Abstract：
:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease that has a considerable impact on the quality of life. Alterations in signalling pathways may contribute to the ongoing inflammation and proliferation in CRSwNP. The MEK1/2-ERK1/2 pathway transmits signals from many extracellular molecules to regulate cellular processes. We examined tissue samples from nasal polyps and the inferior turbinate of patients with CRSwNP and the inferior turbinate from subjects with healthy mucosa. The expressions of MEK1/2, ERK1/2, and their active phosphorylated forms pMEK1/2 and pERK1/2 were analysed using DNA microarray, quantitative real-time PCR, protein array, Western hybridisation, and immunohistochemistry. We detected increased MEK1/2 protein expression in nasal polyps compared to the inferior turbinates of patients with CRSwNP or healthy mucosa. We also found a higher amount of MEK1/2 in the inferior turbinates of patients with CRSwNP compared to those with healthy mucosa. Most importantly, we observed a significant increase in the phosphorylation of MEK1/2 and ERK1/2 in nasal polyps compared to both types of controls. We observed activation of the MEK1/2-ERK1/2 pathway in nasal polyps. Interestingly, we did not see the same activation pattern in different tiers of the MEK1/2-ERK1/2 signalling cascade. One explanation for this result is that the components enhance the complex MEK-ERK cascade in a distinct manner, enabling a wide variety of functions. The MEK1/2-ERK1/2 pathway appears to play a pivotal role in the pathogenesis of CRSwNP.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Linke R,Pries R,Könnecke M,Bruchhage KL,Böscke R,Gebhard M,Wollenberg Bdoi
10.1007/s00005-014-0281-2subject
Has Abstractpub_date
2014-06-01 00:00:00pages
217-29issue
3eissn
0004-069Xissn
1661-4917journal_volume
62pub_type
杂志文章abstract：:Allogenic transplantations of bone marrow or spleen cells were carried out on rabbits treated with cyclophosphamide. About 50% of the recipients developed chimerism of peripheral blood cells. Chimerism was a passing phenomenon prevailing from 14 to 180 days after grafting. A phenomenon indicating that not all cell lin...
journal_title：Archivum immunologiae et therapiae experimentalis
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doi：
更新日期：1978-01-01 00:00:00
abstract：:Reactivity of OK-CLL monoclonal antibodies that can identify CD5 antigen on peripheral blood mononuclear cells, was investigated in 172 patients with B cell chronic lymphocytic leukemia (B-CLL) in clinical stages RAI O-I and RAI II-IV and in patients with non-Hodgkin's lymphomas, classified according to the Working fo...
journal_title：Archivum immunologiae et therapiae experimentalis
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更新日期：1995-01-01 00:00:00
abstract：:The present paper discusses the correlation between NDV-induced interferon production and the degree of histamine release from mouse mastocytes. The injection of mice with Newcastle virus was observed to substantially increase the percentage of released histamine and the degree of mastocytes degranulation. A clear-cut...
journal_title：Archivum immunologiae et therapiae experimentalis
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更新日期：1984-01-01 00:00:00
abstract：:Adjuvant-induced arthritis in rats is a chronic inflammatory disease, widely used as an animal model for rheumatoid arthritis. In our study the effect of various fractions of dialyzable leukocyte extract (DLE): DLE I-molecular weight below 10 kDa (commercial preparation), DLE II-molecular weight below 5 kDa (suppresso...
journal_title：Archivum immunologiae et therapiae experimentalis
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更新日期：1994-01-01 00:00:00
abstract：:Recent studies have shown marked geographic variation associated with Epstein-Barr virus (EBV) in pediatric Burkitt's lymphomas and Hodgkin's disease. In the present study we investigated 30 cases of pediatric extranodal high grade non-Hodgkin's lymphomas (NHL) from Turkey with an abdominal localisation. To classify t...
journal_title：Archivum immunologiae et therapiae experimentalis
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journal_title：Archivum immunologiae et therapiae experimentalis
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journal_title：Archivum immunologiae et therapiae experimentalis
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The carbohydrate and amino acid compositions of the purified Fc receptor from human placental trophoblasts are described. The placental receptor is a glycoprotein. The total content of carbohydrates in the receptor is 30% (w/w). The major carbohydrate components are galactose, N-acetylglucosamine, fucose, and mannose....
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-012-0206-x
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
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doi：
更新日期：1995-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
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doi：
更新日期：1983-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
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更新日期：2005-07-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-016-0423-9
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journal_title：Archivum immunologiae et therapiae experimentalis
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doi：10.1007/s00005-016-0440-8
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
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journal_title：Archivum immunologiae et therapiae experimentalis
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journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
