A rabbit used as a model for testing hematopoietic tissue transplants.

Abstract:

:Allogenic transplantations of bone marrow or spleen cells were carried out on rabbits treated with cyclophosphamide. About 50% of the recipients developed chimerism of peripheral blood cells. Chimerism was a passing phenomenon prevailing from 14 to 180 days after grafting. A phenomenon indicating that not all cell lines develop after transplantation from the donor stem cells, was observed. This phenomenon has been called "restricted chimerism". The GvH reaction was of a chronic type. Relative spleen weights were significantly increased in animals receiving the spleen cell grafts, but not in animals receiving bone marrow grafts. A direct positive erythrocyte Coombs test was found in almost all graft recipients. In addition cytotoxic autoantibodies against lymphocytes were present in sera of about 20% of the recipients.

authors

Kosiński S,Matej H

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

1021-5

issue

1-6

eissn

0004-069X

issn

1661-4917

journal_volume

26

pub_type

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