Apolipoprotein E genotypes in sporadic early and late-onset Alzheimer's disease.

Abstract:

:Recent data have demonstrated that presence of apolipoprotein E (APOE) epsilon *4 allele is a major risk factor of Alzheimer's disease (AD). We determined the APOE genotypes in 64 patients with sporadic probable AD and 43 non-demented aged controls selected from Poznań region and the western part of Poland using the polymerase chain reaction (PCR) followed by the restriction fragment length polymorphism (RFLP) analysis. We confirmed a strong correlation of the APOE epsilon *4 allele with sporadic late-onset AD. In contrast to many previous reports we did not found an association between the APOE epsilon *4 allele and sporadic early-onset AD.

authors

Kowalska A,Florczak J,Pruchnik-Wolińska D,Kraszewski A,Wender M

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

177-81

issue

3

eissn

0004-069X

issn

1661-4917

journal_volume

46

pub_type

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