Abstract：
:The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the field of cancer immunotherapy. Currently, there is a wide variety of immunotherapeutic approaches and critical improvements are continually being made. Among different immunotherapeutic strategies, therapies based on the blockade of immune checkpoint molecules have shown unparalleled efficacy in late-stage cancer patients. Pre-clinical research using ex vivo and in vivo approaches demonstrates the promise of numerous novel strategies for the immunotherapy of cancer.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Rusch T,Bayry J,Werner J,Shevchenko I,Bazhin AVdoi
10.1007/s00005-017-0491-5subject
Has Abstractpub_date
2018-04-01 00:00:00pages
89-96issue
2eissn
0004-069Xissn
1661-4917pii
10.1007/s00005-017-0491-5journal_volume
66pub_type
杂志文章,评审abstract：:Recent data have demonstrated that presence of apolipoprotein E (APOE) epsilon *4 allele is a major risk factor of Alzheimer's disease (AD). We determined the APOE genotypes in 64 patients with sporadic probable AD and 43 non-demented aged controls selected from Poznań region and the western part of Poland using the p...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The ability of retinoic acid to inhibit the growth of three human melanoma cell lines (MEW18, MEW22, MEW81) was studied in culture. The exposure of the cell lines to different concentrations of RA resulted in an inhibition of the cell growth, dependent on the quantity of RA in the medium. Effects on cell growth of MEW...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The purpose of this study is to evaluate the relationship between the concentration of interleukin-8 (IL-8) in exhaled breath condensate (EBC) and bronchoalveolar lavage fluid (BALF) with the disease activity score and pulmonary function of systemic lupus erythematosus (SLE) patients with and without pulmonary fibrosi...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-014-0270-5
更新日期：2014-06-01 00:00:00
abstract：:Fourteen patients with chronic renal failure and their prospective living donors were examined. DNA uptake by donors' monocultures, recipients' monocultures and mixed cultures was measured. The influence of X-ray treated cells on proliferative capacity of untreated cells in these three types of cultures was studied. T...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Using a Technicon autoanalyzer method of Marsh 752 sera of patients, Rh-negative subjects in the initial stage of immunization with Rh-positive blood, and healthy blood donors were investigated. In 56 sera (8.7%) positive reactions with standard erythrocytes were found. In 21 of these cases (36%) specificity of antibo...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease that has a considerable impact on the quality of life. Alterations in signalling pathways may contribute to the ongoing inflammation and proliferation in CRSwNP. The MEK1/2-ERK1/2 pathway transmits signals from many extracellular molecules to regula...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-014-0281-2
更新日期：2014-06-01 00:00:00
abstract：:Total number of mast cells in popliteal lymph nodes of Balb/c mice is a function of time and Nu gene (complex?) content. The number of mast cells increases with age - in both wild +/+ and in Nu gene (complex?) carriers (Nu/+ and Nu/Nu). The increase in the number of mast cells is faster in the Nu gene carriers than in...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：INTRODUCTION:Rheumatism has been treated using whole-body cryotherapy (WBCT) since the 1970s. The aim of this study was to assess the efficacy of WBCT as an experimental, adjunctive method of treating depressive and anxiety disorders. MATERIALS AND METHODS:A control (n=34) and a study group (n=26), both consisting of ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-008-0006-5
更新日期：2008-01-01 00:00:00
abstract：:Immunofiltration technique with polyclonal and monoclonal antibodies for semi-quantitative assays of human albumin, chorionic gonadotropin, immunoglobulin G and transferrin was elaborated. An amount of antibody was immobolized in the form of 6 radially located small bars on a dry test filter made of glass microfibre s...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Studies performed on chimpanzees and humans have revealed that strong, multispecific and sustained CD4(+) and CD8(+) T cell immune responses is a major determinant of hepatitis C virus (HCV) clearance. However, spontaneous elimination of the virus occurs in minority of infected individuals and cellular response direct...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-015-0364-8
更新日期：2016-04-01 00:00:00
abstract：:In order to determine the frequency of HIV antibodies among patients with haemophilia and other inheritable blood clotting disorder in the Lower Silesia region of South-West Poland, we examined a representative fraction comprising 106 patients from a cohort of 302 blood clotting disorder patients. The methods used for...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Understanding the homeostatic mechanisms governing lymphocyte pools achieves critical importance as lymphocyte-targeted therapies expand in use and scope. The primacy of B lymphocyte stimulator (BLyS) family ligands and receptors in governing B lymphocyte homeostasis has become increasingly clear in recent years, affo...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-008-0017-2
更新日期：2008-05-01 00:00:00
abstract：:C3H mice after transplantation of solid Gardner lymphosarcoma were injected with Methotrexate (MTX) or Alexan. The prolonged survival time of mice treated with antimetabolites was in some cases evidently reduced after an additional injection of Corynebacterium parvum (C.p.). This reduction did not depend on the sequen...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Decalcified rat bone matrix or sequentially treated rat bone gelatin, as well as dog transitional epithelium when implanted intramuscularly in mice induce cartilage, bone and bone marrow formation. Heterotopic bone induction is markedly reduced or abolished when animals are irradiated prior to implantation of decalcif...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Production of interleukin 12 (IL-12) during cytotoxic reaction of C57BL/6 and BALB/c spleen lymphocytes or their subpopulations: T+B, T, CD4+ and CD8+ cells to L. innocua-phagocyting syngeneic macrophages was examined. The effector cell donors were untreated or L. innocua-infected. The number of surviving bacteria in ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Determinations of the blood serum levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and their soluble receptors (sIL-6R, sTNFR) in denture stomatitis patients (DS) were performed. Serum levels of interleukins and their soluble receptors were measured using the ELISA method. In all examined patien...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:The activity of neutral glucoamylase and alpha-amylase were determined in the myocardium and skeletal muscle after in vivo pharmacologic stimulation of adrenergic receptors. The activity changes of these enzymes were found to not always occur parallelly. The activity of both these enzymes is decreased under beta-agoni...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The comparison of electrophoretic protein patterns and concentrations of the G, A and M immunoglobulins before initiation of oral IFN-alpha therapy of viral hepatitis and after 2 weeks of treatment allow to predict patient's response. Patient who after 2 weeks of treatment with ultra-low orally administered IFN-alpha ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Appropriate combinations of immunotherapy and gene therapy promise to be more effective in the treatment of cancer patients than either of these therapeutic approaches alone. One such treatment is based on the application of patients' cytotoxic T cells, which can be activated, expanded, and genetically engineered to r...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-010-0091-0
更新日期：2010-10-01 00:00:00
abstract：:We measured the soluble IL-2 receptor alpha (sIL-2R alpha) in sera and in bone marrow of 20 patients with minimal residual hematological malignances, 6 of them with multiple myeloma (MM), 8 with Hodgkin's disease (HD) and 6 with non-Hodgkin's lymphoma (NHL), low grade. Compared to 10 normal individuals, HD and NHL gro...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Our studies on the syngeneic immunization with normal cells did not confirm the possibility of induction of alloreactive cytotoxic antibodies in this way. We were not able to induce any antibodies after syngeneic immunizations within BALB/c and BALB/cfC3H strains of mice. Anti-H-2 cytotoxic antibodies were raised by s...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal Ig...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-020-00572-8
更新日期：2020-04-20 00:00:00
abstract：INTRODUCTION:The objective of the study was to assess the relationship between Chlamydia trachomatis (C.t.) infection of the prostate and the concentration of citric acid. MATERIALS AND METHODS:The study involved 60 patients with chronic prostatitis (NIH III). Urethral swabs and expressed prostatic secretions (EPS) we...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-006-0009-z
更新日期：2006-01-01 00:00:00
abstract：:Biological effects of conjugates of quinone derivatives with antibodies were studied. Two methods of conjugation of aziridine derivatives of quinone with anti-L-1210 antibodies were used: the direct substitution of the protein amino groups or thiolation of immunoglobulins and subsequent substitution of the sulfhydryl ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Use of a four-step method of purification from human kidneys yielded gamma-glutamyl transpeptidase with specific activity 330 times higher than activity in the homogenate. The enzyme from human liver was also purified, and from urine two fractions of it were separated. From rabbits immunized with the enzyme from human...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:The effects of the mixtures of human, porcine and murine interferons (IFNs) alpha, beta and gamma and bovine IFN-alpha were studied in human, porcine and murine cells. The synergistic action of the mixtures of IFN-alpha/beta and IFN-gamma occurred not only in the homologous but also in the heterologous systems. The sy...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Ecothiopate (Etp), 10 mug injected into the lateral cerebral ventricle (ivtr), diminished spontaneous motility and open-field performance, lowered body temperature, inhibited amphetamine-induced hypermotility and stereotypy, prolonged hexobarbital anesthesia and did not induce catalepsy. These behavioral symptoms were...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:The production of sheep Pseudomonas immune serum is described. The animals were immunized with Pseudomonas vaccine prepared from strains of Pseudomonas aeruginosa belonging to seven immunotypes of Fisher's schema. Immune sera obtained from hyperimmunized sheep are characterized by a high level of stabel antibodies wit...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesen...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-017-0493-3
更新日期：2018-08-01 00:00:00
abstract：:Umbilical cord blood transplantation (UCBT) is known to be associated with increased risk of infections, compared to bone marrow or peripheral blood stem cell transplantation. In viral diseases for which specific treatment is available, real-time PCR assays are reliable diagnostic tools for timely initiation of approp...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-010-0096-8
更新日期：2010-12-01 00:00:00
