Abstract:
:We report the case of a 14-year-old girl suffering from severe developmental visual impairment along with delayed language and cognitive development, and featuring a clear-cut dissociation between spared dorsal and impaired ventral visual pathways. Visual recognition of objects, including faces and printed words, was affected. In contrast, movement perception and visually guided motor control were preserved. Structural MRI was normal on inspection, but Voxel Based Morphometry (VBM) revealed reduced grey matter density in the mesial occipital and ventral occipito-temporal cortex. Functional MRI during the perception of line drawings uncovered impaired differentiation which is normally observed at even younger ages: no local category preferences could be identified within the occipito-temporal cortex for faces, houses, words or tools. In contrast, movement-related activations appeared to be normal. Finally, those abnormalities evolved on the background of chronic bilateral occipital epileptic activity, including continuous spike-wave discharges during sleep, which may be considered as the primary cause of non-specific intellectual disability and visual impairment.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Martinaud O,Pouliquen D,Parain D,Goldenberg A,Gérardin E,Hannequin D,Altarelli I,Ramus F,Hertz-Pannier L,Dehaene-Lambertz G,Cohen Ldoi
10.1016/j.neuropsychologia.2015.08.009subject
Has Abstractpub_date
2015-10-01 00:00:00pages
52-61eissn
0028-3932issn
1873-3514pii
S0028-3932(15)30125-1journal_volume
77pub_type
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