Abstract：
INTRODUCTION:Developmental dyslexia (DD) is a frequent language-based learning disorder. The predominant etiological view postulates that reading problems originate from a phonological impairment. METHOD:We studied mismatch negativity (MMN) and Late Discriminative Negativity (LDN) to syllables change in both children (n=12; 8-12 years) and young adults (n=15; 14-23 years) with DD compared with controls. RESULTS/DISCUSSION:The present study confirmed abnormal automatic discrimination of syllable changes in both children and adults with developmental dyslexia. MMN topographic, amplitude and latency group differences were evidenced, suggesting different brain mechanisms involved in elementary auditory stimulus change-detection in DD, especially in the left hemisphere. The LDN results demonstrated that the auditory disorder of temporal processing in DD children becomes more serious at late stages of information processing and that the apparent cerebral hypo reactivity to speech changes in DD actually may correspond to additional processes. The age-related differences observed in both MMN and LDN topographies, amplitudes and latency between subjects with DD and controls could indicate different developmental courses in the neural representation of basic speech sounds in good and poor readers, with a tendency to normalization with increasing age. CONCLUSION:Our results showing atypical electrophysiological concomitants of speech auditory perception in DD strongly support the hypothesis of deviant cortical organization in DD.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Hommet C,Vidal J,Roux S,Blanc R,Barthez MA,De Becque B,Barthelemy C,Bruneau N,Gomot Mdoi
10.1016/j.neuropsychologia.2008.12.010subject
Has Abstractpub_date
2009-02-01 00:00:00pages
761-70issue
3eissn
0028-3932issn
1873-3514pii
S0028-3932(08)00477-6journal_volume
47pub_type
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