The TALE face of Hox proteins in animal evolution.

abstract：:Organ size and architecture of plants are important traits affecting crop yield and agronomic practices. An induced mutant, multiple-organ gigantism (MOG), of black gram (Vigna mungo) has been obtained, which shows gigantic leaves, fruit, seed, and architecture (plant height) but lower number of pods per plant. These ...

journal_title：Frontiers in genetics

authors： Somta P,Chen J,Yimram T,Yundaeng C,Yuan X,Tomooka N,Chen X

更新日期：2020-06-30 00:00:00

abstract：:Evidence from clinical and epidemiological studies indicates that asthma is associated with allergic diseases including hay fever, allergic rhinitis, and eczema. Genetic analysis demonstrated that asthma had a positive genetic correlation with allergic diseases. A Mendelian randomization (MR) analysis using the rs1696...

journal_title：Frontiers in genetics

authors： Shen M,Liu X,Li G,Li Z,Zhou H

更新日期：2020-08-04 00:00:00

abstract：:As a conserved protein family, WRKY has been shown to be involved in multiple biological processes in plants. However, the mechanism of functional diversity for WRKYs in pepper has not been well elucidated. Here, a total of 223 WRKY members from solanaceae crops including pepper, tomato and potato, were analyzed using...

journal_title：Frontiers in genetics

authors： Cheng Y,Ahammed GJ,Yao Z,Ye Q,Ruan M,Wang R,Li Z,Zhou G,Wan H

更新日期：2019-05-28 00:00:00

abstract：:Neurodegenerative diseases share pathogenic mechanisms at the cellular level including protein misfolding, excitotoxicity and altered RNA homeostasis among others. Recent advances have shown that the genetic causes underlying these pathologies overlap, hinting at the existence of a genetic network for neurodegeneratio...

journal_title：Frontiers in genetics

authors： Therrien M,Parker JA

更新日期：2014-04-17 00:00:00

abstract：:Our understanding of the biological role of N6-methyladenosine (m6A), a ubiquitous non-editing RNA modification, has increased greatly since 2011. More recently, work from several labs revealed that m6A methylation regulates several aspects of mRNA metabolism. The "writer" protein METTL3, known as MT-A70 in humans, Dm...

journal_title：Frontiers in genetics

authors： Rockwell AL,Hongay CF

更新日期：2019-11-12 00:00:00

abstract：:Keratinocyte differentiation requires intricately coordinated spatiotemporal expression changes that specify epidermis structure and function. This article utilizes single-cell RNA-seq data from 22,338 human foreskin keratinocytes to reconstruct the transcriptional regulation of skin development and homeostasis genes,...

journal_title：Frontiers in genetics

authors： Finnegan A,Cho RJ,Luu A,Harirchian P,Lee J,Cheng JB,Song JS

更新日期：2019-09-03 00:00:00

abstract：:Functional annotation of the genome is important to understand the phenotypic complexity of various species. The road toward functional annotation involves several challenges ranging from experiments on individual molecules to large-scale analysis of high-throughput sequencing (HTS) data. HTS data is typically a resul...

journal_title：Frontiers in genetics

authors： Pundhir S,Poirazi P,Gorodkin J

更新日期：2015-05-19 00:00:00

abstract：PURPOSE:Genetic risk assessment is becoming an important component of clinical decision-making. Genetic Risk Scores (GRSs) allow the composite assessment of genetic risk in complex traits. A technically and clinically pertinent question is how to most easily and effectively combine a GRS with an assessment of clinical ...

journal_title：Frontiers in genetics

authors： Goldstein BA,Knowles JW,Salfati E,Ioannidis JP,Assimes TL

更新日期：2014-08-01 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fgene.2018.00657.]. ...

journal_title：Frontiers in genetics

authors： Cheng L,Zhuang H,Yang S,Jiang H,Wang S,Zhang J

更新日期：2019-02-18 00:00:00

abstract：:Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Transcriptomics studies often share similar hypotheses, but are carried out on different platforms, in different conditions, and with differ...

journal_title：Frontiers in genetics

authors： Wu C,Huang BE,Chen G,Lovenberg TW,Pocalyko DJ,Yao X

更新日期：2019-04-30 00:00:00

abstract：:For the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate the effectiveness of therapeutic interventions is still a major challe...

journal_title：Frontiers in genetics

authors： Mamoshina P,Volosnikova M,Ozerov IV,Putin E,Skibina E,Cortese F,Zhavoronkov A

更新日期：2018-07-12 00:00:00

abstract：:A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is the dominant risk factor for clinically significant atheroscleroti...

journal_title：Frontiers in genetics

authors： Head T,Daunert S,Goldschmidt-Clermont PJ

更新日期：2017-12-14 00:00:00

abstract：:Advances in technology have made it convenient to obtain a large amount of single cell RNA sequencing (scRNA-seq) data. Since that clustering is a very important step in identifying or defining cellular phenotypes, many clustering approaches have been developed recently for these applications. The general methods can ...

journal_title：Frontiers in genetics

authors： Zhu Y,Zhang DX,Zhang XF,Yi M,Ou-Yang L,Wu M

更新日期：2020-11-04 00:00:00

abstract：:It is time to review all the available data and find the distinctive characteristics of actin that make it such an important cell molecule. The presented double-stranded organization of filamentous actin cannot explain the strong polymorphism of actin fibrils. In this work, we performed bioinformatics analysis of a se...

journal_title：Frontiers in genetics

authors： Glyakina AV,Galzitskaya OV

更新日期：2020-12-10 00:00:00

abstract：:Some candidate genes have been robustly reported to be associated with complex traits, such as the fat mass and obesity-associated (FTO) gene on body mass index (BMI), and the fibroblast growth factor 5 (FGF5) gene on blood pressure levels. It is of interest to know whether an environmental factor (E) can attenuate or...

journal_title：Frontiers in genetics

authors： Lin WY,Lin YS,Chan CC,Liu YL,Tsai SJ,Kuo PH

更新日期：2020-05-08 00:00:00

abstract：:Proliferation and differentiation of preadipocyte are essential for the formation of fat tissues. However, the genes that regulate the early stage of preadipocyte differentiation in chicken have remained elusive. Here we identify a novel spliced variant of the DNA methyltransferase Dnmt3a gene, named Dnmt3a3, that con...

journal_title：Frontiers in genetics

authors： Abdalla BA,Li Z,Nie Q

更新日期：2020-02-25 00:00:00

abstract：:Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. MicroRNAs belong to epigenetic factors that regulate gene expression and have not ye...

journal_title：Frontiers in genetics

authors： Bogucka-Kocka A,Zalewski DP,Ruszel KP,Stępniewski A,Gałkowski D,Bogucki J,Komsta Ł,Kołodziej P,Zubilewicz T,Feldo M,Kocki J

更新日期：2019-11-22 00:00:00

abstract：:The Xichuan black-bone chicken, which is a rare local chicken species in China, is an important genetic resource of black-bone chickens. Tyrosine can affect melanin production, but the molecular mechanism underlying tyrosine-induced melanin deposition in Xichuan black-bone chickens is poorly understood. Here, the blac...

journal_title：Frontiers in genetics

authors： Li D,Wang X,Fu Y,Zhang C,Cao Y,Wang J,Zhang Y,Li Y,Chen Y,Li Z,Li W,Jiang R,Sun G,Tian Y,Li G,Kang X

更新日期：2019-05-15 00:00:00

abstract：:Retinoblastoma (Rb) is a primary intraocular malignant tumor that occurs primarily in children, and results from loss-of-function mutations in the RB transcriptional corepressor 1 (RB1) gene. Genetic testing forms the basis of genetic counseling for affected families, as well as for clinical management of this disease...

journal_title：Frontiers in genetics

authors： Lan X,Xu W,Tang X,Ye H,Song X,Lin L,Ren X,Yu G,Zhang H,Wu S

更新日期：2020-03-11 00:00:00

abstract：:The termites evolved eusociality and complex societies before the ants, but have been studied much less. The recent publication of the first two termite genomes provides a unique comparative opportunity, particularly because the sequenced termites represent opposite ends of the social complexity spectrum. Zootermopsis...

journal_title：Frontiers in genetics

authors： Korb J,Poulsen M,Hu H,Li C,Boomsma JJ,Zhang G,Liebig J

更新日期：2015-03-04 00:00:00

abstract：:The sustainable development of aquaculture has been impeded by infectious diseases worldwide. However, the genomic architecture and the genetic basis underlying the disease resistance remain poorly understood, which severely hampers both the understanding of the evolution of fish disease resistance traits and the prev...

journal_title：Frontiers in genetics

authors： Zhou Q,Su Z,Li Y,Liu Y,Wang L,Lu S,Wang S,Gan T,Liu F,Zhou X,Wei M,Liu G,Chen S

更新日期：2019-11-20 00:00:00

abstract：:Resistant Starch (RS), plays a crucial role in human health and nutrition by controlling glucose metabolism. RS or dietary fibre content in rice is low because it goes through a variety of process before it is ready for cooking and consumption. Hence, this study was carried out to develop a rice mutant with increased ...

journal_title：Frontiers in genetics

authors： Gurunathan S,Ramadoss BR,Mudili V,Siddaiah C,Kalagatur NK,Bapu JRK,Mohan CD,Alqarawi AA,Hashem A,Abd Allah EF

更新日期：2019-11-15 00:00:00

abstract：:The red junglefowl Gallus gallus is the main progenitor of domestic chicken, the commonest livestock species, outnumbering humans by an approximate ratio of six to one. The genetic control for production traits have been well studied in commercial chicken, but the selection pressures underlying unique adaptation and p...

journal_title：Frontiers in genetics

authors： Lawal RA,Al-Atiyat RM,Aljumaah RS,Silva P,Mwacharo JM,Hanotte O

更新日期：2018-07-20 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23), which is involved in the regulation of vitamin D, is an emerging independent risk factor for cardiovascular diseases. Previous studies have demonstrated a positive association between FGF23 and stroke. In this study, we aimed to assess the association of FGF23 with ischemic stroke ...

journal_title：Frontiers in genetics

authors： Zheng K,Lin L,Cui P,Liu T,Chen L,Yang C,Jiang W

更新日期：2020-12-23 00:00:00

abstract：:Binge drinking is a widespread problem linked to increased risk for alcohol-related complications, including development of alcohol use disorders. In the last decade, binge drinking has increased significantly, specifically in women. Clinically, sexually dimorphic effects of alcohol are well-characterized, however, th...

journal_title：Frontiers in genetics

authors： Rhinehart EM,Nentwig TB,Wilson DE,Leonard KT,Chaney BN,Grisel JE

更新日期：2018-11-29 00:00:00

abstract：:High-throughput genotyping boosts genome-wide association studies (GWAS) in crop species, leading to the identification of single-nucleotide polymorphisms (SNPs) associated with economically important traits. Choosing a cost-effective genotyping method for crop GWAS requires careful examination of several aspects, nam...

journal_title：Frontiers in genetics

authors： Pavan S,Delvento C,Ricciardi L,Lotti C,Ciani E,D'Agostino N

更新日期：2020-06-05 00:00:00

abstract：:Silversides are fish that inhabit marine coastal waters, coastal lagoons, and estuarine regions in southern South America. The freshwater (FW) silversides have the ability to tolerate salinity variations. Odontesthes humensis have similar habitats and biological characteristics of congeneric O. bonariensis, the most s...

journal_title：Frontiers in genetics

authors： Silveira TLR,Martins GB,Domingues WB,Remião MH,Barreto BF,Lessa IM,Santos L,Pinhal D,Dellagostin OA,Seixas FK,Collares T,Robaldo RB,Campos VF

更新日期：2018-02-06 00:00:00

abstract：:The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

journal_title：Frontiers in genetics

authors： Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

更新日期：2014-04-23 00:00:00

abstract：:Over millions of years, vertebrate species populated vast environments spanning the globe. Among the most challenging habitats encountered were those with limited availability of oxygen, yet many animal and human populations inhabit and perform life cycle functions and/or daily activities in varying degrees of hypoxia...

journal_title：Frontiers in genetics

authors： Pamenter ME,Hall JE,Tanabe Y,Simonson TS

更新日期：2020-07-22 00:00:00

abstract：:Improving grain yield in the staple food crop rice has been long sought goal of plant biotechnology. One of the traits with significant impact on rice breeding programs is peduncle elongation at the time of heading failing which leads to significant reduction in grain yield due to incomplete panicle exsertion. To deci...

journal_title：Frontiers in genetics

authors： Kandpal M,Vishwakarma C,Krishnan K,Chinnusamy V,Pareek A,Sharma MK,Sharma R

更新日期：2020-12-03 00:00:00