Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysis.

Abstract:

:Broca's area in the inferior frontal gyrus consists of two cytoarchitectonically defined regions-Brodmann areas (BA) 44 and 45. Combining probabilistic maps of these two areas with functional neuroimaging data obtained using PET, it is shown that BA45, not BA44, is activated by both speech and signing during the production of language narratives in bilingual subjects fluent from early childhood in both American Sign Language (ASL) and English when the generation of complex movements and sounds is taken into account. It is BA44, not BA45, that is activated by the generation of complex articulatory movements of oral/laryngeal or limb musculature. The same patterns of activation are found for oral language production in a group of English speaking monolingual subjects. These findings implicate BA45 as the part of Broca's area that is fundamental to the modality-independent aspects of language generation.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Horwitz B,Amunts K,Bhattacharyya R,Patkin D,Jeffries K,Zilles K,Braun AR

doi

10.1016/s0028-3932(03)00125-8

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1868-76

issue

14

eissn

0028-3932

issn

1873-3514

pii

S0028393203001258

journal_volume

41

pub_type

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