Abstract：
:This study investigated the impact of Alzheimer׳s disease (AD) on conjunctive and relational binding in episodic memory. Mild AD patients and controls had to remember item-color associations by imagining color either as a contextual association (relational memory) or as a feature of the item to be encoded (conjunctive memory). Patients׳ performance in each condition was correlated with cerebral metabolism measured by FDG-PET. The results showed that AD patients had an impaired capacity to remember item-color associations, with deficits in both relational and conjunctive memory. However, performance in the two kinds of associative memory varied independently across patients. Partial Least Square analyses revealed that poor conjunctive memory was related to hypometabolism in an anterior temporal-posterior fusiform brain network, whereas relational memory correlated with metabolism in regions of the default mode network. These findings support the hypothesis of distinct neural systems specialized in different types of associative memory and point to heterogeneous profiles of memory alteration in Alzheimer׳s disease as a function of damage to the respective neural networks.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Bastin C,Bahri MA,Miévis F,Lemaire C,Collette F,Genon S,Simon J,Guillaume B,Diana RA,Yonelinas AP,Salmon Edoi
10.1016/j.neuropsychologia.2014.08.023subject
Has Abstractpub_date
2014-10-01 00:00:00pages
99-106eissn
0028-3932issn
1873-3514pii
S0028-3932(14)00286-3journal_volume
63pub_type
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