Automatic semantic priming of nouns and verbs in patients with Alzheimer's disease.

Abstract:

:The status of semantic representations of nouns (concrete and abstract) and verbs (motion and non-motion) was investigated in patients with Alzheimer's disease (AD). Nouns and verbs have been argued to activate different neural substrates, given the selective difficulties reported for one or the other grammatical class in patients with focal lesions. Additionally, category-specific deficits have been reported for either abstract or concrete words, often in patients with bilateral neuropathology. We looked for these types of dissociations in patients with AD in a semantic priming experiment using a pronunciation task and a short stimulus onset asynchrony. The normal control subjects demonstrated automatic activation for both concrete nouns and motion verbs. The AD patients, however, demonstrated priming effects for concrete nouns, but not for motion verbs. This dissociation between concrete nouns and motion verbs found for the AD patients is discussed in terms of differences in the nature of semantic representations involving multiple physical and functional attributes in the case of concrete nouns, but only motion attributes in the case of motion verbs. Moreover, the typical distribution of neuropathology associated with AD may put motion verbs at risk, particularly given the neuroanatomical considerations suggested by recent positron emission tomography (PET) studies.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Bushell CM,Martin A

doi

10.1016/s0028-3932(97)00046-8

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

1059-67

issue

8

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(97)00046-8

journal_volume

35

pub_type

杂志文章
  • Superior haptic-to-visual shape matching in autism spectrum disorders.

    abstract::A weak central coherence theory in autism spectrum disorder (ASD) proposes that a cognitive bias toward local processing in ASD derives from a weakness in integrating local elements into a coherent whole. Using this theory, we hypothesized that shape perception through active touch, which requires sequential integrati...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2011.12.024

    authors: Nakano T,Kato N,Kitazawa S

    更新日期:2012-04-01 00:00:00

  • Direct evidence for differential roles of temporal and frontal components of auditory change detection.

    abstract::Automatic change detection is a fundamental capacity of the human brain. In audition, this capacity is indexed by the mismatch negativity (MMN) event-related potential, which is putatively supported by a network consisting of superior temporal and frontal nodes. The aim of this study was to elucidate the roles of thes...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2006.11.023

    authors: Shalgi S,Deouell LY

    更新日期:2007-04-09 00:00:00

  • Eye-blink rate predicts individual differences in pseudoneglect.

    abstract::Most healthy individuals display a subtle spatial attentional bias, exhibiting relative inattention for stimuli on one side of the visual field, a phenomenon known as pseudoneglect. Prior work in animals and patients has implicated dopamine in spatial attention asymmetries. The current study therefore examined - in he...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2009.12.027

    authors: Slagter HA,Davidson RJ,Tomer R

    更新日期:2010-04-01 00:00:00

  • Higher intraindividual variability is associated with more forgetting and dedifferentiated memory functions in old age.

    abstract::Intraindividual trial-to-trial reaction time (RT) variability is commonly found to be higher in clinical populations or life periods that are associated with impaired cognition. In the present study, higher within-person trial-to-trial RT variability in a perceptual speed task is related to more forgetting and dediffe...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2011.03.013

    authors: Papenberg G,Bäckman L,Chicherio C,Nagel IE,Heekeren HR,Lindenberger U,Li SC

    更新日期:2011-06-01 00:00:00

  • Processing of auditory spatial cues in human cortex: an fMRI study.

    abstract::The issue of where in the human cortex coding of sound location is represented still is a matter of debate. It is unclear whether there are cortical areas that are specifically activated depending on the location of sound. Are identical or distinct cortical areas in one hemisphere involved in processing of sounds from...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2005.05.021

    authors: Zimmer U,Lewald J,Erb M,Karnath HO

    更新日期:2006-01-01 00:00:00

  • An investigation of naming errors following semantic and phonemic cueing.

    abstract::This study investigated the types of verbal errors produced by aphasic patients following phonemic and semantic cueing. Twenty-eight aphasic patients--10 Broca's, 10 Wernicke's and 8 conduction aphasics--served as subjects. Semantic and phonemic cues were administered on object and action confrontation-naming tasks. W...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(91)90078-m

    authors: Li EC,Williams SE

    更新日期:1991-01-01 00:00:00

  • Cerebellar and prefrontal-cortical engagement during higher-order rule learning in older adulthood.

    abstract::To date most aging research has focused on cortical systems and networks, ignoring the cerebellum which has been implicated in both cognitive and motor function. Critically, older adults (OA) show marked differences in cerebellar volume and functional networks, suggesting it may play a key role in the behavioral diffe...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2020.107620

    authors: Jackson TB,Maldonado T,Eakin SM,Orr JM,Bernard JA

    更新日期:2020-11-01 00:00:00

  • Selective disturbance of mental rotation by cortical stimulation.

    abstract::In order to plan activity, people must imagine the spatial consequences of potential actions. Two classes of mental spatial transformation can be distinguished: Object-based spatial transformations are imagined movements of objects, such as mental rotation. Egocentric perspective transformations are imagined changes i...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(03)00099-x

    authors: Zacks JM,Gilliam F,Ojemann JG

    更新日期:2003-01-01 00:00:00

  • More than skin deep: body representation beyond primary somatosensory cortex.

    abstract::The neural circuits underlying initial sensory processing of somatic information are relatively well understood. In contrast, the processes that go beyond primary somatosensation to create more abstract representations related to the body are less clear. In this review, we focus on two classes of higher-order processi...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropsychologia.2009.08.022

    authors: Longo MR,Azañón E,Haggard P

    更新日期:2010-02-01 00:00:00

  • Further evidence of an association between handedness and neuroanatomical asymmetries in the primary motor cortex of chimpanzees (Pan troglodytes).

    abstract::The neurobiology of handedness is still poorly understood in nonhuman primates. Recently, an association between hand preference and precentral gyrus morphology in chimpanzees was reported. The aim of this study was to further evaluate the association between handedness and asymmetries in the precentral gyrus of chimp...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2006.03.037

    authors: Dadda M,Cantalupo C,Hopkins WD

    更新日期:2006-01-01 00:00:00

  • Brain activation during dichotic presentations of consonant-vowel and musical instrument stimuli: a 15O-PET study.

    abstract::Dichotic listening means that two different stimuli are presented at the same time, one in each ear. This technique is frequently used in experimental and clinical studies as a measure of hemispheric specialization. The primary aim of the present study was to record regional changes in the distribution of cerebral blo...

    journal_title:Neuropsychologia

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0028-3932(98)00101-8

    authors: Hugdahl K,Brønnick K,Kyllingsbaek S,Law I,Gade A,Paulson OB

    更新日期:1999-04-01 00:00:00

  • Attention and interference in the processing of global and local information: effects of unilateral temporal-parietal junction lesions.

    abstract::The processing of hierarchical stimuli was examined in patients with lesions in the temporal-parietal junction. In separate blocks of trials, subjects were instructed to identify the letter at the local or the global level of a hierarchical stimulus. Consistent with previous findings, reaction times for controls were ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(89)90052-3

    authors: Lamb MR,Robertson LC,Knight RT

    更新日期:1989-01-01 00:00:00

  • Task-related and resting-state fMRI identify distinct networks that preferentially support remembering the past and imagining the future.

    abstract::The relation between episodic memory and episodic future thought (EFT) remains an active target of research. A growing literature suggests that similar cognitive processes and neural substrates tend to support these acts. However, direct comparisons of whole-brain activity reveal clear differences, with numerous regio...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2017.06.016

    authors: Gilmore AW,Nelson SM,Chen HY,McDermott KB

    更新日期:2018-02-01 00:00:00

  • Some correlates of intra- and interhemispheric speech organization after left focal brain injury.

    abstract::Determinants of inter- and intrahemispheric organization following left focal injury were examined with data deriving from four different studies that used three different assessment methods (amobarbital, temporal lobectomy, dichotic listening). With regard to interhemispheric reorganization, the results revealed that...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(88)90087-5

    authors: Satz P,Strauss E,Wada J,Orsini DL

    更新日期:1988-01-01 00:00:00

  • Reduced startle reflex and aversive noise perception in patients with orbitofrontal cortex lesions.

    abstract::In the present study, the primary emotional response represented by the acoustic startle reflex was investigated in a group of six male patients, selected with lesions of the orbitofrontal cortex, and twenty matched healthy controls. Accurate neuropsychological assessment and lesion mapping showed relatively spared co...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2007.10.018

    authors: Angrilli A,Bianchin M,Radaelli S,Bertagnoni G,Pertile M

    更新日期:2008-03-07 00:00:00

  • Modulation of mu suppression in children with autism spectrum disorders in response to familiar or unfamiliar stimuli: the mirror neuron hypothesis.

    abstract::In an early description of the mu rhythm, Gastaut and Bert [Gastaut, H. J., & Bert, J. (1954). EEG changes during cinematographic presentation. Clinical Neurophysiology, 6, 433-444] noted that it was blocked when an individual identified himself with an active person on the screen, suggesting that it may be modulated ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2008.01.010

    authors: Oberman LM,Ramachandran VS,Pineda JA

    更新日期:2008-04-01 00:00:00

  • Topographical memory impairments after unilateral lesions of the anterior thalamus and contralateral inferotemporal cortex.

    abstract::Monkeys with crossed unilateral excitotoxic lesions of the anterior thalamus and unilateral inferotemporal cortex ablation were severely impaired at learning two tasks which required the integration of information about the appearance of objects and their positions in space. The lesioned monkeys were also impaired at ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2004.02.005

    authors: Ridley RM,Baker HF,Mills DA,Green ME,Cummings RM

    更新日期:2004-01-01 00:00:00

  • The interaction between semantic and the nonsemantic systems in reading: Evidence from Chinese.

    abstract::We report a Chinese-speaking patient WJX with left temporal lobe ischemic damage resulting in dementia. Similar to English speaking patients with this pathology, WJX showed impaired semantic system functioning together with a well preserved ability to read aloud Chinese characters including characters with unpredictab...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2007.02.007

    authors: Bi Y,Han Z,Weekes B,Shu H

    更新日期:2007-09-20 00:00:00

  • Contralateral delay activity during temporal order memory.

    abstract::In everyday life, we constantly need to remember the temporal sequence of visual events over short periods of time, for example, when making sense of others' actions or watching a movie. While there is increasing knowledge available on neural mechanisms underlying visual working memory (VWM) regarding the identity and...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2019.03.012

    authors: Pomper U,Ditye T,Ansorge U

    更新日期:2019-06-01 00:00:00

  • Children's and adults' neural bases of verbal and nonverbal 'theory of mind'.

    abstract::Theory of mind (ToM) - our ability to predict behaviors of others in terms of their underlying intentions - has been examined through verbal and nonverbal false-belief (FB) tasks. Previous brain imaging studies of ToM in adults have implicated medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ) for adu...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2006.11.017

    authors: Kobayashi C,Glover GH,Temple E

    更新日期:2007-04-08 00:00:00

  • Cognitive estimation in patients with probable Alzheimer's disease and alcoholic Korsakoff patients.

    abstract::Cognitive estimation is an important function in daily living. In early studies it was proposed that estimation deficits are associated with frontal lobe damage and executive dysfunctions. In this study, we assessed Alzheimer patients and patients with alcoholic Korsakoff's syndrome with a newly developed cognitive es...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(02)00183-5

    authors: Brand M,Kalbe E,Fujiwara E,Huber M,Markowitsch HJ

    更新日期:2003-01-01 00:00:00

  • Crossmodal enhancement of visual orientation discrimination by looming sounds requires functional activation of primary visual areas: a case study.

    abstract::Approaching or looming sounds are salient, potentially threatening stimuli with particular impact on visual processing. The early crossmodal effects by looming sounds (Romei, Murray, Cappe, & Thut, 2009) and their selective impact on visual orientation discrimination (Leo, Romei, Freeman, Ladavas, & Driver, 2011) sugg...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2014.02.008

    authors: Cecere R,Romei V,Bertini C,Làdavas E

    更新日期:2014-04-01 00:00:00

  • To retrieve or to calculate? Left angular gyrus mediates the retrieval of arithmetic facts during problem solving.

    abstract::While there is consistent evidence from neuropsychological and brain imaging studies for an association between the left angular gyrus and mental arithmetic, its specific role in calculation has remained poorly understood. It has been speculated that the angular gyrus mediates the retrieval of arithmetic facts during ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2008.10.013

    authors: Grabner RH,Ansari D,Koschutnig K,Reishofer G,Ebner F,Neuper C

    更新日期:2009-01-01 00:00:00

  • Face context interferes with local part processing in a prosopagnosic patient.

    abstract::We investigated the role of local and global information on perceptual encoding of faces in patient HJA, who shows prosopagnosia and visual agnosia following occipito-temporal damage. HJA and an age-matched control were tested in a simultaneous matching task which focused on detection of local changes in faces: the in...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(02)00088-x

    authors: Boutsen L,Humphreys GW

    更新日期:2002-01-01 00:00:00

  • Why we may not find intentions in the brain.

    abstract::Intentions are commonly conceived of as discrete mental states that are the direct cause of actions. In the last several decades, neuroscientists have taken up the project of finding the neural implementation of intentions, and a number of areas have been posited as implementing these states. We argue, however, that t...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropsychologia.2014.01.010

    authors: Uithol S,Burnston DC,Haselager P

    更新日期:2014-04-01 00:00:00

  • Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype.

    abstract::The personality trait of novelty seeking (NS) has been associated with the long variant of the dopamine D4 receptor (L-DRD4) VNTR polymorphism. This is the first study to examine the influence of L-DRD4 polymorphism on some of the cognitive (i.e. decision making) and emotional underpinnings of the NS phenotype. One hu...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2009.02.005

    authors: Roussos P,Giakoumaki SG,Bitsios P

    更新日期:2009-06-01 00:00:00

  • Monitoring in language perception: evidence from ERPs in a picture-sentence matching task.

    abstract::P600 effects have been observed after syntactic ambiguous sentences, after several types of syntactic and semantic anomalies and after orthographic anomalies. On the basis of these findings, several investigators propose the P600 effect to reflect syntactic repair or syntactic restructuring. According to our Monitorin...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2007.11.027

    authors: Vissers CT,Kolk HH,van de Meerendonk N,Chwilla DJ

    更新日期:2008-03-07 00:00:00

  • Free recall in autism spectrum disorder: the role of relational and item-specific encoding.

    abstract::Autism spectrum disorders (ASDs) are characterised by a relatively specific pattern of typical and atypical memory functioning. Convergent behavioural and neuroscientific evidence indicates that this pattern of functioning may be the result of specific impairments in hippocampally mediated relational memory processes,...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2007.11.011

    authors: Gaigg SB,Gardiner JM,Bowler DM

    更新日期:2008-03-07 00:00:00

  • Study of unilateral hemisphere performance in children with developmental dysphasia.

    abstract::Hemisphere specialization for language was studied in 10 children with expressive developmental dysphasia (DD) (mean age 10 years 4 months) submitted to a dichotic listening task (in a word free-recall task and forced-attention task) and a finger tapping/vocalization dual-task paradigm. A nonsense shape dichaptic task...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(95)00020-4

    authors: Duvelleroy-Hommet C,Gillet P,Billard C,Loisel ML,Barthez MA,Santini JJ,Autret A

    更新日期:1995-07-01 00:00:00

  • EEG alpha synchronization is related to top-down processing in convergent and divergent thinking.

    abstract::Synchronization of EEG alpha activity has been referred to as being indicative of cortical idling, but according to more recent evidence it has also been associated with active internal processing and creative thinking. The main objective of this study was to investigate to what extent EEG alpha synchronization is rel...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2011.09.004

    authors: Benedek M,Bergner S,Könen T,Fink A,Neubauer AC

    更新日期:2011-10-01 00:00:00