:1983-01-01 00:00:00
abstract::Recent studies with multiple sclerosis (MS) participants have provided evidence for cortical reorganization. Greater recruitment of task-related areas and additional brain regions are thought to play an adaptive role in the performance of cognitive tasks. In this study, we compared cortical circuitry recruited by MS p...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.05.027
更新日期:2008-10-01 00:00:00
abstract::A growing body of evidence suggests that the amygdala is central to handling the demands of complex social life in primates. In this paper, we synthesize extant anatomical and functional data from rodents, monkeys, and humans to describe the topography of three partially distinct large-scale brain networks anchored in...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2014.08.013
更新日期:2014-10-01 00:00:00
abstract::The magnitude dimensions of number, time and space have been suggested to share some common magnitude processing, which may imply symmetric interaction among dimensions. Here we challenge these suggestions by presenting a double dissociation between two neuropsychological patients with left (JT) and right (CB) parieta...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.07.014
更新日期:2011-09-01 00:00:00
abstract::Neuroimaging evidence suggests that the parietal lobe has an important role in memory retrieval, yet neuropsychology is largely silent on this topic. Recently, we reported that unilateral parietal lobe damage impairs various forms of visual working memory when tested by old/new recognition. Here, we investigate whethe...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.03.005
更新日期:2008-01-01 00:00:00
abstract::A well-documented feature of Huntington's disease (HD) is disproportionate impairment in the ability to recognise the emotional expression of disgust. However, this finding has been challenged by studies that report no differential disgust impairment and attribute apparent differences across emotions to task difficult...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.04.018
更新日期:2008-09-01 00:00:00
abstract::Benton's test of Stereognosis was administered separately to the left and right hands of six patients with complete cerebral commissurotomy and two patients with partial commissurotomy sparing the splenium. Experiment 1 displayed the multiple choice card in free vision for all patients whereas Experiment 2 displayed i...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(98)00057-8
更新日期:1998-10-01 00:00:00
abstract::Visuomotor deficits in parietal patients suffering from Optic Ataxia (OA) have been so far studied during natural reaching movements. We aimed at understanding if these disorders are also present when more abstract visuomotor transformations are involved. A patient with unilateral OA was tested during both standard re...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.07.029
更新日期:2014-10-01 00:00:00
abstract::Auditory speech perception, speech production and reading lateralize to the left hemisphere in the majority of healthy right-handers. In this study, we investigated to what extent sensory input underlies the side of language dominance. We measured the lateralization of the three core subprocesses of language in patien...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.10.032
更新日期:2016-12-01 00:00:00
abstract::The hippocampus plays a critical role in verbal and spatial memory, thus any pathological damage to this formation may lead to cognitive impairment. It is suggested that right and left hippocampi are affected differentially in healthy or pathologic aging. The purpose of this study was to test the hypothesis that verba...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2016.08.016
更新日期:2016-12-01 00:00:00
abstract::This experiment investigated whether Parkinson's disease (PD) patients experience problems in producing stroke size, stroke duration or both, in a handwriting task. Thirteen PD patients and 15 elderly controls wrote four patterns of varying complexity on a digitizer tablet. The participants were instructed to execute ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(98)00122-5
更新日期:1999-06-01 00:00:00
abstract::This study investigated semantic priming for literal (stinging-mosquito) and metaphoric (stinging-insult) associates presented to either the left or right visual fields (RVF/LVF) across stimulus-onset-asynchronies (SOA) of 200 and 800 ms. For the short SOA condition, facilitation was found for metaphorically related t...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(97)00141-3
更新日期:1998-07-01 00:00:00
abstract::The belief-bias effect in syllogistic reasoning refers to the tendency for subjects to be erroneously biased when logical conclusions are incongruent with belief about the world. This study examined the role of inferior frontal cortex (IFC) in belief-bias reasoning using repetitive transcranial magnetic stimulation (r...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2010.03.021
更新日期:2010-06-01 00:00:00
abstract::The representation of semantic codes in the cerebral hemispheres and the interhemispheric communication of these codes, was investigated in two priming experiments where prime and target words were independently projected to the left or right visual fields (LVF or RVF). Nonassociated category exemplars were employed a...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/0028-3932(95)00144-1
更新日期:1996-05-01 00:00:00
abstract::Inhibition of return (IOR) is the name that is associated with a response time (RT) delay to a visual stimulus presented at a recently cued spatial location. Two experiments with 26 undergraduates used an auditory analog to the visual IOR paradigm to examine whether manual RT inhibition would occur in the absence of v...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(96)00015-2
更新日期:1996-10-01 00:00:00
abstract::Verbal short-term memory (VSTM) is thought to play a critical role in language learning. It is indexed by the nonword repetition task where listeners are asked to repeat meaningless words like 'blonterstaping'. The present study investigated the effect on nonword repetition performance of differences in efficiency of ...
journal_title:Neuropsychologia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuropsychologia.2011.09.018
更新日期:2011-11-01 00:00:00
abstract::Visual motion processing is often attributed to the dorsal visual pathway despite visual motion's involvement in almost all visual functions. Furthermore, some visual motion tasks critically depend on the structural integrity of regions outside the dorsal pathway. Here, based on numerous studies, I propose that visual...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2016.07.018
更新日期:2016-08-01 00:00:00
abstract::Using a whole report-paradigm based on [Bundesen, C. (1990). A theory of visual attention. Psychological Review, 97, 523-547; Bundesen, C. (1998). A computational theory of visual attention. Philosophical Transactions of the Royal Society of London B, Biological Sciences, 353, 1271-1281] theory of visual attention (TV...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2007.06.006
更新日期:2007-11-05 00:00:00
abstract::In a recent theoretical paper (Behavioral and Brain Sciences, 1990, 13, 519-542), Previc argued that vertical asymmetries in perception may largely result from the biases of the lower and upper visual fields toward proximal and distal space, respectively. The present study examined whether this same relationship may e...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/s0028-3932(97)00091-2
更新日期:1997-12-01 00:00:00
abstract::There is a conflicting literature on facial emotion processing in autism spectrum disorder (ASD): both typical and atypical performance have been reported, and inconsistencies in the literature may stem from different processes examined (emotion judgment, face perception, fixations) as well as differences in participa...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.03.024
更新日期:2017-05-01 00:00:00
abstract::Accurate perception of the emotional content of vocalisations is essential for successful social communication and interaction. However, it is not clear whether our ability to perceive emotional cues from vocal signals is specific to human signals, or can be applied to other species' vocalisations. Here, we address th...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.01.026
更新日期:2018-03-01 00:00:00