Vision and cognition in Alzheimer's disease.

Abstract:

:Alzheimer's disease (AD) is known to affect visual pathways, but potential concomitant effects on vision and cognitive performance are not well understood. We studied 43 individuals with AD of mild severity and 22 individuals without dementia on a battery of tests designed to measure multiple aspects of basic and higher-order visual perception and cognition. All subjects performed on the same visual and cognitive test batteries. The results showed no differences between groups on tests of static visual acuity, stereoacuity, dynamic visual acuity or motion direction discrimination. However, individuals with AD performed significantly worse on tests of static spatial contrast sensitivity, visual attention, shape-from-motion, color, visuospatial construction and visual memory. Correlation analyses showed strong relationships between visual and cognitive scores. The findings show that AD affects several aspects of vision and are compatible with the hypothesis that visual dysfunction in AD may contribute to performance decrements in other cognitive domains. The pattern of involvement indicates that AD affects multiple visual neural pathways and regions. It is possible that better understanding of vision-related dysfunction could aid diagnosis and interventions to improve functional capacity in patients with dementia.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Rizzo M,Anderson SW,Dawson J,Nawrot M

doi

10.1016/s0028-3932(00)00023-3

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

1157-69

issue

8

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(00)00023-3

journal_volume

38

pub_type

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